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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Cash flows from operating activities: |  |  |
Net loss | $ (59,780) | $ (50,878) | $ (151,184)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 3,929 | 4,858 | 3,577
Amortization of intangible assets | 0 | 0 | 224
Amortization and premium of marketable securities, net | (729) | (1,140) | (1,048)
(Gain) loss on sale or disposal of assets | (55) | 11 | 1,220
Goodwill impairment |  |  | 90,976
Intangible asset impairment | 18,000 |  | 18,677
Other asset impairment |  | 1,800 |
Gain on fair value remeasurement of contingent consideration | (4,218) | (1,294) | (29,621)
Non-cash income tax benefit | (1,167) |  | (765)
Stock-based compensation expense | 3,915 | 4,551 | 8,081
Changes in operating assets and liabilities: |  |  |
Accounts and other receivables | (787) | 2,274 | (777)
Prepaid and other current assets | (334) | 362 | 1,783
Other assets |  | (39) |
Accounts payable and accrued expenses | 1,638 | (321) | (13,110)
Other liabilities | (816) | (6,599) | (3,268)
Net cash used in operating activities | (40,404) | (46,415) | (75,235)
Cash flows from investing activities: |  |  |
Sales and maturities of marketable securities | 123,600 | 113,173 | 201,469
Purchases of marketable securities | (220,321) | (95,382) | (171,182)
Acquisition of property and equipment | (1,552) | (731) | (813)
Proceeds from sale or disposal of assets | 55 | 20 | 342
Net cash (used in) provided by investing activities | (98,218) | 17,080 | 29,816
Cash flows from financing activities: |  |  |
Net proceeds from stock issuances | 170,792 | 16,248 | 29,022
Proceeds from issuance of stock from employee benefit plans | 434 | 9 | 419
Issuance of term loan | 2,962 |  |
Payment of term loan | (2,962) |  |
Net cash provided by financing activities | 171,226 | 16,257 | 29,441
Net increase (decrease) in cash and cash equivalents | 32,604 | (13,078) | (15,978)
Cash and cash equivalents at beginning of period | 11,232 | 24,310 | 40,288
Cash and cash equivalents at end of period | 43,836 | 11,232 | 24,310
Non-cash investing activities |  |  |
Accrued construction in progress | $ 221 | $ 25 | 107
Non-cash supplemental disclosure |  |  |
Shares issued to former Kolltan executive for settlement of severance |  |  | $ 71

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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash outflow during the period from the repayment of aggregate short-term and long-term debt. Excludes payment of capital lease obligations. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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- Definition The fair value of stock issued in noncash financing activities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4304-108586 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4332-108586 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4313-108586 + Details
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