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Collaboration Agreements (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Collaborative Agreements |  |  |
License fee expense | $ 0.7 | $ 0.7 | $ 1.6
Type of cost of goods sold line item | us-gaap:LicenseMember | us-gaap:LicenseMember | us-gaap:LicenseMember
Southampton |  |  |
Collaborative Agreements |  |  |
Potential milestone payment | $ 1.0 |  |
Amgen |  |  |
Collaborative Agreements |  |  |
Potential milestone payment | 0.9 |  |
Yale |  |  |
Collaborative Agreements |  |  |
Potential milestone payment | 3.0 |  |
MedImmune | Obtaining specified regulatory and development |  |  |
Collaborative Agreements |  |  |
Potential milestone payment | 45.0 |  |
MedImmune | Specified annual net sales thresholds are met |  |  |
Collaborative Agreements |  |  |
Potential milestone payment | $ 125.0 |  |

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- Definition For contingent consideration arrangements recognized in connection with a business combination, this element represents an estimate of the high-end of the potential range (undiscounted) of the consideration which may be paid. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 30 -Section 50 -Paragraph 1 -Subparagraph (c)(3) -URI http://asc.fasb.org/extlink&oid=35744584&loc=d3e6927-128479 + Details
Name: | us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
Name: | us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- Definition The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.2(a),(d)) -URI http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227 + Details
Name: | us-gaap_CostOfGoodsAndServicesSold
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Indicates type of cost of good or service sold. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 55 -Paragraph 91 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=108792157&loc=SL49130690-203046-203046 + Details
Name: | us-gaap_TypeOfCostGoodOrServiceExtensibleList
Namespace Prefix: | us-gaap_
Data Type: | srt-types:extensibleListItemType
Balance Type: | na
Period Type: | duration

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- Details
Name: | srt_MajorCustomersAxis=cldx_UniversityOfSouthamptonUKMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | srt_MajorCustomersAxis=cldx_AmgenIncMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | srt_MajorCustomersAxis=cldx_YaleUniversityMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | srt_MajorCustomersAxis=cldx_MedimmuneLlcMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | us-gaap_ContingentConsiderationByTypeAxis=cldx_ObtainingSpecifiedRegulatoryAndDevelopmentMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | us-gaap_ContingentConsiderationByTypeAxis=cldx_SpecifiedAnnualNetSalesThresholdsAreMetMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |