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Nature of Business and Overview - (Details) $ in Thousands |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Feb. 08, 2019 | Dec. 31, 2018 USD ($) | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Sep. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2018 USD ($) product | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
Nature of Business and Overview |  |  |  |  |  |  |  |  |  |  |  |
Number of drug candidates in clinical development | product |  |  |  |  |  |  |  |  |  | 4 |  |
Cash, cash equivalents and marketable securities |  | $ 94,000 |  |  |  |  |  |  |  | $ 94,000 |  |
Net Loss |  | $ (9,402) | $ (7,243) | $ (16,407) | $ (118,132) | $ (3,841) | $ (26,363) | $ (28,566) | $ (34,261) | (151,184) | $ (93,031) | $ (128,530)
Net cash used in operations |  |  |  |  |  |  |  |  |  | $ 75,235 | $ 99,931 | $ 113,036
Reverse stock split | 0.067 |  |  |  |  |  |  |  |  |  |  |

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