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CONSOLIDATED STATEMENTS OF CASH FLOW - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities: |  |  |
Net loss | $ (70,511) | $ (59,780) | $ (50,878)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 3,068 | 3,929 | 4,858
Amortization and premium of marketable securities, net | (3,209) | (729) | (1,140)
(Gain) loss on sale or disposal of assets | (24) | (55) | 11
Intangible asset impairment | 3,500 | 18,000 |
Other asset impairment |  |  | 1,800
Gain on fair value remeasurement of contingent consideration | (1,405) | (4,218) | (1,294)
Non-cash income tax benefit | (227) | (1,167) |
Stock-based compensation expense | 8,953 | 3,915 | 4,551
Changes in operating assets and liabilities: |  |  |
Accounts and other receivables | 1,574 | (787) | 2,274
Prepaid and other current assets | (1,871) | (334) | 362
Other assets | (5) |  | (39)
Accounts payable and accrued expenses | 3,653 | 1,638 | (321)
Other liabilities | (4,405) | (816) | (6,599)
Net cash used in operating activities | (60,909) | (40,404) | (46,415)
Cash flows from investing activities: |  |  |
Sales and maturities of marketable securities | 174,947 | 123,600 | 113,173
Purchases of marketable securities | (389,881) | (220,321) | (95,382)
Acquisition of property and equipment | (1,249) | (1,552) | (731)
Proceeds from sale or disposal of assets | 27 | 55 | 20
Net cash (used in) provided by investing activities | (216,156) | (98,218) | 17,080
Cash flows from financing activities: |  |  |
Net proceeds from stock issuances | 269,893 | 170,792 | 16,248
Proceeds from issuance of stock from employee benefit plans | 2,479 | 434 | 9
Issuance of term loan |  | 2,962 |
Payment of term loan |  | (2,962) |
Net cash provided by financing activities | 272,372 | 171,226 | 16,257
Net (decrease) increase in cash and cash equivalents | (4,693) | 32,604 | (13,078)
Cash and cash equivalents at beginning of period | 43,836 | 11,232 | 24,310
Cash and cash equivalents at end of period | 39,143 | 43,836 | 11,232
Non-cash investing activities |  |  |
Accrued construction in progress | $ 289 | $ 221 | $ 25

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- Definition The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3602-108585 + Details
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- Definition The cash inflow during the period from additional borrowings in aggregate debt. Includes proceeds from short-term and long-term debt. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the aggregate amount received by the entity through sale or maturity of marketable securities (held-to-maturity or available-for-sale) during the period. + References No definition available. + Details
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- Definition The cash inflow from the sale of property, plant and equipment (capital expenditures), software, and other intangible assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3255-108585 + Details
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- Definition The cash outflow during the period from the repayment of aggregate short-term and long-term debt. Excludes payment of capital lease obligations. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3602-108585 + Details
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