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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2018
Stock-Based Compensation |
Summary of stock option activity |
|  |  |  | Weighted |  | Weighted
|  |  |  | Average |  | Average
|  |  |  | Exercise |  | Remaining
|  |  |  | Price |  | Contractual
|  | Shares |  | Per Share |  | Term (In Years)
Options Outstanding at December 31, 2017 |  | 723,747 |  | $ | 141.00 |  | 6.1
Granted |  | 338,517 |  | $ | 9.11 |  |
Exercised |  | (6,967) |  | $ | 42.00 |  |
Canceled |  | (189,165) |  | $ | 125.38 |  |
Options Outstanding at December 31, 2018 |  | 866,132 |  | $ | 93.70 |  | 7.1
Options Vested and Expected to Vest at December 31, 2018 |  | 846,352 |  | $ | 95.47 |  | 7.0
Options Exercisable at December 31, 2018 |  | 426,612 |  | $ | 162.83 |  | 5.1
Shares Available for Grant Under the 2008 Plan |  | 356,913 |  |  |  |  |
Summary of restricted stock activity |
|  |  |  | Weighted
|  |  |  | Average
|  |  |  | Grant Date
|  |  |  | Fair Value
|  | Shares |  | (per share)
Outstanding and unvested at December 31, 2017 |  | 6,445 |  | $ | 44.70
Granted |  | — |  | $ | —
Vested |  | (2,449) |  | $ | 47.94
Canceled |  | (444) |  | $ | 34.83
Outstanding and unvested at December 31, 2018 |  | 3,552 |  | $ | 43.84
Schedule of stock-based compensation expense |
|  | 2018 |  | 2017 |  | 2016
|  | (In thousands)
Research and development |  | $ | 3,874 |  | $ | 6,693 |  | $ | 7,821
General and administrative |  |  | 4,207 |  |  | 5,619 |  |  | 7,496
Total stock-based compensation expense |  | $ | 8,081 |  | $ | 12,312 |  | $ | 15,317
Schedule of assumptions used for the fair value of employee stock options granted |
|  | 2018 |  | 2017 |  | 2016
Expected stock price volatility |  | 73 - 85% |  | 75 - 77% |  | 70 - 77%
Expected option term |  | 6.0 Years |  | 6.0 Years |  | 6.0 Years
Risk-free interest rate |  | 2.8 - 3.1% |  | 2.0 - 2.3% |  | 1.4 - 2.3%
Expected dividend yield |  | None |  | None |  | None

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=115993241&loc=d3e301413-122809 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901 + Details
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- Definition Tabular disclosure of the changes in outstanding nonvested shares. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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