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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
REVENUES: |  |  |
Total Revenues | $ 9,538 | $ 12,743 | $ 6,786
OPERATING EXPENSES: |  |  |
Research and Development | 66,449 | 96,171 | 102,726
General and Administrative | 19,269 | 25,003 | 35,979
Goodwill Impairment | 90,976 |  |
Intangible Asset Impairment | 18,677 | 13,000 |
Gain on Fair Value Remeasurement of Contingent Consideration | (29,621) | (800) |
Amortization of Acquired Intangible Assets | 224 | 896 | 997
Total Operating Expenses | 165,974 | 134,270 | 139,702
Operating Loss | (156,436) | (121,527) | (132,916)
Investment and Other Income, Net | 4,487 | 4,214 | 4,386
Net Loss Before Income Tax Benefit | (151,949) | (117,313) | (128,530)
Income Tax Benefit | 765 | 24,282 |
Net Loss | $ (151,184) | $ (93,031) | $ (128,530)
Basic and Diluted Net Loss Per Common Share (in dollars per share) | $ (14.48) | $ (10.86) | $ (18.99)
Shares Used in Calculating Basic and Diluted Net Loss Per Share (in shares) | 10,442 | 8,570 | 6,769
COMPREHENSIVE LOSS: |  |  |
Net Loss | $ (151,184) | $ (93,031) | $ (128,530)
Other Comprehensive Income (Loss): |  |  |
Unrealized Gain (Loss) on Marketable Securities | 19 | 23 | 234
Comprehensive Loss | (151,165) | (93,008) | (128,296)
Product Development and Licensing Agreements |  |  |
REVENUES: |  |  |
Total Revenues | 3,341 | 3,153 | 2,174
Contracts and Grants |  |  |
REVENUES: |  |  |
Total Revenues | $ 6,197 | $ 9,590 | $ 4,612

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