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Nature of Business and Overview (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Nature of Business and Overview |  |  |
Cash, cash equivalents and marketable securities | $ 305,000 |  |
Net loss | (112,325) | $ (70,511) | $ (59,780)
Net cash used in operations | $ (103,732) | $ (60,909) | $ (40,404)

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