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Income Taxes - Deferred Tax (Details) - USD ($) $ in Thousands |  | 12 Months Ended
--- | --- | ---
Dec. 22, 2017 | Dec. 31, 2018 | Dec. 31, 2017
Gross Deferred Tax Assets |  |  |
Net Operating Loss Carryforwards |  | $ 168,239 | $ 146,228
Foreign Net Operating Loss Carryforwards |  | 4,485 | 3,572
Tax Credit Carryforwards |  | 39,761 | 36,458
Deferred Research and Development Expenses |  | 76,555 | 79,272
Stock-based Compensation |  | 11,977 | 10,718
Fixed Assets |  | 1,761 | 1,305
Deferred Revenue |  | 13 | 686
Accrued Expenses and Other |  | 183 | 316
Deferred Tax Assets, Gross |  | 302,974 | 278,555
Gross Deferred Tax Liabilities |  |  |
Other Acquired Intangibles |  | 120 | (1,792)
IPR&D Intangibles |  | (12,748) | (15,992)
Total Deferred Tax Assets and Liabilities |  | 290,346 | 260,771
Valuation Allowance |  | (293,353) | (264,543)
Net Deferred Tax Liability |  | (3,007) | (3,772)
Principal components of the deferred tax assets and liabilities |  |  |
Increase in deferred tax and valuation allowance |  |  | $ 17,700
U.S. federal corporate income tax rate (as a percent) | 21.00% |  | 35.00%
U.S. federal corporate income tax net operating losses (as a percent) | 80.00% |  |
Change in tax rate, deferred tax liability benefit |  | 6,900 |
Additional income tax benefit leading to tax liabilities |  | 12,200 |
Revaluation of deferred tax asset |  | 99,500 |
Income tax expense (benefit) |  | $ (765) | $ (24,282)

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