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Stockholders' Equity (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2024
Mar. 31, 2024
Jun. 30, 2023
Mar. 31, 2023
Jun. 30, 2024
Jun. 30, 2023
Increase (Decrease) in Stockholders' Equity            
Balance, beginning $ 838,613 $ 429,171 $ 302,740 $ 326,204 $ 429,171 $ 326,204
Balance, beginning (in shares)   55,883,377     55,883,377  
Shares issued under stock option and employee stock purchase plans 3,712 $ 3,814 133 694    
Shares issued in underwritten offering, net   432,298        
Stock-based compensation 7,640 7,202 5,217 4,340    
Unrealized loss on marketable securities (464) (1,064) (51) 863 $ (1,528) 812
Net loss (35,842) (32,808) (30,502) (29,361) (68,650) (59,863)
Balance, ending $ 813,659 838,613 277,537 302,740 $ 813,659 277,537
Balance, ending (in shares) 66,280,667       66,280,667  
Common Stock            
Increase (Decrease) in Stockholders' Equity            
Balance, beginning $ 66 $ 56 $ 47 $ 47 $ 56 $ 47
Balance, beginning (in shares) 65,910,548 55,883,377 47,244,681 47,200,695 55,883,377 47,200,695
Shares issued under stock option and employee stock purchase plans (in shares) 370,119 229,171 9,132 43,986    
Shares issued in underwritten offering, net   $ 10        
Shares issued in underwritten offering, net (in shares)   9,798,000        
Balance, ending $ 66 $ 66 $ 47 $ 47 $ 66 $ 47
Balance, ending (in shares) 66,280,667 65,910,548 47,253,813 47,244,681 66,280,667 47,253,813
Additional Paid-In Capital            
Increase (Decrease) in Stockholders' Equity            
Balance, beginning $ 2,266,472 $ 1,823,168 $ 1,585,863 $ 1,580,829 $ 1,823,168 $ 1,580,829
Shares issued under stock option and employee stock purchase plans 3,712 3,814 133 694    
Shares issued in underwritten offering, net   432,288        
Stock-based compensation 7,640 7,202 5,217 4,340    
Balance, ending 2,277,824 2,266,472 1,591,213 1,585,863 2,277,824 1,591,213
Accumulated Other Comprehensive Income            
Increase (Decrease) in Stockholders' Equity            
Balance, beginning 2,244 3,308 2,123 1,260 3,308 1,260
Unrealized loss on marketable securities (464) (1,064) (51) 863    
Balance, ending 1,780 2,244 2,072 2,123 1,780 2,072
Accumulated Deficit            
Increase (Decrease) in Stockholders' Equity            
Balance, beginning (1,430,169) (1,397,361) (1,285,293) (1,255,932) (1,397,361) (1,255,932)
Net loss (35,842) (32,808) (30,502) (29,361)    
Balance, ending $ (1,466,011) $ (1,430,169) $ (1,315,795) $ (1,285,293) $ (1,466,011) $ (1,315,795)