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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0000898432-08-000055.txt : 20080130
<SEC-HEADER>0000898432-08-000055.hdr.sgml : 20080130
<ACCEPTANCE-DATETIME>20080129175756
ACCESSION NUMBER:		0000898432-08-000055
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20080130
DATE AS OF CHANGE:		20080129
GROUP MEMBERS:		BIOTECHNOLOGY VALUE FUND II, L.P.
GROUP MEMBERS:		BVF INC.
GROUP MEMBERS:		BVF INVESTMENTS, L.L.C.
GROUP MEMBERS:		BVF PARTNERS L.P.
GROUP MEMBERS:		INVESTMENT 10, L.L.C.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AVANT IMMUNOTHERAPEUTICS INC
		CENTRAL INDEX KEY:			0000744218
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				133191702
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-37761
		FILM NUMBER:		08559170

	BUSINESS ADDRESS:	
		STREET 1:		119 FOURTH AVE
		CITY:			NEEDHAM
		STATE:			MA
		ZIP:			02494
		BUSINESS PHONE:		7814330771

	MAIL ADDRESS:	
		STREET 1:		119 FOURTH AVE
		CITY:			NEEDHAM
		STATE:			MA
		ZIP:			021942725

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	T CELL SCIENCES INC
		DATE OF NAME CHANGE:	19920703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOTECHNOLOGY VALUE FUND L P
		CENTRAL INDEX KEY:			0000918923
		STANDARD INDUSTRIAL CLASSIFICATION:	INVESTMENT ADVICE [6282]
		IRS NUMBER:				363924731
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		900 N. MICHIGAN AVENUE, SUITE 1100
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60611
		BUSINESS PHONE:		3125066500

	MAIL ADDRESS:	
		STREET 1:		900 N. MICHIGAN AVENUE, SUITE 1100
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60611
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>sc13g.htm
<TEXT>
<HTML>
<HEAD>
<TITLE></TITLE>
</HEAD>
<BODY style="line-height:12pt; font-family:Times New Roman; font-size:10pt; color:#000000">
<DIV style="width:624px"><P style="margin:0px; padding:4px; border-top:1px solid #000000; border-bottom:1px solid #000000"><BR></P>
<P style="line-height:normal; margin-top:6.667px; margin-bottom:6.667px; font-size:16px" align=center><B>SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, DC 20549 </B></P>
<P style="line-height:normal; margin-top:6.667px; margin-bottom:6.667px; font-size:18px" align=center><B>SCHEDULE 13G<BR>
(Rule&nbsp;13d-102) </B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px" align=center><B>INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT<BR>
TO RULES 13d-1(b) (c)&nbsp;AND (d)&nbsp;AND AMENDMENTS THERETO FILED<BR>
PURSUANT TO 13d-2(b)<BR>
</B></P>
<TABLE style="font-size:13.333px" cellspacing=0 align=center><TR><TD width=393.133></TD></TR>
<TR><TD valign=top width=393.133><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>Avant Immunotherapeutics, Inc.</B></P>
<P style="margin:0px" align=center>(Name of Issuer)</P>
</TD></TR>
<TR><TD valign=top width=393.133><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=393.133><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>Common Stock</B></P>
<P style="margin:0px" align=center>(Title of Class of Securities)</P>
</TD></TR>
<TR><TD valign=top width=393.133><P style="margin:0px"><BR>
&nbsp;</P>
</TD><A NAME="OLE_LINK1"></A><A NAME="OLE_LINK2"></A></TR>
<TR><TD valign=top width=393.133><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>053491106</B></P>
<P style="margin:0px" align=center>(CUSIP Number)</P>
</TD></TR>
<TR><TD valign=top width=393.133><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=393.133><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>December 31, 2007</B></P>
<P style="margin:0px" align=center>(Date of Event Which Requires Filing of this Statement)</P>
</TD></TR>
</TABLE>
<P style="margin-top:6.667px; margin-bottom:6.667px">Check the appropriate box to designate the rule pursuant to which this Schedule is filed: </P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=19></TD><TD width=14.2></TD><TD width=441.067></TD></TR>
<TR><TD valign=top width=19><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=14.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=441.067><P style="margin:0px; font-family:Wingdings"><FONT FACE="Wingdings">o</FONT><FONT FACE="Times New Roman"> Rule&nbsp;13d-1(b)<BR>
</FONT>&#253;<FONT FACE="Times New Roman"> Rule&nbsp;13d-1(c)<BR>
</FONT>o<FONT FACE="Times New Roman"> Rule&nbsp;13d-1(d)</FONT></P>
</TD></TR>
</TABLE>
<P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000"><BR></P>
<P style="margin:5.533px"><BR></P>
<P style="margin-top:5.533px; margin-bottom:5.533px; text-indent:48px"><FONT FACE="Times New Roman">*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</FONT></P>
<P style="margin-top:6.667px; margin-bottom:6.667px; text-indent:48px">The information required on the remainder of this cover page shall not be deemed to be &quot;filed&quot; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, <I>see</I> the <I>Notes</I>). </P>
<P style="margin-top:0px; margin-bottom:16px"><BR>
<BR></P>
<P style="margin-top:0px; margin-bottom:16px; page-break-before:always"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>CUSIP No.&nbsp;053491106</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 2 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.267></TD><TD width=511.667></TD><TD width=18.733></TD><TD width=49.933></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>1</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>Biotechnology Value Fund, L.P.<BR>
</B> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.667><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=580.333 colspan=3><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=511.667><P style="margin:0px"><BR></P>
<P style="line-height:normal; margin:0px; font-size:16px">&nbsp;<B>Delaware</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=43.333></TD><TD width=6.267></TD><TD width=75></TD><TD width=18.733></TD><TD width=37.467></TD><TD width=6.267></TD><TD width=380.733></TD><TD width=18.733></TD><TD width=37.467></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.2 colspan=5><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>0</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR>
