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Nature of Business and Overview - (Details) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2017 USD ($) | Sep. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Sep. 30, 2016 USD ($) | Jun. 30, 2016 USD ($) | Mar. 31, 2016 USD ($) | Dec. 31, 2017 USD ($) Program product | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($)
Nature of Business and Overview |  |  |  |  |  |  |  |  |  |  |
Number of drug candidates in clinical development | product |  |  |  |  |  |  |  |  | 7 |  |
Cash, cash equivalents and marketable securities | $ 139,400 |  |  |  |  |  |  |  | $ 139,400 |  |
Net Loss | $ (3,841) | $ (26,363) | $ (28,566) | $ (34,261) | $ (32,307) | $ (29,598) | $ (31,952) | $ (34,673) | (93,031) | $ (128,530) | $ (127,197)
Net cash used in operations |  |  |  |  |  |  |  |  | $ 99,931 | $ 113,036 | $ 98,887
Minimum number of programs at risk due to fund restriction | Program |  |  |  |  |  |  |  |  | 1 |  |

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