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STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
REVENUES: |  |  |
Product Development and Licensing Agreements | $ 3,153 | $ 2,174 | $ 1,442
Contracts and Grants | 9,590 | 4,612 | 4,038
Total Revenues | 12,743 | 6,786 | 5,480
OPERATING EXPENSES: |  |  |
Research and Development | 96,171 | 102,726 | 100,171
General and Administrative | 25,003 | 35,979 | 33,837
In-Process Research and Development Impairment | 13,000 |  |
Gain on Fair Value Remeasurement of Contingent Consideration | (800) |  |
Amortization of Acquired Intangible Assets | 896 | 997 | 1,013
Total Operating Expenses | 134,270 | 139,702 | 135,021
Operating Loss | (121,527) | (132,916) | (129,541)
Investment and Other Income, Net | 4,214 | 4,386 | 2,344
Net Loss Before Income Tax Benefit | (117,313) | (128,530) | (127,197)
Income Tax Benefit | 24,282 |  |
Net Loss | $ (93,031) | $ (128,530) | $ (127,197)
Basic and Diluted Net Loss Per Common Share (in dollars per share) | $ (0.72) | $ (1.27) | $ (1.31)
Shares Used in Calculating Basic and Diluted Net Loss per Share (in shares) | 128,543 | 101,529 | 97,051
COMPREHENSIVE LOSS: |  |  |
Net Loss | $ (93,031) | $ (128,530) | $ (127,197)
Other Comprehensive Income (Loss): |  |  |
Foreign Currency Translation Adjustments |  |  | 15
Unrealized Gain (Loss) on Marketable Securities | 23 | 234 | (298)
Comprehensive Loss | $ (93,008) | $ (128,296) | $ (127,480)

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