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v3.21.2

Stockholders' Equity (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended
--- | --- | --- | ---
Jul. 31, 2021 | Sep. 30, 2021 | Jun. 30, 2021 | Mar. 31, 2021 | Sep. 30, 2020 | Jun. 30, 2020 | Mar. 31, 2020 | Sep. 30, 2021 | Sep. 30, 2020
Common Stock |  |  |  |  |  |  |  |  |
Balance | $ 182,282 | $ 182,282 | $ 194,166 | $ 209,357 | $ 238,444 | $ 83,703 | $ 94,026 | $ 209,357 | $ 94,026
Balance (in shares) |  |  |  | 39,603,771 |  |  |  | 39,603,771 |
Shares issued under stock option and employee stock purchase plans |  | 2,004 |  | $ 74 | 194 |  | 24 |  |
Shares issued under stock option and employee stock purchase plans |  |  | (25) |  |  |  |  |  |
Shares issued in connection with at the market agreement |  |  |  |  | 4,297 | 23,692 | 1,614 |  |
Shares issued in underwritten offering, net |  | 269,893 |  |  |  | 141,361 |  |  |
Stock-based compensation |  | 3,029 | 1,509 | 1,275 | 1,250 | 722 | 686 |  |
Unrealized (loss) gain on marketable securities |  | (44) | 5 | (2) | 14 | (3) | (22) | $ (41) | (11)
Net loss |  | (20,452) | (13,373) | (16,538) | (14,224) | (11,031) | (12,625) | (50,363) | (37,880)
Balance |  | $ 436,712 | 182,282 | 194,166 | 229,975 | 238,444 | 83,703 | $ 436,712 | 229,975
Balance (in shares) |  | 46,663,340 |  |  |  |  |  | 46,663,340 |
Aggregate gross offering price available |  | $ 50,000 |  |  |  |  |  | $ 50,000 |
Net proceeds from sale of common stock |  |  |  |  |  |  |  | 269,893 | 170,964
Underwritten Public Offering |  |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |
Common stock issued (in shares) | 6,845,238 |  |  |  |  |  |  |  |
Net proceeds from sale of common stock | $ 269,900 |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |
Balance | $ 40 | $ 40 | $ 40 | $ 40 | $ 39 | $ 18 | $ 17 | $ 40 | $ 17
Balance (in shares) | 39,616,696 | 39,616,696 | 39,614,638 | 39,603,771 | 39,093,868 | 17,730,802 | 16,972,077 | 39,603,771 | 16,972,077
Shares issued under stock option and employee stock purchase plans (in shares) |  | 201,406 |  | 10,867 | 68,204 |  | 12,573 |  |
Shares issued under stock option and employee stock purchase plans (in shares) |  |  | 2,058 |  |  |  |  |  |
Shares issued in connection with at the market agreement |  |  |  |  | $ 1 | $ 6 | $ 1 |  |
Shares issued in connection with at the market agreement (in shares) |  |  |  |  | 400,400 | 5,978,452 | 746,152 |  |
Shares issued in underwritten offering, net |  | $ 7 |  |  |  | $ 15 |  |  |
Shares issued in underwritten offering, net (in shares) |  | 6,845,238 |  |  |  | 15,384,614 |  |  |
Balance |  | $ 47 | $ 40 | $ 40 | $ 40 | $ 39 | $ 18 | $ 47 | $ 40
Balance (in shares) |  | 46,663,340 | 39,616,696 | 39,614,638 | 39,562,472 | 39,093,868 | 17,730,802 | 46,663,340 | 39,562,472
Additional Paid-In Capital |  |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |
Balance | $ 1,282,657 | $ 1,282,657 | $ 1,281,173 | $ 1,279,824 | $ 1,272,783 | $ 1,107,029 | $ 1,104,706 | $ 1,279,824 | $ 1,104,706
Shares issued under stock option and employee stock purchase plans |  | 2,004 |  | 74 | 194 |  | 24 |  |
Shares issued under stock option and employee stock purchase plans |  |  | (25) |  |  |  |  |  |
Shares issued in connection with at the market agreement |  |  |  |  | 4,296 | 23,686 | 1,613 |  |
Shares issued in underwritten offering, net |  | 269,886 |  |  |  | 141,346 |  |  |
Stock-based compensation |  | 3,029 | 1,509 | 1,275 | 1,250 | 722 | 686 |  |
Balance |  | 1,557,576 | 1,282,657 | 1,281,173 | 1,278,523 | 1,272,783 | 1,107,029 | 1,557,576 | 1,278,523
Accumulated Other Comprehensive Income |  |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |
Balance | 2,592 | 2,592 | 2,587 | 2,589 | 2,594 | 2,597 | 2,619 | 2,589 | 2,619
Unrealized (loss) gain on marketable securities |  | (44) | 5 | (2) | 14 | (3) | (22) |  |
Balance |  | 2,548 | 2,592 | 2,587 | 2,608 | 2,594 | 2,597 | 2,548 | 2,608
Accumulated Deficit |  |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |
Balance | $ (1,103,007) | (1,103,007) | (1,089,634) | (1,073,096) | (1,036,972) | (1,025,941) | (1,013,316) | (1,073,096) | (1,013,316)
Net loss |  | (20,452) | (13,373) | (16,538) | (14,224) | (11,031) | (12,625) |  |
Balance |  | $ (1,123,459) | $ (1,103,007) | $ (1,089,634) | $ (1,051,196) | $ (1,036,972) | $ (1,025,941) | $ (1,123,459) | $ (1,051,196)

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