<FONT FACE="Times New Roman"><B>&nbsp;</B></FONT></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>11</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;<B>0%</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;TYPE OF REPORTING PERSON*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-bottom:2px solid #000000" valign=top width=43.333><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-bottom:2px solid #000000" valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD style="border-bottom:2px solid #000000" valign=top width=518.2 colspan=5><P style="line-height:normal; margin:0px; font-size:16px">&nbsp;<B>PN</B></P>
</TD><TD style="border-bottom:2px solid #000000" valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-bottom:2px solid #000000" valign=top width=37.467><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin-top:0px; margin-bottom:16px; page-break-before:always"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>CUSIP No.&nbsp;053491106</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 3 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.267></TD><TD width=511.667></TD><TD width=18.733></TD><TD width=49.933></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>1</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>Biotechnology Value Fund II, L.P.<BR>
</B> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.667><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-bottom:1px solid #000000" valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD style="border-bottom:1px solid #000000" valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD style="border-bottom:1px solid #000000" valign=top width=511.667><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>Delaware</B></P>
</TD><TD style="border-bottom:1px solid #000000" valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD style="border-bottom:1px solid #000000" valign=top width=49.933><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=43.333></TD><TD width=6.267></TD><TD width=75></TD><TD width=18.733></TD><TD width=37.467></TD><TD width=6.267></TD><TD width=380.733></TD><TD width=18.733></TD><TD width=37.467></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.2 colspan=5><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>0</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR>
<FONT FACE="Times New Roman"><B>&nbsp;</B></FONT></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>11</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.2 colspan=5><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>0%</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;TYPE OF REPORTING PERSON*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><B>PN</B></P>
</TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=37.467><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=43.333><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=518.2 colspan=5><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=37.467><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin-top:0px; margin-bottom:16px; page-break-before:always"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>CUSIP No.&nbsp;053491106</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 4 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.2></TD><TD width=80.867></TD><TD width=18.733></TD><TD width=37.467></TD><TD width=6.267></TD><TD width=368.267></TD><TD width=18.733></TD><TD width=50.067></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>1</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=5><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>BVF Investments, L.L.C.<BR>
 </B>I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=50.067><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=5><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=50.067><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=5><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=50.067><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=5><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=50.067><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=5><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=50.067><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.6 colspan=5><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=50.067><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=5><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=50.067><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-bottom:2px solid #000000" valign=top width=37.4><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD style="border-bottom:2px solid #000000" valign=top width=6.2><P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD style="border-bottom:2px solid #000000" valign=top width=511.6 colspan=5><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>Delaware</B></P>
</TD><TD style="border-bottom:2px solid #000000" valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-bottom:2px solid #000000" valign=top width=50.067><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.8 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.8 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.8 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=43.6></TD><TD width=6.267></TD><TD width=517.933></TD><TD width=18.733></TD><TD width=37.467></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=517.933><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.6><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=517.933><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>0</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=517.933><P style="margin:0px">&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.6><P style="margin:0px" align=center><BR>
