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Income Taxes - Summary of deferred tax assets and liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
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Gross deferred tax assets |  |
Net operating loss carryforwards | $ 188,255 | $ 183,711
Tax credit carryforwards | 50,688 | 47,927
Deferred research and development expenses | 67,494 | 59,753
Stock-based compensation | 9,993 | 14,719
Fixed assets | 1,193 | 1,287
Accrued expenses and other | 373 | 370
Deferred tax assets, gross | 317,996 | 307,767
Gross deferred tax liabilities |  |
IPR&D intangibles | (6,840) | (6,840)
Total deferred tax assets and liabilities | 311,156 | 300,927
Valuation allowance | (312,769) | (302,540)
Net deferred tax liability | $ (1,613) | $ (1,613)

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