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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Revenues: |  |  |
Total revenues | $ 7,418 | $ 3,573 | $ 9,538
Operating expenses: |  |  |
Research and development | 42,534 | 42,672 | 66,449
General and administrative | 14,456 | 15,426 | 19,269
Goodwill impairment |  |  | 90,976
Intangible asset impairment | 18,000 |  | 18,677
Other asset impairment |  | 1,800 |
Gain on fair value remeasurement of contingent consideration | (4,218) | (1,294) | (29,621)
Amortization of acquired intangible assets | 0 | 0 | 224
Total operating expenses | 70,772 | 58,604 | 165,974
Operating loss | (63,354) | (55,031) | (156,436)
Investment and other income, net | 2,407 | 4,153 | 4,487
Net loss before income tax benefit | (60,947) | (50,878) | (151,949)
Income tax benefit | 1,167 |  | 765
Net loss | $ (59,780) | $ (50,878) | $ (151,184)
Basic and diluted net loss per common share | $ (2.02) | $ (3.51) | $ (14.48)
Shares used in calculating basic and diluted net loss per share | 29,640 | 14,507 | 10,442
Comprehensive loss: |  |  |
Net loss | $ (59,780) | $ (50,878) | $ (151,184)
Other comprehensive income (loss): |  |  |
Unrealized (loss) gain on marketable securities | (30) | 36 | 19
Comprehensive loss | (59,810) | (50,842) | (151,165)
Product development and licensing agreements |  |  |
Revenues: |  |  |
Total revenues | 2,301 | 473 | 3,341
Contracts and grants |  |  |
Revenues: |  |  |
Total revenues | $ 5,117 | $ 3,100 | $ 6,197

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