<FONT FACE="Times New Roman"><B>&nbsp;</B></FONT></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=517.933><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6><P style="margin:0px" align=center><B>11</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=517.933><P style="margin:0px">&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.6><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=517.933><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;<B>0%</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=517.933><P style="margin:0px">&nbsp;TYPE OF REPORTING PERSON*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.6><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=517.933><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>OO</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin-top:0px; margin-bottom:16px; page-break-before:always"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>CUSIP No.&nbsp;053491106</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 5 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.267></TD><TD width=511.667></TD><TD width=18.733></TD><TD width=49.933></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>1</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>Investment 10, L.L.C.<BR>
 </B>I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.667><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.667><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>Illinois</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=43.467></TD><TD width=6.267></TD><TD width=74.867></TD><TD width=18.733></TD><TD width=37.467></TD><TD width=6.267></TD><TD width=380.733></TD><TD width=18.733></TD><TD width=37.467></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>0</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><BR>
<FONT FACE="Times New Roman"><B>&nbsp;</B></FONT></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>11</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>0%</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;TYPE OF REPORTING PERSON*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>OO</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin-top:0px; margin-bottom:16px; page-break-before:always"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>CUSIP No.&nbsp;053491106</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 6 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.267></TD><TD width=511.667></TD><TD width=18.733></TD><TD width=49.933></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>1</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>BVF Partners L.P.<BR>
</B> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.667><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.667><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>Delaware</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=43.467></TD><TD width=6.267></TD><TD width=74.867></TD><TD width=18.733></TD><TD width=37.467></TD><TD width=6.267></TD><TD width=380.733></TD><TD width=18.733></TD><TD width=37.467></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>0</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><BR>
<FONT FACE="Times New Roman"><B>&nbsp;</B></FONT></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>11</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>0%</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;TYPE OF REPORTING PERSON*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>PN</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin-top:0px; margin-bottom:16px; page-break-before:always"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>CUSIP No.&nbsp;053491106</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 7 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.2></TD><TD width=6.2></TD><TD width=74.4></TD><TD width=18.733></TD><TD width=37.467></TD><TD width=6.267></TD><TD width=368.667></TD><TD width=12.733></TD><TD width=6></TD><TD width=12.733></TD><TD width=37.2></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>1</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=6><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>BVF Inc.<BR>
</B> S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=12><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=6><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=12><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=6><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.733 colspan=6><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=12><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=6><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.733 colspan=6><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>Delaware</B></P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=12><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.333 colspan=5><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.333 colspan=5><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=481.067 colspan=7><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.333 colspan=5><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.333 colspan=5><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=481.067 colspan=7><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.333 colspan=5><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.333 colspan=5><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=481.067 colspan=7><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.333 colspan=5><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.2 colspan=4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.333 colspan=5><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=12><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.267 colspan=6><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.267 colspan=6><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>0</B></P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.2><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=12><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.267 colspan=6><P style="margin:0px">&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.2><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><BR>
