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Stock-Based Compensation - Expenses (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Stock-based compensation expense |  |  |
Stock-based compensation expense | $ 4,551 | $ 8,081 | $ 12,312
Research and development |  |  |
Stock-based compensation expense |  |  |
Stock-based compensation expense | 2,053 | 3,874 | 6,693
General and administrative |  |  |
Stock-based compensation expense |  |  |
Stock-based compensation expense | $ 2,498 | $ 4,207 | $ 5,619

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