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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $) In Thousands, except Per Share data, unless otherwise specified | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2013 | Sep. 30, 2012 | Sep. 30, 2013 | Sep. 30, 2012
REVENUE: |  |  |  |
Product Development and Licensing Agreements | $ 40 | $ 28 | $ 117 | $ 103
Contracts and Grants | 940 | 79 | 1,040 | 228
Product Royalties |  | 3,006 | 2,334 | 7,224
Total Revenue | 980 | 3,113 | 3,491 | 7,555
OPERATING EXPENSE: |  |  |  |
Research and Development | 20,417 | 11,769 | 49,597 | 33,650
Royalty |  | 3,006 | 2,334 | 7,224
General and Administrative | 3,578 | 2,835 | 10,128 | 7,372
Amortization of Acquired Intangible Assets | 254 | 254 | 760 | 836
Total Operating Expense | 24,249 | 17,864 | 62,819 | 49,082
Operating Loss | (23,269) | (14,751) | (59,328) | (41,527)
Investment and Other Income, Net | 142 | 105 | 682 | 436
Interest Expense | (13) | (381) | (842) | (1,225)
Net Loss | (23,140) | (15,027) | (59,488) | (42,316)
Basic and Diluted Net Loss Per Common Share (Note 3) (in dollars per share) | $ (0.29) | $ (0.25) | $ (0.76) | $ (0.75)
Shares Used in Calculating Basic and Diluted Net Loss per Share (Note 3) (in shares) | 81,015 | 59,467 | 78,676 | 56,090
COMPREHENSIVE LOSS: |  |  |  |
Net Loss | (23,140) | (15,027) | (59,488) | (42,316)
Other Comprehensive (Loss) Income: |  |  |  |
Foreign Currency Translation Adjustments |  | 1 | (3) | 2
Unrealized Gain (Loss) on Marketable Securities | 138 | 52 | (56) | 121
Comprehensive Loss | $ (23,002) | $ (14,974) | $ (59,547) | $ (42,193)

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- Definition The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6388964&loc=d3e16225-109274 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=26713463&loc=d3e16323-109275 + Details
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- Definition Total costs of sales and operating expenses for the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03) -URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688 + Details
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