<FONT FACE="Times New Roman"><B>&nbsp;</B></FONT></P>
</TD><TD valign=top width=6.2><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.267 colspan=6><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.2><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=12><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><B>11</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.267 colspan=6><P style="margin:0px">&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.267 colspan=6><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>0%</B></P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.2><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=12><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.267 colspan=6><P style="margin:0px">&nbsp;TYPE OF REPORTING PERSON*</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=518.267 colspan=6><P style="line-height:normal; margin:0px; font-size:16px"><BR>
&nbsp;<B>IA, CO</B></P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=37.2><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=12><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin-top:0px; margin-bottom:16px; page-break-before:always"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>CUSIP No.&nbsp;053491106</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 8 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 1(a).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NAME OF ISSUER:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Avant Immunotherapeutics, Inc. (&#147;Avant&#148;)</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 1(b).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:</B></P>
<P style="margin:0px; text-indent:96px">119 Fourth Avenue</P>
<P style="margin:0px; text-indent:96px">Needham, MA 02494-2725</P>
<P style="margin:0px"><BR></P>
<P style="margin:0px"><B>ITEM 2(a).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NAME OF PERSON FILING:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Schedule 13G is being filed on behalf of the following persons (the &quot;Reporting Persons&quot;):</P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=87.333></TD><TD width=31.2></TD><TD width=18.733></TD><TD width=486.733></TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(i)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;Biotechnology Value Fund, L.P. (&quot;BVF&quot;)</P>
</TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(ii)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;Biotechnology Value Fund II, L.P. (&quot;BVF2&quot;)</P>
</TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(iii)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;BVF Investments, L.L.C. (&quot;Investments&quot;)</P>
</TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(iv)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;Investment 10, L.L.C. (&quot;ILL10&quot;)</P>
</TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(v)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;BVF Partners L.P. (&quot;Partners&quot;)</P>
</TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(vi)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;BVF&nbsp;Inc. (&quot;BVF&nbsp;Inc.&quot;)</P>
</TD></TR>
</TABLE>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 2(b).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ADDRESS OF PRINCIPAL BUSINESS OFFICE:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The principal business office of the Reporting Persons comprising the group filing this Schedule&nbsp;13G is located at 900 North Michigan Avenue, Suite 1100, Chicago, Illinois, 60611.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 2(c).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CITIZENSHIP:</B></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=68.6></TD><TD width=18.733></TD><TD width=112.333></TD><TD width=424.333></TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;BVF:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;a Delaware limited partnership</P>
</TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;BVF2:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;a Delaware limited partnership</P>
</TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;Investments:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;a Delaware limited liability company</P>
</TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;ILL10:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;an Illinois limited liability company</P>
</TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;Partners:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;a Delaware limited partnership</P>
</TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;BVF&nbsp;Inc.:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;a Delaware corporation</P>
</TD></TR>
</TABLE>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 2(d).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;TITLE OF CLASS OF SECURITIES:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Schedule 13G is being filed with respect to the common stock, par value $0.001 per share (&quot;Common Stock&quot;), of Avant. &nbsp;The Reporting Persons' percentage ownership of Common Stock is based on 74,188,066 shares of Common Stock being outstanding. </P>
<P style="margin-top:5.533px; margin-bottom:-16px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
<P style="margin-top:0px; margin-bottom:6.667px; text-indent:72px">&nbsp;&nbsp;&nbsp;&nbsp;As of December 31, 2007, BVF, BVF2, Investments, ILL10, Partners and BVF do not beneficially own any shares of Common Stock of Avant.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 2(e).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CUSIP Number:</B></P>
<P style="line-height:normal; margin:0px; padding-bottom:4px; font-size:16px; border-bottom:2px solid #000000">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>053491106</B></P>
