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Stockholders' Equity | 9 Months Ended
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Sep. 30, 2022
Stockholders' Equity |
Stockholders' Equity | (7) Stockholders’ Equity ​ In May 2016, the Company entered into a controlled equity offering sales agreement (the “Cantor Agreement”) with Cantor Fitzgerald & Co. (“Cantor”) to allow the Company to issue and sell shares of its common stock from time to time through Cantor, acting as agent. At September 30, 2022, the Company had $50.0 million remaining in aggregate gross offering price available under the Company’s November 2020 prospectus. ​ The changes in Stockholders’ Equity during the three and nine months ended September 30, 2022 and 2021 are summarized below: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | ​ | ​ |  | ​ | ​ |  | Accumulated |  | ​ | ​ |  | ​ | ​
​ | ​ | Common | ​ | Common | ​ | Additional | ​ | Other | ​ | ​ | ​ | ​ | Total
​ | ​ | Stock | ​ | Stock Par | ​ | Paid-In | ​ | Comprehensive | ​ | Accumulated | ​ | Stockholders’
​ |  | Shares |  | Value |  | Capital |  | Income |  | Deficit |  | Equity
Consolidated balance at December 31, 2021 |  | 46,730,198 |  | $ | 47 |  | $ | 1,561,142 |  | $ | 1,894 |  | $ | (1,143,607) |  | $ | 419,476
Shares issued under stock option and employee stock purchase plans |  | 24,150 |  |  | — |  |  | 304 |  |  | — |  |  | — |  |  | 304
Stock-based compensation |  | — |  |  | — |  |  | 3,153 |  |  | — |  |  | — |  |  | 3,153
Unrealized loss on marketable securities |  | — |  |  | — |  |  | — |  |  | (1,782) |  |  | — |  |  | (1,782)
Net loss |  | — |  |  | — |  |  | — |  |  | — |  |  | (23,050) |  |  | (23,050)
Consolidated balance at March 31, 2022 |  | 46,754,348 |  | $ | 47 |  | $ | 1,564,599 |  | $ | 112 |  | $ | (1,166,657) |  | $ | 398,101
Shares issued under stock option and employee stock purchase plans | ​ | 10,355 | ​ | ​ | — | ​ | ​ | 71 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 71
Stock-based compensation | ​ | — | ​ | ​ | — | ​ | ​ | 3,454 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 3,454
Unrealized loss on marketable securities | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (529) | ​ | ​ | — | ​ | ​ | (529)
Net loss | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (36,004) | ​ | ​ | (36,004)
Consolidated balance at June 30, 2022 | ​ | 46,764,703 | ​ | $ | 47 | ​ | $ | 1,568,124 | ​ | $ | (417) | ​ | $ | (1,202,661) | ​ | $ | 365,093
Shares issued under stock option and employee stock purchase plans | ​ | 331,360 | ​ | ​ | — | ​ | ​ | 2,306 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 2,306
Stock-based compensation | ​ | — | ​ | ​ | — | ​ | ​ | 4,496 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 4,496
Unrealized gain on marketable securities | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 305 | ​ | ​ | — | ​ | ​ | 305
Net loss | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (26,784) | ​ | ​ | (26,784)
Consolidated balance at September 30, 2022 | ​ | 47,096,063 | ​ | $ | 47 | ​ | $ | 1,574,926 | ​ | $ | (112) | ​ | $ | (1,229,445) | ​ | $ | 345,416
​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | ​ | ​ |  | ​ | ​ |  | Accumulated |  | ​ | ​ |  | ​ | ​
​ | ​ | Common | ​ | Common | ​ | Additional | ​ | Other | ​ | ​ | ​ | ​ | Total
​ | ​ | Stock | ​ | Stock Par | ​ | Paid-In | ​ | Comprehensive | ​ | Accumulated | ​ | Stockholders’
​ | ​ | Shares | ​ | Value | ​ | Capital | ​ | Income | ​ | Deficit | ​ | Equity
​ | ​ | (In thousands, except share amounts)
Consolidated balance at December 31, 2020 |  | 39,603,771 | ​ | $ | 40 | ​ | $ | 1,279,824 | ​ | $ | 2,589 | ​ | $ | (1,073,096) | ​ | $ | 209,357
Shares issued under stock option and employee stock purchase plans |  | 10,867 | ​ |  | — | ​ |  | 74 | ​ |  | — | ​ |  | — | ​ |  | 74
Stock-based compensation |  | — | ​ |  | — | ​ |  | 1,275 | ​ |  | — | ​ |  | — | ​ |  | 1,275
Unrealized loss on marketable securities |  | — | ​ |  | — | ​ |  | — | ​ |  | (2) | ​ |  | — | ​ |  | (2)
Net loss |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | (16,538) | ​ |  | (16,538)
Consolidated balance at March 31, 2021 |  | 39,614,638 | ​ | $ | 40 | ​ | $ | 1,281,173 | ​ | $ | 2,587 | ​ | $ | (1,089,634) | ​ | $ | 194,166
Shares issued under stock option and employee stock purchase plans |  | 2,058 | ​ |  | — | ​ |  | (25) | ​ |  | — | ​ |  | — | ​ |  | (25)
Stock-based compensation |  | — | ​ |  | — | ​ |  | 1,509 | ​ |  | — | ​ |  | — | ​ |  | 1,509
Unrealized gain on marketable securities |  | — | ​ |  | — | ​ |  | — | ​ |  | 5 | ​ |  | — | ​ |  | 5
Net loss |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | (13,373) | ​ |  | (13,373)
Consolidated balance at June 30, 2021 |  | 39,616,696 | ​ | $ | 40 | ​ | $ | 1,282,657 | ​ | $ | 2,592 | ​ | $ | (1,103,007) | ​ | $ | 182,282
Shares issued under stock option and employee stock purchase plans | ​ | 201,406 | ​ | ​ | — | ​ | ​ | 2,004 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 2,004
Shares issued in underwritten offering, net | ​ | 6,845,238 | ​ | ​ | 7 | ​ | ​ | 269,886 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 269,893
Stock-based compensation | ​ | — | ​ | ​ | — | ​ | ​ | 3,029 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 3,029
Unrealized loss on marketable securities | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (44) | ​ | ​ | — | ​ | ​ | (44)
Net loss | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (20,452) | ​ | ​ | (20,452)
Consolidated balance at September 30, 2021 | ​ | 46,663,340 | ​ | $ | 47 | ​ | $ | 1,557,576 | ​ | $ | 2,548 | ​ | $ | (1,123,459) | ​ | $ | 436,712
​

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