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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOW - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Cash flows from operating activities: |  |
Net loss | $ (50,363) | $ (37,880)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 2,291 | 3,174
Amortization and premium of marketable securities, net | (3,407) | (422)
Gain on sale or disposal of assets | (23) | (29)
Intangible Asset Impairment | 3,500 | 3,500
Gain on fair value remeasurement of contingent consideration | (1,160) | (4,236)
Non-Cash Income Tax Benefit | (227) | (228)
Stock-based compensation expense | 5,813 | 2,658
Changes in operating assets and liabilities: |  |
Accounts and other receivables | 1,549 | 177
Prepaid and other current assets | (2,261) | (1,280)
Accounts payable and accrued expenses | 1,757 | 864
Other liabilities | (3,855) | (1,491)
Net cash used in operating activities | (46,386) | (35,193)
Cash flows from investing activities: |  |
Sales and maturities of marketable securities | 129,000 | 55,600
Purchases of marketable securities | (325,342) | (183,394)
Acquisition of property and equipment | (895) | (1,305)
Proceeds from sale or disposal of assets | 25 | 29
Net cash used in investing activities | (197,212) | (129,070)
Cash flows from financing activities: |  |
Net proceeds from stock issuances | 269,893 | 170,964
Proceeds from issuance of stock from employee benefit plans | 2,053 | 218
Issuance of Term Loan |  | 2,962
Payment of Term Loan |  | (2,962)
Net cash provided by financing activities | 271,946 | 171,182
Net increase in cash and cash equivalents | 28,348 | 6,919
Cash and cash equivalents at beginning of period | 43,836 | 11,232
Cash and cash equivalents at end of period | 72,184 | 18,151
Non-cash investing activities |  |
Accrued construction in progress | $ 46 | $ 63

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- Definition The cash outflow during the period from the repayment of aggregate short-term and long-term debt. Excludes payment of capital lease obligations. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3291-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3602-108585 + Details
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