<P style="margin:6.667px"><BR>
<BR></P>
<P style="margin-top:0px; margin-bottom:16px; page-break-before:always"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>CUSIP No.&nbsp;053491106</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 9 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), or 13d-2(b) or (c)&nbsp;CHECK WHETHER THE PERSON FILING IS: &nbsp;&nbsp;&nbsp;One of the following</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable as this Schedule&nbsp;13G is filed pursuant to Rule&nbsp;13d-1(c).</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;OWNERSHIP:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The information in items 1 and 5 through 11 on the cover pages (pp. 2&nbsp;-&nbsp;7) on this Schedule&nbsp;13G is hereby incorporated by reference.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If this statement is being filed to report the fact that as of the date hereof the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities check the following.&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:</B></P>
<P style="margin-top:5.533px; margin-bottom:5.533px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF A GROUP:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NOTICE OF DISSOLUTION OF GROUP:</B></P>
<P style="margin-top:5.533px; margin-bottom:5.533px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</P>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin-top:0px; margin-bottom:16px; page-break-before:always"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>CUSIP No.&nbsp;053491106</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 10 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CERTIFICATION</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. </P>
<P style="margin-top:5.533px; margin-bottom:5.533px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. </P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=74></TD><TD width=7></TD><TD width=543></TD></TR>
<TR><TD valign=top width=74><P style="margin:0px">Dated:</P>
</TD><TD valign=top width=7><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=543><P style="margin:0px">January 29, 2008</P>
</TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=35.733></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=193.133></TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=260.933 colspan=7><P style="margin:0px"><BR>
<B>BIOTECHNOLOGY VALUE FUND, L.P.</B></P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=238.333 colspan=5><P style="margin:0px"><BR>
BVF Partners L.P., its general partner</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=215.733 colspan=3><P style="margin:0px"><BR>
BVF Inc., its general partner</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=193.133><P style="margin:0px"><BR>
&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=193.133><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 President</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=260.933 colspan=7><P style="margin:0px"><BR>
<B>BIOTECHNOLOGY VALUE FUND II, L.P.</B></P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=238.333 colspan=5><P style="margin:0px"><BR>
BVF Partners L.P., its general partner</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=215.733 colspan=3><P style="margin:0px"><BR>
BVF Inc., its general partner</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=193.133><P style="margin:0px"><BR>
&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=193.133><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 President</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=260.933 colspan=7><P style="margin:0px"><BR>
<B>BVF INVESTMENTS, L.L.C.</B></P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=238.333 colspan=5><P style="margin:0px"><BR>
BVF Partners L.P., its manager</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=215.733 colspan=3><P style="margin:0px"><BR>
BVF Inc., its general partner</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=193.133><P style="margin:0px"><BR>
&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=193.133><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 &nbsp;President</P>
</TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=6.8></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=222.067></TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=289.867 colspan=7><P style="margin:0px"><BR>
<B>INVESTMENT 10, L.L.C.</B></P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=267.267 colspan=5><P style="margin:0px"><BR>
BVF Partners L.P., its attorney-in-fact</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=244.667 colspan=3><P style="margin:0px"><BR>
BVF Inc., its general partner</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=222.067><P style="margin:0px"><BR>
&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=222.067><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 President</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=289.867 colspan=7><P style="margin:0px"><BR>
<B>BVF PARTNERS L.P.</B></P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=267.267 colspan=5><P style="margin:0px"><BR>
BVF Inc., its general partner</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=222.067><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=222.067><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 President</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=289.867 colspan=7><P style="margin:0px"><BR></P>
<P style="margin:0px"><BR>
<B>BVF INC.</B></P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=222.067><P style="margin:0px"><BR>
&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=222.067><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 President</P>
</TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<P style="margin:0px"><BR></P>
<P style="margin:0px"><BR>
<BR></P>
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