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v3.22.2.2

Stockholders' Equity (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2022 | Jun. 30, 2022 | Mar. 31, 2022 | Sep. 30, 2021 | Jun. 30, 2021 | Mar. 31, 2021 | Sep. 30, 2022 | Sep. 30, 2021
Common Stock |  |  |  |  |  |  |  |
Balance, beginning | $ 365,093 | $ 398,101 | $ 419,476 | $ 182,282 | $ 194,166 | $ 209,357 | $ 419,476 | $ 209,357
Balance (in shares) |  |  | 46,730,198 |  |  |  | 46,730,198 |
Shares issued under stock option and employee stock purchase plans | 2,306 | 71 | $ 304 | 2,004 |  | 74 |  |
Shares issued under stock option and employee stock purchase plans |  |  |  |  | (25) |  |  |
Shares issued in underwritten offering, net |  |  |  | 269,893 |  |  |  |
Stock-based compensation | 4,496 | 3,454 | 3,153 | 3,029 | 1,509 | 1,275 |  |
Unrealized gain (loss) on marketable securities | 305 | (529) | (1,782) | (44) | 5 | (2) | $ (2,006) | (41)
Net loss | (26,784) | (36,004) | (23,050) | (20,452) | (13,373) | (16,538) | (85,838) | (50,363)
Balance, ending | $ 345,416 | 365,093 | 398,101 | 436,712 | 182,282 | 194,166 | $ 345,416 | 436,712
Balance (in shares) | 47,096,063 |  |  |  |  |  | 47,096,063 |
Aggregate gross offering price available | $ 50,000 |  |  |  |  |  | $ 50,000 |
Common Stock |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Balance, beginning | $ 47 | $ 47 | $ 47 | $ 40 | $ 40 | $ 40 | $ 47 | $ 40
Balance (in shares) | 46,764,703 | 46,754,348 | 46,730,198 | 39,616,696 | 39,614,638 | 39,603,771 | 46,730,198 | 39,603,771
Shares issued under stock option and employee stock purchase plans (in shares) | 331,360 | 10,355 | 24,150 | 201,406 | 2,058 | 10,867 |  |
Shares issued in underwritten offering, net |  |  |  | $ 7 |  |  |  |
Shares issued in underwritten offering, net (in shares) |  |  |  | 6,845,238 |  |  |  |
Balance, ending | $ 47 | $ 47 | $ 47 | $ 47 | $ 40 | $ 40 | $ 47 | $ 47
Balance (in shares) | 47,096,063 | 46,764,703 | 46,754,348 | 46,663,340 | 39,616,696 | 39,614,638 | 47,096,063 | 46,663,340
Additional Paid-In Capital |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Balance, beginning | $ 1,568,124 | $ 1,564,599 | $ 1,561,142 | $ 1,282,657 | $ 1,281,173 | $ 1,279,824 | $ 1,561,142 | $ 1,279,824
Shares issued under stock option and employee stock purchase plans | 2,306 | 71 | 304 | 2,004 |  | 74 |  |
Shares issued under stock option and employee stock purchase plans |  |  |  |  | (25) |  |  |
Shares issued in underwritten offering, net |  |  |  | 269,886 |  |  |  |
Stock-based compensation | 4,496 | 3,454 | 3,153 | 3,029 | 1,509 | 1,275 |  |
Balance, ending | 1,574,926 | 1,568,124 | 1,564,599 | 1,557,576 | 1,282,657 | 1,281,173 | 1,574,926 | 1,557,576
Accumulated Other Comprehensive Income. |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Balance, beginning | (417) | 112 | 1,894 | 2,592 | 2,587 | 2,589 | 1,894 | 2,589
Unrealized gain (loss) on marketable securities | 305 | (529) | (1,782) | (44) | 5 | (2) |  |
Balance, ending | (112) | (417) | 112 | 2,548 | 2,592 | 2,587 | (112) | 2,548
Accumulated Deficit |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Balance, beginning | (1,202,661) | (1,166,657) | (1,143,607) | (1,103,007) | (1,089,634) | (1,073,096) | (1,143,607) | (1,073,096)
Net loss | (26,784) | (36,004) | (23,050) | (20,452) | (13,373) | (16,538) |  |
Balance, ending | $ (1,229,445) | $ (1,202,661) | $ (1,166,657) | $ (1,123,459) | $ (1,103,007) | $ (1,089,634) | $ (1,229,445) | $ (1,123,459)

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