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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2022
Stock-Based Compensation |
Schedule of stock option activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | Weighted |  | Weighted
​ | ​ | ​ | ​ | Average | ​ | Average
​ | ​ | ​ | ​ | Exercise | ​ | Remaining
​ | ​ | ​ | ​ | Price | ​ | Contractual
​ | ​ | Shares | ​ | Per Share | ​ | Term (In Years)
Options outstanding at December 31, 2021 | ​ | 4,077,667 | ​ | $ | 30.02 | ​ | 8.0
Granted | ​ | 1,620,000 | ​ | $ | 23.19 | ​ | —
Exercised | ​ | (458,254) | ​ | $ | 8.22 | ​ | —
Canceled | ​ | (153,751) | ​ | $ | 48.36 | ​ | —
Options outstanding at December 31, 2022 | ​ | 5,085,662 | ​ | $ | 29.26 | ​ | 7.9
Options vested and expected to vest at December 31, 2022 | ​ | 4,970,769 | ​ | $ | 29.40 | ​ | 7.8
Options exercisable at December 31, 2022 | ​ | 2,100,491 | ​ | $ | 40.05 | ​ | 6.6
Shares available for grant under the 2021 Plan | ​ | 1,837,968 | ​ | ​ | — | ​ | —
​
Schedule of stock-based compensation expense | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2022 |  | 2021 |  | 2020
​ | ​ | (In thousands)
Research and development | ​ | $ | 8,082 | ​ | $ | 4,525 | ​ | $ | 1,933
General and administrative | ​ | ​ | 7,529 | ​ | ​ | 4,428 | ​ | ​ | 1,982
Total stock-based compensation expense | ​ | $ | 15,611 | ​ | $ | 8,953 | ​ | $ | 3,915
​
Schedule of assumptions used for the fair value of employee stock options granted | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2022 |  | 2021 |  | 2020
Expected stock price volatility | ​ | 90 - 97% | ​ | 97 - 98% | ​ | 91 - 98%
Expected option term | ​ | 6.0 Years | ​ | 6.0 Years | ​ | 6.0 Years
Risk-free interest rate | ​ | 1.7 - 4.2% | ​ | 0.8 - 1.4% | ​ | 0.5 - 0.7%
Expected dividend yield | ​ | None | ​ | None | ​ | None
​

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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