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Nature of Business and Overview (Details) $ in Thousands |  | 12 Months Ended
--- | --- | ---
Feb. 08, 2019 | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Nature of Business and Overview |  |  |  |
Reverse stock split | 0.067 |  |  |
Cash, cash equivalents and marketable securities |  | $ 408,300 |  |
Net loss |  | (70,511) | $ (59,780) | $ (50,878)
Net cash used in operations |  | (60,909) | (40,404) | $ (46,415)
Gross carrying amount of indefinite-lived |  | $ 27,200 | $ 30,700 |

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