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STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income | Accumulated Deficit | Total
--- | --- | --- | --- | --- | ---
Period Start Balance at Dec. 31, 2014 | $ 90 | $ 672,739 | $ 2,590 | $ (463,759) | $ 211,660
Balance (in shares) at Dec. 31, 2014 | 89,592,779 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans | $ 1 | 4,310 |  |  | 4,311
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) | 755,316 |  |  |  |
Shares Issued in Underwritten Offering | $ 8 | 188,832 |  |  | 188,840
Shares Issued in Underwritten Offering (in shares) | 8,337,500 |  |  |  |
Share-Based Compensation |  | 12,774 |  |  | 12,774
Foreign Currency Translation Adjustments |  |  | 15 |  | 15
Unrealized Gains (Losses) on Marketable Securities |  |  | (298) |  | (298)
Net Loss |  |  |  | (127,197) | (127,197)
Period End Balance at Dec. 31, 2015 | $ 99 | 878,655 | 2,307 | (590,956) | 290,105
Balance (in shares) at Dec. 31, 2015 | 98,685,595 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans | $ 1 | 534 |  |  | 535
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) | 158,152 |  |  |  |
Shares Issued in Connection with Cantor Agreement | $ 3 | 13,943 |  |  | 13,946
Shares Issued in Connection with Cantor Agreement (in shares) | 3,303,800 |  |  |  |
Shares Issued in Connection with the Kolltan Acquisition | $ 18 | 73,379 |  |  | 73,397
Shares Issued in Connection with the Kolltan Acquisition (in shares) | 18,257,996 |  |  |  |
Shares Issued in Connection with Kolltan Severance |  | 427 |  |  | 427
Shares Issued in Connection with Kolltan Severance (in shares) | 111,111 |  |  |  |
Share-Based Compensation |  | 15,317 |  |  | 15,317
Unrealized Gains (Losses) on Marketable Securities |  |  | 234 |  | 234
Net Loss |  |  |  | (128,530) | (128,530)
Period End Balance at Dec. 31, 2016 | $ 121 | 982,255 | 2,541 | (719,486) | $ 265,431
Balance (in shares) at Dec. 31, 2016 | 120,516,654 |  |  |  | 120,516,654
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans |  | 265 |  |  | $ 265
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) | 173,712 |  |  |  |
Shares Issued in Connection with Cantor Agreement | $ 18 | 51,007 |  |  | 51,025
Shares Issued in Connection with Cantor Agreement (in shares) | 17,722,863 |  |  |  |
Shares Issued in Connection with Kolltan Severance |  | 344 |  |  | 344
Shares Issued in Connection with Kolltan Severance (in shares) | 107,175 |  |  |  |
Share-Based Compensation |  | 12,312 |  |  | 12,312
Unrealized Gains (Losses) on Marketable Securities |  |  | 23 |  | 23
Net Loss |  |  |  | (93,031) | (93,031)
Period End Balance at Dec. 31, 2017 | $ 139 | $ 1,046,183 | $ 2,564 | $ (812,517) | $ 236,369
Balance (in shares) at Dec. 31, 2017 | 138,520,404 |  |  |  | 138,520,404

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