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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |  |
Net loss | $ (112,325) | $ (70,511) | $ (59,780)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 2,896 | 3,068 | 3,929
Amortization and premium of marketable securities, net | 844 | (3,209) | (729)
Loss (gain) on sale or disposal of assets | 2 | (24) | (55)
Intangible asset impairment |  | 3,500 | 18,000
Gain on fair value remeasurement of contingent consideration | (6,862) | (1,405) | (4,218)
Non-cash income tax benefit |  | (227) | (1,167)
Stock-based compensation expense | 15,611 | 8,953 | 3,915
Changes in operating assets and liabilities: |  |  |
Accounts and other receivables | (175) | 1,574 | (787)
Prepaid and other current assets | (9,572) | (1,871) | (334)
Other assets |  | (5) |
Accounts payable and accrued expenses | 3,123 | 3,653 | 1,638
Other liabilities | 2,726 | (4,405) | (816)
Net cash used in operating activities | (103,732) | (60,909) | (40,404)
Cash flows from investing activities: |  |  |
Sales and maturities of marketable securities | 280,666 | 174,947 | 123,600
Purchases of marketable securities | (188,965) | (389,881) | (220,321)
Acquisition of property and equipment | (1,828) | (1,249) | (1,552)
Proceeds from sale or disposal of assets | 69 | 27 | 55
Net cash provided by (used in) investing activities | 89,942 | (216,156) | (98,218)
Cash flows from financing activities: |  |  |
Net proceeds from stock issuances |  | 269,893 | 170,792
Proceeds from issuance of stock from employee benefit plans | 4,076 | 2,479 | 434
Issuance of term loan |  |  | 2,962
Payment of term loan |  |  | (2,962)
Net cash provided by financing activities | 4,076 | 272,372 | 171,226
Net (decrease) increase in cash and cash equivalents | (9,714) | (4,693) | 32,604
Cash and cash equivalents at beginning of period | 39,143 | 43,836 | 11,232
Cash and cash equivalents at end of period | 29,429 | 39,143 | 43,836
Non-cash investing activities |  |  |
Accrued construction in progress | $ 113 | $ 289 | $ 221

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- Definition The cash inflow from the sale of property, plant and equipment (capital expenditures), software, and other intangible assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3255-108585 + Details
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- Definition The cash outflow during the period from the repayment of aggregate short-term and long-term debt. Excludes payment of capital lease obligations. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3291-108585 + Details
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