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Property and Equipment, Net | 12 Months Ended
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Dec. 31, 2021
Property and Equipment, Net |
Property and Equipment, Net | (6) Property and Equipment, Net Property and Equipment, net includes the following: ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | December 31, |  | December 31,
​ | ​ | 2021 | ​ | 2020
​ | ​ | (In thousands)
Laboratory equipment | ​ | $ | 8,581 | ​ | $ | 8,566
Manufacturing equipment |  | ​ | 2,571 |  | ​ | 2,630
Office furniture and equipment |  | ​ | 3,362 |  | ​ | 3,409
Leasehold improvements |  | ​ | 9,531 |  | ​ | 10,103
Construction in progress |  | ​ | 632 |  | ​ | 344
Total property and equipment |  | ​ | 24,677 |  | ​ | 25,052
Less: accumulated depreciation and amortization |  | ​ | (21,126) |  | ​ | (21,237)
Property and equipment, net | ​ | $ | 3,551 | ​ | $ | 3,815
​ Depreciation and amortization expense related to property and equipment was $1.6 million, $2.0 million and $2.7 million for the years ended December 31, 2021, 2020 and 2019, respectively.

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- Definition The entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=120429125&loc=d3e99893-112916 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -URI http://asc.fasb.org/topic&trid=2155823 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 7 -URI http://asc.fasb.org/extlink&oid=120429125&loc=SL120174063-112916 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 1 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120429125&loc=d3e99779-112916 + Details
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