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Stock-Based Compensation (Tables) | 6 Months Ended
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Jun. 30, 2022
Stock-Based Compensation |
Schedule of stock option activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | Weighted | ​ | Weighted
​ | ​ | ​ | ​ | Average | ​ | Average
​ | ​ | ​ | ​ | Exercise | ​ | Remaining
​ | ​ | ​ | ​ | Price | ​ | Contractual
​ |  | Shares |  | Per Share |  | Term (In Years)
Options outstanding at December 31, 2021 |  | 4,077,667 | ​ | $ | 30.02 | ​ | 8.0
Granted |  | 1,570,900 | ​ | $ | 22.79 | ​ | ​
Exercised |  | (29,910) | ​ | $ | 8.05 | ​ | ​
Canceled |  | (28,444) | ​ | $ | 36.24 | ​ | ​
Options outstanding at June 30, 2022 |  | 5,590,213 | ​ | $ | 28.07 | ​ | 8.20
Options vested and expected to vest at June 30, 2022 |  | 5,428,921 | ​ | $ | 28.25 | ​ | 8.17
Options exercisable at June 30, 2022 |  | 2,135,506 | ​ | $ | 39.84 | ​ | 6.76
Shares available for grant under the 2021 Plan |  | 1,761,761 | ​ | ​ | ​ | ​ | ​
​
Schedule of stock-based compensation expense | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three months ended June 30, | ​ | Six months ended June 30,
​ |  | 2022 |  | 2021 |  | 2022 |  | 2021
​ | ​ | (In thousands) | ​ | (In thousands)
Research and development | ​ | $ | 1,798 | ​ | $ | 762 | ​ | $ | 3,412 | ​ | $ | 1,423
General and administrative | ​ |  | 1,656 | ​ |  | 747 | ​ |  | 3,195 | ​ |  | 1,361
Total stock-based compensation expense | ​ | $ | 3,454 | ​ | $ | 1,509 | ​ | $ | 6,607 | ​ | $ | 2,784
​
Schedule of assumptions used for the fair value of employee stock options granted | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three months ended June 30, | ​ | Six months ended June 30,
|  | 2022 |  | 2021 |  | 2022 |  | 2021
Expected stock price volatility |  | 90 – 91% | ​ | 97 – 98% | ​ | 90 – 97% | ​ | 97 – 98%
Expected option term |  | 6.0 Years | ​ | 6.0 Years | ​ | 6.0 Years | ​ | 6.0 Years
Risk-free interest rate |  | 2.7 – 3.6% | ​ | 1.2 – 1.3% | ​ | 1.7 – 3.6% | ​ | 0.8 – 1.3%
Expected dividend yield |  | None | ​ | None | ​ | None | ​ | None

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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