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Stockholders' Equity (Tables) | 9 Months Ended
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Sep. 30, 2022
Stockholders' Equity |
Schedule of Shareholder's equity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | ​ | ​ |  | ​ | ​ |  | Accumulated |  | ​ | ​ |  | ​ | ​
​ | ​ | Common | ​ | Common | ​ | Additional | ​ | Other | ​ | ​ | ​ | ​ | Total
​ | ​ | Stock | ​ | Stock Par | ​ | Paid-In | ​ | Comprehensive | ​ | Accumulated | ​ | Stockholders’
​ |  | Shares |  | Value |  | Capital |  | Income |  | Deficit |  | Equity
Consolidated balance at December 31, 2021 |  | 46,730,198 |  | $ | 47 |  | $ | 1,561,142 |  | $ | 1,894 |  | $ | (1,143,607) |  | $ | 419,476
Shares issued under stock option and employee stock purchase plans |  | 24,150 |  |  | — |  |  | 304 |  |  | — |  |  | — |  |  | 304
Stock-based compensation |  | — |  |  | — |  |  | 3,153 |  |  | — |  |  | — |  |  | 3,153
Unrealized loss on marketable securities |  | — |  |  | — |  |  | — |  |  | (1,782) |  |  | — |  |  | (1,782)
Net loss |  | — |  |  | — |  |  | — |  |  | — |  |  | (23,050) |  |  | (23,050)
Consolidated balance at March 31, 2022 |  | 46,754,348 |  | $ | 47 |  | $ | 1,564,599 |  | $ | 112 |  | $ | (1,166,657) |  | $ | 398,101
Shares issued under stock option and employee stock purchase plans | ​ | 10,355 | ​ | ​ | — | ​ | ​ | 71 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 71
Stock-based compensation | ​ | — | ​ | ​ | — | ​ | ​ | 3,454 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 3,454
Unrealized loss on marketable securities | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (529) | ​ | ​ | — | ​ | ​ | (529)
Net loss | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (36,004) | ​ | ​ | (36,004)
Consolidated balance at June 30, 2022 | ​ | 46,764,703 | ​ | $ | 47 | ​ | $ | 1,568,124 | ​ | $ | (417) | ​ | $ | (1,202,661) | ​ | $ | 365,093
Shares issued under stock option and employee stock purchase plans | ​ | 331,360 | ​ | ​ | — | ​ | ​ | 2,306 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 2,306
Stock-based compensation | ​ | — | ​ | ​ | — | ​ | ​ | 4,496 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 4,496
Unrealized gain on marketable securities | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 305 | ​ | ​ | — | ​ | ​ | 305
Net loss | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (26,784) | ​ | ​ | (26,784)
Consolidated balance at September 30, 2022 | ​ | 47,096,063 | ​ | $ | 47 | ​ | $ | 1,574,926 | ​ | $ | (112) | ​ | $ | (1,229,445) | ​ | $ | 345,416
​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | ​ | ​ |  | ​ | ​ |  | Accumulated |  | ​ | ​ |  | ​ | ​
​ | ​ | Common | ​ | Common | ​ | Additional | ​ | Other | ​ | ​ | ​ | ​ | Total
​ | ​ | Stock | ​ | Stock Par | ​ | Paid-In | ​ | Comprehensive | ​ | Accumulated | ​ | Stockholders’
​ | ​ | Shares | ​ | Value | ​ | Capital | ​ | Income | ​ | Deficit | ​ | Equity
​ | ​ | (In thousands, except share amounts)
Consolidated balance at December 31, 2020 |  | 39,603,771 | ​ | $ | 40 | ​ | $ | 1,279,824 | ​ | $ | 2,589 | ​ | $ | (1,073,096) | ​ | $ | 209,357
Shares issued under stock option and employee stock purchase plans |  | 10,867 | ​ |  | — | ​ |  | 74 | ​ |  | — | ​ |  | — | ​ |  | 74
Stock-based compensation |  | — | ​ |  | — | ​ |  | 1,275 | ​ |  | — | ​ |  | — | ​ |  | 1,275
Unrealized loss on marketable securities |  | — | ​ |  | — | ​ |  | — | ​ |  | (2) | ​ |  | — | ​ |  | (2)
Net loss |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | (16,538) | ​ |  | (16,538)
Consolidated balance at March 31, 2021 |  | 39,614,638 | ​ | $ | 40 | ​ | $ | 1,281,173 | ​ | $ | 2,587 | ​ | $ | (1,089,634) | ​ | $ | 194,166
Shares issued under stock option and employee stock purchase plans |  | 2,058 | ​ |  | — | ​ |  | (25) | ​ |  | — | ​ |  | — | ​ |  | (25)
Stock-based compensation |  | — | ​ |  | — | ​ |  | 1,509 | ​ |  | — | ​ |  | — | ​ |  | 1,509
Unrealized gain on marketable securities |  | — | ​ |  | — | ​ |  | — | ​ |  | 5 | ​ |  | — | ​ |  | 5
Net loss |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | (13,373) | ​ |  | (13,373)
Consolidated balance at June 30, 2021 |  | 39,616,696 | ​ | $ | 40 | ​ | $ | 1,282,657 | ​ | $ | 2,592 | ​ | $ | (1,103,007) | ​ | $ | 182,282
Shares issued under stock option and employee stock purchase plans | ​ | 201,406 | ​ | ​ | — | ​ | ​ | 2,004 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 2,004
Shares issued in underwritten offering, net | ​ | 6,845,238 | ​ | ​ | 7 | ​ | ​ | 269,886 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 269,893
Stock-based compensation | ​ | — | ​ | ​ | — | ​ | ​ | 3,029 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 3,029
Unrealized loss on marketable securities | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (44) | ​ | ​ | — | ​ | ​ | (44)
Net loss | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (20,452) | ​ | ​ | (20,452)
Consolidated balance at September 30, 2021 | ​ | 46,663,340 | ​ | $ | 47 | ​ | $ | 1,557,576 | ​ | $ | 2,548 | ​ | $ | (1,123,459) | ​ | $ | 436,712

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- Definition Tabular disclosure of changes in the separate accounts comprising stockholders' equity (in addition to retained earnings) and of the changes in the number of shares of equity securities during at least the most recent annual fiscal period and any subsequent interim period presented is required to make the financial statements sufficiently informative if both financial position and results of operations are presented. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=126973232&loc=d3e21463-112644 + Details
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