<SEC-DOCUMENT>0001104659-14-039975.txt : 20140519
<SEC-HEADER>0001104659-14-039975.hdr.sgml : 20140519
<ACCEPTANCE-DATETIME>20140519120713
ACCESSION NUMBER:		0001104659-14-039975
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20140519
DATE AS OF CHANGE:		20140519

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AASTROM BIOSCIENCES INC
		CENTRAL INDEX KEY:			0000887359
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				943096597
		STATE OF INCORPORATION:			MI
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-193861
		FILM NUMBER:		14853779

	BUSINESS ADDRESS:	
		STREET 1:		24 FRANKL LLOYD WRIGHT DR
		STREET 2:		PO BOX 376
		CITY:			ANN ARBOR
		STATE:			MI
		ZIP:			48106
		BUSINESS PHONE:		7349305555
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>a14-7456_11424b5.htm
<DESCRIPTION>424B5
<TEXT>


<html>
<head>

  </head>
<body lang="EN-US">
<div>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Filed pursuant to Rule&nbsp;424(b)(5)</font></b></p>
<p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:4.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Registration No.&nbsp;333-188186</font></b></p>
<p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:4.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">PROSPECTUS SUPPLEMENT NO. 6</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">TO THE PROSPECTUS DATED AUGUST 14, 2013</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">AS SUPPLEMENTED BY PROSPECTUS SUPPLEMENT NOS. 1, 2, 3, 4 AND 5</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">DATED MARCH&nbsp;21, APRIL 24, MAY&nbsp;5, MAY&nbsp;12, 2014, AND MAY&nbsp;16, 2014</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Aastrom Bioscience,&nbsp;Inc.</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">This Prospectus Supplement No.&nbsp;6 updates, amends and supplements our Prospectus dated August&nbsp;14, 2013, as amended and supplemented by Prospectus Supplement No.&nbsp;1 dated March&nbsp;21, 2014,&#160; Prospectus Supplement No.2 dated April&nbsp;24, 2014, Prospectus Supplement No.&nbsp;3 dated May&nbsp;5, 2014, Prospectus Supplement No.&nbsp;4 dated May&nbsp;12, 2014 and Prospectus Supplement No.&nbsp;5 dated May&nbsp;16, 2014 (collectively, the &#147;Prospectus&#148;), which forms a part of our Registration Statement on Form&nbsp;S-1 (Registration No.&nbsp;333-188186).</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">We incorporated by reference into this Prospectus Supplement No.&nbsp;6 the Quarterly Report on Form&nbsp;10-Q of Aastrom Biosciences,&nbsp;Inc. for quarter ended March&nbsp;31, 2014, filed with the Securities and Exchange Commission on May&nbsp;15, 2014.</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">This Prospectus Supplement No.&nbsp;6 should be read in conjunction with the Prospectus. To the extent information in this Prospectus Supplement No.&nbsp;6 differs from, updates or conflicts with information contained in the Prospectus, the information in this Prospectus Supplement No.&nbsp;6 is the more current information.</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">Investing in our common stock involves a high degree of risk. You should review carefully the &#147;Risk Factors&#148; beginning on page&nbsp;10 of the Prospectus dated August&nbsp;14, 2013 for a discussion of certain risks that you should consider.</font></b></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus supplement. Any representation to the contrary is a criminal offense.</font></b></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The date of this prospectus supplement is May&nbsp;19, 2014.</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
</div>
<!-- SEQ.=1,FOLIO='',FILE='C:\JMS\C901808\14-7456-11\task6792616\7456-11-bc.htm',USER='C901808',CD='May 19 21:13 2014' -->

<br clear="all" style="page-break-before:always;">
<div style="font-family:Times New Roman;">
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">INCORPORATION BY REFERENCE</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:13.7pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">This prospectus incorporates by reference important business and financial information that we file with the SEC and that we are not including in or delivering with this prospectus.&nbsp; As the SEC allows, incorporated documents are considered part of this prospectus, and we can disclose important information to you by referring you to those documents.&nbsp; We incorporate by reference the documents listed below:</font></p>
<p style="margin:0in 0in .0001pt;text-indent:13.7pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt .5in;text-indent:-.25in;"><font size="2" face="Symbol" style="font-size:10.0pt;">&#183;</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">our current report on Form&nbsp;10-Q, filed with the SEC on May&nbsp;15, 2014, (excluding any information furnished in such reports under Item 2.02,&nbsp;Item 7.01 or Item 9.01);</font></p>
<p style="margin:0in 0in .0001pt .5in;text-indent:-.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt .5in;text-indent:-.25in;"><font size="2" face="Symbol" style="font-size:10.0pt;">&#183;</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">the description of the rights to purchase shares of our Series&nbsp;A Junior Participating Cumulative Preferred Stock contained in the Registration Statement on Form&nbsp;8-A, filed with the SEC on August&nbsp;12, 2011, including any amendment or report for the purpose of updating such description; and</font></p>
<p style="margin:0in 0in .0001pt .5in;text-indent:-.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt .5in;text-indent:-.25in;"><font size="2" face="Symbol" style="font-size:10.0pt;">&#183;</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">the description of our common stock contained in our registration statements on Form&nbsp;S-1, filed with the SEC on November&nbsp;1, 1996, filed with the SEC on&#160; including any amendment or report filed for the purpose of updating such description.</font></p>
<p style="margin:0in 0in .0001pt .5in;text-indent:-.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:13.7pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to Rule&nbsp;412 under the Securities Act, any statement contained in a document incorporated or deemed to be incorporated by reference into this prospectus will be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained in this prospectus or any other subsequently filed document that is deemed to be incorporated by reference into this prospectus modifies or supersedes the statement. Any statement so modified or superseded will not be deemed, except as so modified or superseded, to constitute a part of this prospectus.</font></p>
<p style="margin:0in 0in .0001pt;text-indent:13.7pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:13.7pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">You may request a copy of any or all of these filings, at no cost, by writing to us at: Aastrom Biosciences,&nbsp;Inc., 24 Frank Lloyd Wright Drive, Lobby K, Ann Arbor, Michigan 48105, Attention: Investor Relations, or by telephoning us at (734)&nbsp;418-4400.&nbsp; These filings may also be obtained through our website located at http://www.aastrom.com.&nbsp; The reference to our website is intended to be an inactive textual reference and, except for the documents incorporated by reference as noted above, the information on, or accessible through, our website is not intended to be part of this prospectus.</font></p>
<p style="margin:0in 0in .0001pt;text-indent:13.7pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:13.7pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">You should rely only on the information incorporated by reference or provided in this prospectus or any supplement.&nbsp; We have not authorized anyone else to provide you with different information.&nbsp; You should not assume that information in this prospectus or any supplement is accurate as of any date other than the date on the front of these documents.</font></p>
<p style="margin:0in 0in .0001pt;text-indent:13.7pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:13.7pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">We advise that there have been no material changes in our affairs that have occurred since the end of the latest fiscal period for which audited financial statements were included in the latest Form&nbsp;10-K and that have not been described in a Form&nbsp;8-K filed under the Exchange Act.</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
</div>
<!-- SEQ.=1,FOLIO='',FILE='C:\JMS\C901808\14-7456-11\task6792616\7456-11-bc.htm',USER='C901808',CD='May 19 21:13 2014' -->

</body>
</html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
