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STOCK-BASED COMPENSATION (Tables) | 12 Months Ended
--- | ---
Dec. 31, 2012
STOCK-BASED COMPENSATION |
Summary of stock option activity |
|  | Shares |  | Weighted Average Exercise Price Per Share |  | Weighted Average Remaining Contractual Term (In Years) |
--- | --- | --- | --- | --- | --- | --- | ---
Options Outstanding at December 31, 2011 |  |  | 4,459,034 |  | $ | 6.08 |  |  | 6.9 |
Granted |  |  | 1,144,484 |  | $ | 5.83 |  |  |  |
Exercised |  |  | (52,652 | ) | $ | 2.83 |  |  |  |
Canceled |  |  | (201,056 | ) | $ | 8.22 |  |  |  |
Options Outstanding at December 31, 2012 |  |  | 5,349,810 |  | $ | 5.98 |  |  | 7.0 |
Options Vested and Expected to Vest at December 31, 2012 |  |  | 5,279,983 |  | $ | 5.99 |  |  | 6.9 |
Options Exercisable at December 31, 2012 |  |  | 3,306,468 |  | $ | 6.71 |  |  | 5.7 |
Shares Available for Grant under the 2008 Plan |  |  | 3,352,081 |  |  |  |  |  |  |
Summary of restricted stock activity |
|  | Shares |  | Weighted Average Grant Date Fair Value (per share) |
--- | --- | --- | --- | --- | ---
Outstanding and unvested at December 31, 2011 |  |  | 6,000 |  | $ | 3.24 |
Granted |  |  | 12,000 |  | $ | 4.50 |
Vested |  |  | (12,000 | ) | $ | 3.87 |
Canceled |  |  | — |  |  | — |
Outstanding and unvested at December 31, 2012 |  |  | 6,000 |  | $ | 4.50 |
Schedule of stock-based compensation expense |
|  | 2012 |  | 2011 |  | 2010 |
--- | --- | --- | --- | --- | --- | --- | ---
|  | (In thousands) |
Research and development |  | $ | 1,415 |  | $ | 1,412 |  | $ | 1,625 |
General and administrative |  |  | 883 |  |  | 930 |  |  | 1,177 |
Total stock-based compensation expense |  | $ | 2,298 |  | $ | 2,342 |  | $ | 2,802 |
Schedule of assumptions used for the fair values of employee stock options granted |
|  | Year Ended December 31, 2012 |  | Year Ended December 31, 2011 |  | Year Ended December 31, 2010
--- | --- | --- | --- | --- | --- | ---
Expected stock price volatility |  | 70 - 72% |  | 68 - 70% |  | 65 - 67%
Expected option term |  | 6.0 Years |  | 6.0 Years |  | 6.2 Years
Risk-free interest rate |  | 0.9 - 1.4% |  | 1.4 - 2.9% |  | 1.8 - 3.2%
Expected dividend yield |  | None |  | None |  | None

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph g(1) -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph 64 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=6793087&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure of the changes in outstanding nonvested shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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