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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (USD $) In Thousands, except Share data, unless otherwise specified | Total | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income | Accumulated Deficit
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2010 | $ 75,255 | $ 32 | $ 232,679 | $ 2,751 | $ (160,207)
Balance (in shares) at Dec. 31, 2010 |  | 32,055,382 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans | 173 |  | 173 |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) |  | 80,254 |  |  |
Shares Issued in Connection with Cantor Agreement | 2,155 | 1 | 2,154 |  |
Shares Issued in Connection with Cantor Agreement (in shares) |  | 575,000 |  |  |
Shares Issued in Underwritten Offering | 33,695 | 11 | 33,684 |  |
Shares Issued in Underwritten Offering (in shares) | 11,500,000 | 11,500,000 |  |  |
Share-Based Compensation | 2,342 |  | 2,342 |  |
Foreign Currency Translation Adjustments | (9) |  |  | (9) |
Unrealized Gains (Losses) on Marketable Securities | (90) |  |  | (90) |
Net Loss | (44,799) |  |  |  | (44,799)
Balance at Dec. 31, 2011 | 68,722 | 44 | 271,032 | 2,652 | (205,006)
Balance (in shares) at Dec. 31, 2011 |  | 44,210,636 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans | 163 |  | 163 |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) |  | 70,587 |  |  |
Shares Issued in Connection with Cantor Agreement | 40,138 | 8 | 40,130 |  |
Shares Issued in Connection with Cantor Agreement (in shares) |  | 8,003,290 |  |  |
Shares Issued in Underwritten Offering | 43,483 | 12 | 43,471 |  |
Shares Issued in Underwritten Offering (in shares) | 12,075,000 | 12,075,000 |  |  |
Share-Based Compensation | 2,298 |  | 2,298 |  |
Foreign Currency Translation Adjustments | 2 |  |  | 2 |
Unrealized Gains (Losses) on Marketable Securities | 91 |  |  | 91 |
Net Loss | (59,123) |  |  |  | (59,123)
Balance at Dec. 31, 2012 | 95,774 | 64 | 357,094 | 2,745 | (264,129)
Balance (in shares) at Dec. 31, 2012 | 64,359,513 | 64,359,513 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans | 5,403 | 1 | 5,402 |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) |  | 840,228 |  |  |
Shares Issued in Connection with Cantor Agreement | 17,134 | 2 | 17,132 |  |
Shares Issued in Connection with Cantor Agreement (in shares) |  | 2,433,608 |  |  |
Shares Issued in Underwritten Offering | 278,563 | 22 | 278,541 |  |
Shares Issued in Underwritten Offering (in shares) | 21,613,483 | 21,613,483 |  |  |
Share-Based Compensation | 4,548 |  | 4,548 |  |
Foreign Currency Translation Adjustments | (3) |  |  | (3) |
Unrealized Gains (Losses) on Marketable Securities | (74) |  |  | (74) |
Net Loss | (81,550) |  |  |  | (81,550)
Balance at Dec. 31, 2013 | $ 319,795 | $ 89 | $ 662,717 | $ 2,668 | $ (345,679)
Balance (in shares) at Dec. 31, 2013 | 89,246,832 | 89,246,832 |  |  |

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