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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income. | Accumulated Deficit | Total
--- | --- | --- | --- | --- | ---
Period Start Balance at Dec. 31, 2016 | $ 8 | $ 982,368 | $ 2,541 | $ (719,486) | $ 265,431
Balance (in shares) at Dec. 31, 2016 | 8,034,443 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans |  | 265 |  |  | 265
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) | 11,581 |  |  |  |
Shares Issued in Connection with Cantor Agreement | $ 1 | 51,024 |  |  | 51,025
Shares Issued in Connection with Cantor Agreement (in shares) | 1,181,524 |  |  |  |
Shares Issued in Connection with Kolltan Severance |  | 344 |  |  | 344
Shares Issued in Connection with Kolltan Severance (in shares) | 7,145 |  |  |  |
Share-Based Compensation |  | 12,312 |  |  | 12,312
Unrealized Gains on Marketable Securities |  |  | 23 |  | 23
Net Loss |  |  |  | (93,031) | (93,031)
Period End Balance at Dec. 31, 2017 | $ 9 | 1,046,313 | 2,564 | (812,517) | 236,369
Balance (in shares) at Dec. 31, 2017 | 9,234,693 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans |  | 419 |  |  | 419
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) | 16,047 |  |  |  |
Shares Issued in Connection with Cantor Agreement | $ 3 | 29,019 |  |  | 29,022
Shares Issued in Connection with Cantor Agreement (in shares) | 2,702,660 |  |  |  |
Shares Issued in Connection with Kolltan Severance |  | 71 |  |  | 71
Shares Issued in Connection with Kolltan Severance (in shares) | 4,235 |  |  |  |
Share-Based Compensation |  | 8,081 |  |  | 8,081
Unrealized Gains on Marketable Securities |  |  | 19 |  | 19
Adoption of ASC 606 |  |  |  | 1,263 | 1,263
Net Loss |  |  |  | (151,184) | (151,184)
Period End Balance at Dec. 31, 2018 | $ 12 | 1,083,903 | 2,583 | (962,438) | $ 124,060
Balance (in shares) at Dec. 31, 2018 | 11,957,635 |  |  |  | 11,957,635
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares Issued under Stock Option and Employee Stock Purchase Plans |  | 9 |  |  | $ 9
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) | 3,285 |  |  |  |
Shares Issued in Connection with Cantor Agreement | $ 5 | 16,243 |  |  | 16,248
Shares Issued in Connection with Cantor Agreement (in shares) | 5,011,157 |  |  |  |
Share-Based Compensation |  | 4,551 |  |  | 4,551
Unrealized Gains on Marketable Securities |  |  | 36 |  | 36
Net Loss |  |  |  | (50,878) | (50,878)
Period End Balance at Dec. 31, 2019 | $ 17 | $ 1,104,706 | $ 2,619 | $ (1,013,316) | $ 94,026
Balance (in shares) at Dec. 31, 2019 | 16,972,077 |  |  |  | 16,972,077

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