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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Cash Flows From Operating Activities: |  |  |
Net Loss | $ (50,878) | $ (151,184) | $ (93,031)
Adjustments to Reconcile Net Loss to Net Cash Used in Operating Activities: |  |  |
Depreciation and Amortization | 4,858 | 3,577 | 4,414
Amortization of Intangible Assets |  | 224 | 896
Amortization and Premium of Marketable Securities, Net | (1,140) | (1,048) | (290)
Loss on Sale or Disposal of Assets | 11 | 1,220 | 55
Goodwill Impairment |  | 90,976 |
Intangible Asset Impairment |  | 18,677 | 13,000
Other Asset Impairment | 1,800 |  |
Gain on Fair Value Remeasurement of Contingent Consideration | (1,294) | (29,621) | (800)
Non-Cash Income Tax Benefit |  | (765) | (24,282)
Stock-Based Compensation Expense | 4,551 | 8,081 | 12,312
Changes in Operating Assets and Liabilities: |  |  |
Accounts and Other Receivables | 2,274 | (777) | (96)
Prepaid and Other Current Assets | 362 | 1,783 | 793
Other Assets | (39) |  | 205
Accounts Payable and Accrued Expenses | (321) | (13,110) | (8,744)
Other Liabilities | (6,599) | (3,268) | (4,363)
Net Cash Used in Operating Activities | (46,415) | (75,235) | (99,931)
Cash Flows From Investing Activities: |  |  |
Sales and Maturities of Marketable Securities | 113,173 | 201,469 | 219,236
Purchases of Marketable Securities | (95,382) | (171,182) | (170,980)
Acquisition of Property and Equipment | (731) | (813) | (1,788)
Proceeds from Sale or Disposal of Assets | 20 | 342 |
Net Cash Provided by Investing Activities | 17,080 | 29,816 | 46,468
Cash Flows From Financing Activities: |  |  |
Net Proceeds from Stock Issuances | 16,248 | 29,022 | 51,025
Proceeds from Issuance of Stock from Employee Benefit Plans | 9 | 419 | 265
Net Cash Provided by Financing Activities | 16,257 | 29,441 | 51,290
Net Decrease in Cash and Cash Equivalents | (13,078) | (15,978) | (2,173)
Cash and Cash Equivalents at Beginning of Period | 24,310 | 40,288 | 42,461
Cash and Cash Equivalents at End of Period | 11,232 | 24,310 | 40,288
Non-cash Investing Activities |  |  |
Accrued construction in progress | $ 25 | 107 | 20
Non-cash Supplemental Disclosure |  |  |
Shares issued to former Kolltan executive for settlement of severance |  | $ 71 | $ 344

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- Definition The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3602-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3602-108585 + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- References No definition available. + Details
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Period Type: | duration