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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
REVENUES: |  |  |
Total Revenues | $ 3,573 | $ 9,538 | $ 12,743
OPERATING EXPENSES: |  |  |
Research and Development | 42,672 | 66,449 | 96,171
General and Administrative | 15,426 | 19,269 | 25,003
Goodwill Impairment |  | 90,976 |
Intangible Asset Impairment |  | 18,677 | 13,000
Other Asset Impairment | 1,800 |  |
Gain on Fair Value Remeasurement of Contingent Consideration | (1,294) | (29,621) | (800)
Amortization of Acquired Intangible Assets |  | 224 | 896
Total Operating Expenses | 58,604 | 165,974 | 134,270
Operating Loss | (55,031) | (156,436) | (121,527)
Investment and Other Income, Net | 4,153 | 4,487 | 4,214
Net Loss Before Income Tax Benefit | (50,878) | (151,949) | (117,313)
Income Tax Benefit |  | 765 | 24,282
Net Loss | $ (50,878) | $ (151,184) | $ (93,031)
Basic and Diluted Net Loss Per Common Share | $ (3.51) | $ (14.48) | $ (10.86)
Shares Used in Calculating Basic and Diluted Net Loss per Share | 14,507 | 10,442 | 8,570
COMPREHENSIVE LOSS: |  |  |
Net Loss | $ (50,878) | $ (151,184) | $ (93,031)
Other Comprehensive Income (Loss): |  |  |
Unrealized Gain on Marketable Securities | 36 | 19 | 23
Comprehensive Loss | (50,842) | (151,165) | (93,008)
Product Development and Licensing Agreements |  |  |
REVENUES: |  |  |
Total Revenues | 473 | 3,341 | 3,153
Contracts and Grants |  |  |
REVENUES: |  |  |
Total Revenues | $ 3,100 | $ 6,197 | $ 9,590

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