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Stockholders' Equity (Tables) | 9 Months Ended
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Sep. 30, 2021
Stockholders' Equity |
Schedule of Shareholder's equity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | ​ | ​ |  | ​ | ​ |  | Accumulated |  | ​ | ​ |  | ​ | ​
​ | ​ | Common | ​ | Common | ​ | Additional | ​ | Other | ​ | ​ | ​ | ​ | Total
​ | ​ | Stock | ​ | Stock Par | ​ | Paid-In | ​ | Comprehensive | ​ | Accumulated | ​ | Stockholders’
​ | ​ | Shares | ​ | Value | ​ | Capital | ​ | Income | ​ | Deficit | ​ | Equity
​ | ​ | (In thousands, except share amounts)
Consolidated balance at December 31, 2020 |  | 39,603,771 |  | $ | 40 |  | $ | 1,279,824 |  | $ | 2,589 |  | $ | (1,073,096) |  | $ | 209,357
Shares issued under stock option and employee stock purchase plans |  | 10,867 |  |  | — |  |  | 74 |  |  | — |  |  | — |  |  | 74
Stock-based compensation |  | — |  |  | — |  |  | 1,275 |  |  | — |  |  | — |  |  | 1,275
Unrealized loss on marketable securities |  | — |  |  | — |  |  | — |  |  | (2) |  |  | — |  |  | (2)
Net loss |  | — |  |  | — |  |  | — |  |  | — |  |  | (16,538) |  |  | (16,538)
Consolidated balance at March 31, 2021 |  | 39,614,638 |  | $ | 40 |  | $ | 1,281,173 |  | $ | 2,587 |  | $ | (1,089,634) |  | $ | 194,166
Shares issued under stock option and employee stock purchase plans |  | 2,058 |  |  | — |  |  | (25) |  |  | — |  |  | — |  |  | (25)
Stock-based compensation |  | — |  |  | — |  |  | 1,509 |  |  | — |  |  | — |  |  | 1,509
Unrealized gain on marketable securities |  | — |  |  | — |  |  | — |  |  | 5 |  |  | — |  |  | 5
Net loss |  | — |  |  | — |  |  | — |  |  | — |  |  | (13,373) | ​ |  | (13,373)
Consolidated balance at June 30, 2021 |  | 39,616,696 | ​ | $ | 40 | ​ | $ | 1,282,657 | ​ | $ | 2,592 | ​ | $ | (1,103,007) | ​ | $ | 182,282
Shares issued under stock option and employee stock purchase plans | ​ | 201,406 | ​ | ​ | — | ​ | ​ | 2,004 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 2,004
Shares issued in underwritten offering, net | ​ | 6,845,238 | ​ | ​ | 7 | ​ | ​ | 269,886 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 269,893
Stock-based compensation | ​ | — | ​ | ​ | — | ​ | ​ | 3,029 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 3,029
Unrealized loss on marketable securities | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (44) | ​ | ​ | — | ​ | ​ | (44)
Net loss | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (20,452) | ​ | ​ | (20,452)
Consolidated balance at September 30, 2021 | ​ | 46,663,340 | ​ | $ | 47 | ​ | $ | 1,557,576 | ​ | $ | 2,548 | ​ | $ | (1,123,459) | ​ | $ | 436,712
​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | ​ | ​ |  | ​ | ​ |  | Accumulated |  | ​ | ​ |  | ​ | ​
​ | ​ | Common | ​ | Common | ​ | Additional | ​ | Other | ​ | ​ | ​ | ​ | Total
​ | ​ | Stock | ​ | Stock Par | ​ | Paid-In | ​ | Comprehensive | ​ | Accumulated | ​ | Stockholders’
​ | ​ | Shares | ​ | Value | ​ | Capital | ​ | Income | ​ | Deficit | ​ | Equity
​ | ​ | (In thousands, except share amounts)
Consolidated balance at December 31, 2019 |  | 16,972,077 | ​ | $ | 17 | ​ | $ | 1,104,706 | ​ | $ | 2,619 | ​ | $ | (1,013,316) | ​ | $ | 94,026
Shares issued under stock option and employee stock purchase plans |  | 12,573 | ​ |  | — | ​ |  | 24 | ​ |  | — | ​ |  | — | ​ |  | 24
Shares issued in connection with at the market agreement |  | 746,152 | ​ |  | 1 | ​ |  | 1,613 | ​ |  | — | ​ |  | — | ​ |  | 1,614
Stock-based compensation |  | — | ​ |  | — | ​ |  | 686 | ​ |  | — | ​ |  | — | ​ |  | 686
Unrealized loss on marketable securities |  | — | ​ |  | — | ​ |  | — | ​ |  | (22) | ​ |  | — | ​ |  | (22)
Net loss |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | (12,625) | ​ |  | (12,625)
Consolidated balance at March 31, 2020 |  | 17,730,802 | ​ | $ | 18 | ​ | $ | 1,107,029 | ​ | $ | 2,597 | ​ | $ | (1,025,941) | ​ | $ | 83,703
Shares issued in connection with at the market agreement |  | 5,978,452 | ​ |  | 6 | ​ |  | 23,686 | ​ |  | — | ​ |  | — | ​ |  | 23,692
Shares issued in underwritten offering, net |  | 15,384,614 | ​ |  | 15 | ​ |  | 141,346 | ​ |  | — | ​ |  | — | ​ |  | 141,361
Stock-based compensation |  | — | ​ |  | — | ​ |  | 722 | ​ |  | — | ​ |  | — | ​ |  | 722
Unrealized loss on marketable securities |  | — | ​ |  | — | ​ |  | — | ​ |  | (3) | ​ |  | — | ​ |  | (3)
Net loss |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | (11,031) | ​ |  | (11,031)
Consolidated balance at June 30, 2020 |  | 39,093,868 | ​ | $ | 39 | ​ | $ | 1,272,783 | ​ | $ | 2,594 | ​ | $ | (1,036,972) | ​ | $ | 238,444
Shares issued under stock option and employee stock purchase plans | ​ | 68,204 | ​ | ​ | — | ​ | ​ | 194 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 194
Shares issued in connection with at the market agreement | ​ | 400,400 | ​ | ​ | 1 | ​ | ​ | 4,296 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 4,297
Stock-based compensation | ​ | — | ​ | ​ | — | ​ | ​ | 1,250 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 1,250
Unrealized gain on marketable securities | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 14 | ​ | ​ | — | ​ | ​ | 14
Net loss | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (14,224) | ​ | ​ | (14,224)
Consolidated balance at September 30, 2020 | ​ | 39,562,472 | ​ | $ | 40 | ​ | $ | 1,278,523 | ​ | $ | 2,608 | ​ | $ | (1,051,196) | ​ | $ | 229,975

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- Definition Tabular disclosure of changes in the separate accounts comprising stockholders' equity (in addition to retained earnings) and of the changes in the number of shares of equity securities during at least the most recent annual fiscal period and any subsequent interim period presented is required to make the financial statements sufficiently informative if both financial position and results of operations are presented. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=109259400&loc=d3e21463-112644 + Details
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