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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income. | Accumulated Deficit | Total
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2018 | $ 12 | $ 1,083,903 | $ 2,583 | $ (962,438) | $ 124,060
Balance (in shares) at Dec. 31, 2018 | 11,957,635 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares issued under stock option and employee stock purchase plans |  | 9 |  |  | 9
Shares issued under stock option and employee stock purchase plans (in shares) | 3,285 |  |  |  |
Shares issued in connection with at the market agreement | $ 5 | 16,243 |  |  | 16,248
Shares issued in connection with at the market agreement (in shares) | 5,011,157 |  |  |  |
Stock-based compensation |  | 4,551 |  |  | 4,551
Unrealized gain (loss) on marketable securities |  |  | 36 |  | 36
Net loss |  |  |  | (50,878) | (50,878)
Balance at Dec. 31, 2019 | $ 17 | 1,104,706 | 2,619 | (1,013,316) | 94,026
Balance (in shares) at Dec. 31, 2019 | 16,972,077 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares issued under stock option and employee stock purchase plans |  | 434 |  |  | 434
Shares issued under stock option and employee stock purchase plans (in shares) | 122,076 |  |  |  |
Shares issued in connection with at the market agreement | $ 8 | 29,423 |  |  | 29,431
Shares issued in connection with at the market agreement (in shares) | 7,125,004 |  |  |  |
Shares issued in underwritten offering, net | $ 15 | 141,346 |  |  | 141,361
Shares issued in underwritten offering, net (in shares) | 15,384,614 |  |  |  |
Stock-based compensation |  | 3,915 |  |  | 3,915
Unrealized gain (loss) on marketable securities |  |  | (30) |  | (30)
Net loss |  |  |  | (59,780) | (59,780)
Balance at Dec. 31, 2020 | $ 40 | 1,279,824 | 2,589 | (1,073,096) | $ 209,357
Balance (in shares) at Dec. 31, 2020 | 39,603,771 |  |  |  | 39,603,771
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Shares issued under stock option and employee stock purchase plans |  | 2,479 |  |  | $ 2,479
Shares issued under stock option and employee stock purchase plans (in shares) | 281,189 |  |  |  |
Shares issued in underwritten offering, net | $ 7 | 269,886 |  |  | 269,893
Shares issued in underwritten offering, net (in shares) | 6,845,238 |  |  |  |
Stock-based compensation |  | 8,953 |  |  | 8,953
Unrealized gain (loss) on marketable securities |  |  | (695) |  | (695)
Net loss |  |  |  | (70,511) | (70,511)
Balance at Dec. 31, 2021 | $ 47 | $ 1,561,142 | $ 1,894 | $ (1,143,607) | $ 419,476
Balance (in shares) at Dec. 31, 2021 | 46,730,198 |  |  |  | 46,730,198

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