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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Cash flows from operating activities: |  |  |
Net loss | $ (141,429) | $ (112,325) | $ (70,511)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 3,008 | 2,896 | 3,068
Amortization and premium of marketable securities, net | (6,222) | 844 | (3,209)
Loss (gain) on sale or disposal of assets |  | 2 | (24)
Intangible asset impairment |  |  | 3,500
Gain on fair value remeasurement of contingent consideration |  | (6,862) | (1,405)
Non-cash income tax benefit |  |  | (227)
Stock-based compensation expense | 23,890 | 15,611 | 8,953
Changes in operating assets and liabilities: |  |  |
Accounts and other receivables | (2,281) | (175) | 1,574
Prepaid and other current assets | 5,900 | (9,572) | (1,871)
Other assets | (3) |  | (5)
Accounts payable and accrued expenses | 9,384 | 3,123 | 3,653
Other liabilities | 462 | 2,726 | (4,405)
Net cash used in operating activities | (107,291) | (103,732) | (60,909)
Cash flows from investing activities: |  |  |
Sales and maturities of marketable securities | 320,597 | 280,666 | 174,947
Purchases of marketable securities | (424,561) | (188,965) | (389,881)
Acquisition of property and equipment | (1,818) | (1,828) | (1,249)
Proceeds from sale or disposal of assets |  | 69 | 27
Net cash (used in) provided by investing activities | (105,782) | 89,942 | (216,156)
Cash flows from financing activities: |  |  |
Net proceeds from stock issuances | 216,222 |  | 269,893
Proceeds from issuance of stock from employee benefit plans | 2,236 | 4,076 | 2,479
Net cash provided by financing activities | 218,458 | 4,076 | 272,372
Net increase (decrease) in cash and cash equivalents | 5,385 | (9,714) | (4,693)
Cash and cash equivalents at beginning of period | 29,429 | 39,143 | 43,836
Cash and cash equivalents at end of period | 34,814 | 29,429 | 39,143
Non-cash investing activities |  |  |
Accrued construction in progress | $ 77 | $ 113 | $ 289

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- Definition The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 28 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-28 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 28 -Subparagraph (a) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-28 + Details
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