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Income Taxes - Deferred Tax (Details) - USD ($) $ in Thousands | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 22, 2017 | Dec. 31, 2016
Gross Deferred Tax Assets |  |  |  |
Net Operating Loss Carryforwards |  | $ 146,228 |  | $ 174,555
Foreign Net Operating Loss Carryforwards |  | 3,572 |  | 1,124
Tax Credit Carryforwards |  | 36,458 |  | 32,306
Deferred Research and Development Expenses |  | 79,272 |  | 109,520
Stock-based Compensation |  | 10,718 |  | 12,362
Fixed Assets |  | 1,305 |  | 1,526
Deferred Revenue |  | 686 |  | 1,418
Accrued Expenses and Other |  | 316 |  | 894
Gross Deferred Tax Assets |  | 278,555 |  | 333,705
Gross Deferred Tax Liabilities |  |  |  |
Other Acquired Intangibles |  | (1,792) |  | (2,868)
IPR&D Intangibles |  | (15,992) |  | (28,054)
Total Deferred Tax Assets and Liabilities |  | 260,771 |  | 302,783
Valuation Allowance |  | (264,543) |  | (330,837)
Net Deferred Tax Liability |  | (3,772) |  | $ (28,054)
Principal components of the deferred tax assets and liabilities |  |  |  |
Increase in deferred tax and valuation allowance |  | $ 17,700 |  |
U.S. federal corporate income tax rate (as a percent) |  | 35.00% |  |
Change in tax rate, deferred tax liability benefit |  | $ 6,900 |  |
Additional income tax benefit leading to tax liabilities |  | 12,200 |  |
Revaluation of deferred tax asset |  | 99,500 |  |
Income tax benefit |  | $ 5,200 |  |
Forecast |  |  |  |
Principal components of the deferred tax assets and liabilities |  |  |  |
U.S. federal corporate income tax rate (as a percent) | 21.00% |  |  |
Maximum |  |  |  |
Principal components of the deferred tax assets and liabilities |  |  |  |
U.S. federal corporate income tax net operating losses (as a percent) |  |  | 80.00% |

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