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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Revenues: |  |  |
Total revenues | $ 2,357 | $ 4,651 | $ 7,418
Operating expenses: |  |  |
Research and development | 82,258 | 53,311 | 42,534
General and administrative | 27,195 | 20,488 | 14,456
Intangible asset impairment |  | 3,500 | 18,000
Gain on fair value remeasurement of contingent consideration | (6,862) | (1,405) | (4,218)
Litigation settlement related loss | 15,000 |  |
Total operating expenses | 117,591 | 75,894 | 70,772
Operating loss | (115,234) | (71,243) | (63,354)
Investment and other income, net | 2,909 | 505 | 2,407
Net loss before income tax benefit | (112,325) | (70,738) | (60,947)
Income tax benefit |  | 227 | 1,167
Net loss | $ (112,325) | $ (70,511) | $ (59,780)
Basic and diluted net loss per common share | $ (2.40) | $ (1.64) | $ (2.02)
Basic and diluted net loss per common share | $ (2.40) | $ (1.64) | $ (2.02)
Shares used in calculating basic and diluted net loss per share | 46,888 | 42,870 | 29,640
Shares used in calculating basic and diluted net loss per share | 46,888 | 42,870 | 29,640
Comprehensive loss: |  |  |
Net loss | $ (112,325) | $ (70,511) | $ (59,780)
Other comprehensive income (loss): |  |  |
Unrealized loss on marketable securities | (634) | (695) | (30)
Comprehensive loss | (112,959) | (71,206) | (59,810)
Product development and licensing agreements |  |  |
Revenues: |  |  |
Total revenues | 56 | 31 | 2,301
Contracts and grants |  |  |
Revenues: |  |  |
Total revenues | $ 2,301 | $ 4,620 | $ 5,117

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