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STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Cash Flows From Operating Activities: |  |  |
Net Loss | $ (93,031) | $ (128,530) | $ (127,197)
Adjustments to Reconcile Net Loss to Net Cash Used in Operating Activities: |  |  |
Depreciation and Amortization | 4,414 | 3,095 | 2,998
Amortization of Intangible Assets | 896 | 997 | 1,013
Amortization and Premium of Marketable Securities, Net | (290) | 926 | 350
Loss on Sale or Disposal of Assets | 55 | 81 |
In-Process Research and Development Impairment | 13,000 |  |
Gain on Fair Value Remeasurement of Contingent Consideration | (800) |  |
Non-Cash Income Tax Benefit | (24,282) |  |
Stock-Based Compensation Expense | 12,312 | 15,317 | 12,774
Non-Cash Expense |  | 1,638 | 288
Changes in Operating Assets and Liabilities: |  |  |
Accounts and Other Receivables | (96) | (814) | (543)
Prepaid and Other Current Assets | 793 | 1,320 | (653)
Other Assets | 205 | (89) | 6
Accounts Payable and Accrued Expenses | (8,744) | (4,970) | 4,875
Other Liabilities | (4,363) | (2,007) | 7,202
Net Cash Used in Operating Activities | (99,931) | (113,036) | (98,887)
Cash Flows From Investing Activities: |  |  |
Sales and Maturities of Marketable Securities | 219,236 | 242,792 | 161,090
Purchases of Marketable Securities | (170,980) | (173,925) | (206,405)
Investment in Other |  | (1,801) |
Cash Acquired in Kolltan Acquisition, Net |  | 4,592 |
Acquisition of Property and Equipment | (1,788) | (2,751) | (4,876)
Net Cash Provided by (Used in) Investing Activities | 46,468 | 68,907 | (50,191)
Cash Flows From Financing Activities: |  |  |
Net Proceeds from Stock Issuances | 51,025 | 13,946 | 188,840
Proceeds from Issuance of Stock from Employee Benefit Plans | 265 | 536 | 4,311
Net Cash Provided by Financing Activities | 51,290 | 14,482 | 193,151
Effect of Exchange Rate Changes on Cash and Cash Equivalents |  |  | 15
Net (Decrease) Increase in Cash and Cash Equivalents | (2,173) | (29,647) | 44,088
Cash and Cash Equivalents at Beginning of Period | 42,461 | 72,108 | 28,020
Cash and Cash Equivalents at End of Period | 40,288 | 42,461 | 72,108
Non-cash Investing Activities |  |  |
Accrued construction in progress | 20 | 159 | $ 75
Non-cash Supplemental Disclosure |  |  |
Shares issued to former Kolltan executive for settlement of severance | $ 344 | 426 |
Shares issued in connection with Kolltan Acquisition |  | $ 73,397 |

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- Definition The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- Definition The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- Definition Amount of cash inflow (outflow) from financing activities, including discontinued operations. Financing activity cash flows include obtaining resources from owners and providing them with a return on, and a return of, their investment; borrowing money and repaying amounts borrowed, or settling the obligation; and obtaining and paying for other resources obtained from creditors on long-term credit. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 24 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3521-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 26 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3574-108585 + Details
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- Definition Amount of cash inflow (outflow) from investing activities, including discontinued operations. Investing activity cash flows include making and collecting loans and acquiring and disposing of debt or equity instruments and property, plant, and equipment and other productive assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 24 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3521-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 26 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3574-108585 + Details
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- Definition Net income after adjustments for dividends on preferred stock (declared in the period) and/or cumulative preferred stock (accumulated for the period). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=64863997&loc=d3e1377-109256 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the aggregate amount received by the entity through sale or maturity of marketable securities (held-to-maturity or available-for-sale) during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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