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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $) In Thousands, except Per Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
REVENUE: |  |  |
Product Development and Licensing Agreements | $ 146 | $ 110 | $ 40,187
Contracts and Grants | 281 | 36 | 220
Product Royalties | 10,775 | 9,119 | 6,386
Total Revenue | 11,202 | 9,265 | 46,793
OPERATING EXPENSE: |  |  |
Research and Development | 47,398 | 32,439 | 27,650
Royalty | 10,775 | 9,119 | 12,077
General and Administrative | 10,016 | 9,193 | 10,378
Amortization of Acquired Intangible Assets | 1,090 | 1,913 | 3,143
Total Operating Expense | 69,279 | 52,664 | 53,248
Operating Loss | (58,077) | (43,399) | (6,455)
Investment and Other Income, Net | 530 | 396 | 5,259
Interest Expense | (1,576) | (1,796) | (1,337)
Net Loss | (59,123) | (44,799) | (2,533)
Basic and Diluted Net Loss Per Common Share (See Note 2) (in dollars per share) | $ (1.02) | $ (1.13) | $ (0.08)
Shares Used in Calculating Basic and Diluted Net Loss per Share (See Note 2) (in shares) | 57,713 | 39,501 | 31,868
COMPREHENSIVE LOSS: |  |  |
Net Loss | (59,123) | (44,799) | (2,533)
Other Comprehensive Income (Loss): |  |  |
Foreign Currency Translation Adjustments | 2 | (9) | 2
Unrealized Gain (Loss) on Marketable Securities | 91 | (90) | 203
Comprehensive Loss | $ (59,030) | $ (44,898) | $ (2,328)

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