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Stockholders' Equity (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2024 | Mar. 31, 2024 | Jun. 30, 2023 | Mar. 31, 2023 | Jun. 30, 2024 | Jun. 30, 2023
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Balance, beginning | $ 838,613 | $ 429,171 | $ 302,740 | $ 326,204 | $ 429,171 | $ 326,204
Balance, beginning (in shares) |  | 55,883,377 |  |  | 55,883,377 |
Shares issued under stock option and employee stock purchase plans | 3,712 | $ 3,814 | 133 | 694 |  |
Shares issued in underwritten offering, net |  | 432,298 |  |  |  |
Stock-based compensation | 7,640 | 7,202 | 5,217 | 4,340 |  |
Unrealized loss on marketable securities | (464) | (1,064) | (51) | 863 | $ (1,528) | 812
Net loss | (35,842) | (32,808) | (30,502) | (29,361) | (68,650) | (59,863)
Balance, ending | $ 813,659 | 838,613 | 277,537 | 302,740 | $ 813,659 | 277,537
Balance, ending (in shares) | 66,280,667 |  |  |  | 66,280,667 |
Common Stock |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Balance, beginning | $ 66 | $ 56 | $ 47 | $ 47 | $ 56 | $ 47
Balance, beginning (in shares) | 65,910,548 | 55,883,377 | 47,244,681 | 47,200,695 | 55,883,377 | 47,200,695
Shares issued under stock option and employee stock purchase plans (in shares) | 370,119 | 229,171 | 9,132 | 43,986 |  |
Shares issued in underwritten offering, net |  | $ 10 |  |  |  |
Shares issued in underwritten offering, net (in shares) |  | 9,798,000 |  |  |  |
Balance, ending | $ 66 | $ 66 | $ 47 | $ 47 | $ 66 | $ 47
Balance, ending (in shares) | 66,280,667 | 65,910,548 | 47,253,813 | 47,244,681 | 66,280,667 | 47,253,813
Additional Paid-In Capital |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Balance, beginning | $ 2,266,472 | $ 1,823,168 | $ 1,585,863 | $ 1,580,829 | $ 1,823,168 | $ 1,580,829
Shares issued under stock option and employee stock purchase plans | 3,712 | 3,814 | 133 | 694 |  |
Shares issued in underwritten offering, net |  | 432,288 |  |  |  |
Stock-based compensation | 7,640 | 7,202 | 5,217 | 4,340 |  |
Balance, ending | 2,277,824 | 2,266,472 | 1,591,213 | 1,585,863 | 2,277,824 | 1,591,213
Accumulated Other Comprehensive Income |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Balance, beginning | 2,244 | 3,308 | 2,123 | 1,260 | 3,308 | 1,260
Unrealized loss on marketable securities | (464) | (1,064) | (51) | 863 |  |
Balance, ending | 1,780 | 2,244 | 2,072 | 2,123 | 1,780 | 2,072
Accumulated Deficit |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Balance, beginning | (1,430,169) | (1,397,361) | (1,285,293) | (1,255,932) | (1,397,361) | (1,255,932)
Net loss | (35,842) | (32,808) | (30,502) | (29,361) |  |
Balance, ending | $ (1,466,011) | $ (1,430,169) | $ (1,315,795) | $ (1,285,293) | $ (1,466,011) | $ (1,315,795)

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