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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOW - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2022 | Jun. 30, 2021
Cash flows from operating activities: |  |
Net loss | $ (59,054) | $ (29,911)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 1,552 | 1,539
Amortization and premium of marketable securities, net | 1,308 | (173)
Loss (gain) on sale or disposal of assets | 57 | (24)
(Gain) loss on fair value remeasurement of contingent consideration | (6,862) | 741
Stock-based compensation expense | 6,607 | 2,784
Changes in operating assets and liabilities: |  |
Accounts and other receivables | 75 | 1,306
Prepaid and other current assets | (8,485) | (1,544)
Accounts payable and accrued expenses | (862) | (750)
Litigation settlement payable | 15,000 |
Other liabilities | 3,886 | (3,982)
Net cash used in operating activities | (46,778) | (30,014)
Cash flows from investing activities: |  |
Sales and maturities of marketable securities | 106,756 | 116,000
Purchases of marketable securities | (69,847) | (85,739)
Acquisition of property and equipment | (1,248) | (710)
Proceeds from sale or disposal of assets | 0 | 24
Net cash provided by investing activities | 35,661 | 29,575
Cash flows from financing activities: |  |
Proceeds from issuance of stock from employee benefit plans | 375 | 49
Net cash provided by financing activities | 375 | 49
Net decrease in cash and cash equivalents | (10,742) | (390)
Cash and cash equivalents at beginning of period | 39,143 | 43,836
Cash and cash equivalents at end of period | 28,401 | $ 43,446
Non-cash investing activities |  |
Accrued construction in progress | $ 54 |

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