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Nature of Business and Overview (Details) $ in Thousands |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Feb. 08, 2019 | Dec. 31, 2020 USD ($) | Sep. 30, 2020 USD ($) | Jun. 30, 2020 USD ($) | Mar. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Sep. 30, 2019 USD ($) | Jun. 30, 2019 USD ($) | Mar. 31, 2019 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($)
Nature of Business and Overview |  |  |  |  |  |  |  |  |  |  |  |
Reverse stock split | 0.067 |  |  |  |  |  |  |  |  |  |  |
Cash, cash equivalents and marketable securities |  | $ 194,400 |  |  |  |  |  |  |  | $ 194,400 |  |
Net loss |  | (21,900) | $ (14,224) | $ (11,031) | $ (12,625) | $ (10,447) | $ (11,413) | $ (11,779) | $ (17,239) | (59,780) | $ (50,878) | $ (151,184)
Net cash used in operations |  |  |  |  |  |  |  |  |  | (40,404) | (46,415) | $ (75,235)
Gross carrying amount of indefinite-lived |  | $ 30,700 |  |  |  | $ 48,700 |  |  |  | $ 30,700 | $ 48,700 |

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