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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2024
Income Taxes |
Schedule of components of income tax benefit (provision) | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended December 31,
​ |  | 2024 |  | 2023 |  | 2022
​ | ​ | (In thousands)
Income tax benefit (provision): | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Federal | ​ | $ | 39,821 | ​ | $ | 36,067 | ​ | $ | 17,484
State | ​ | ​ | 15,375 | ​ | ​ | 13,691 | ​ | ​ | 9,606
Expiration of NOLs and R&D credit | ​ | ​ | (82,825) | ​ | ​ | (15,141) | ​ | ​ | (16,862)
​ | ​ | ​ | (27,629) | ​ | ​ | 34,617 | ​ | ​ | 10,228
Deferred tax valuation allowance | ​ | ​ | 27,629 | ​ | ​ | (34,617) | ​ | ​ | (10,228)
​ | ​ | $ | — | ​ | $ | — | ​ | $ | —
​
Schedule of reconciliation between the amount of reported income tax and the amount computed using the U.S. Statutory rate | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2024 |  | 2023 |  | 2022
​ | ​ | (In thousands)
Pre-tax loss | ​ | $ | (157,863) | ​ | $ | (141,429) | ​ | $ | (112,325)
Loss at statutory rates | ​ | ​ | (33,151) | ​ | ​ | (29,700) | ​ | ​ | (23,588)
Research and development credits | ​ | ​ | (7,332) | ​ | ​ | (5,237) | ​ | ​ | (3,876)
State taxes | ​ | ​ | (15,375) | ​ | ​ | (13,691) | ​ | ​ | (9,606)
Other | ​ | ​ | 662 | ​ | ​ | (1,130) | ​ | ​ | 11,421
Change in fair value remeasurement of contingent consideration | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (1,441)
Expiration of Federal and State NOLs and R&D credits | ​ | ​ | 82,825 | ​ | ​ | 15,141 | ​ | ​ | 16,862
Change in valuation allowance | ​ | ​ | (27,629) | ​ | ​ | 34,617 | ​ | ​ | 10,228
Income tax (benefit) provision | ​ | $ | — | ​ | $ | — | ​ | $ | —
​
Schedule of principal components of the deferred tax assets and liabilities | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | December 31, |  | December 31,
​ | ​ | 2024 | ​ | 2023
​ | ​ | (In thousands)
Gross deferred tax assets | ​ | ​ | ​ | ​ | ​ | ​
Net operating loss carryforwards | ​ | $ | 176,816 | ​ | $ | 197,618
Tax credit carryforwards | ​ | ​ | 24,718 | ​ | ​ | 56,830
Deferred research and development expenses | ​ | ​ | 101,047 | ​ | ​ | 82,077
Stock-based compensation | ​ | ​ | 20,940 | ​ | ​ | 14,671
Fixed assets | ​ | ​ | 1,033 | ​ | ​ | 1,019
Accrued expenses and other | ​ | ​ | 429 | ​ | ​ | 398
​ | ​ | ​ | 324,983 | ​ | ​ | 352,613
Gross deferred tax liabilities | ​ | ​ | ​ | ​ | ​ | ​
IPR&D intangibles | ​ | ​ | (6,840) | ​ | ​ | (6,840)
Total deferred tax assets and liabilities | ​ | ​ | 318,143 | ​ | ​ | 345,773
Valuation allowance | ​ | ​ | (319,756) | ​ | ​ | (347,386)
Net deferred tax liability | ​ | $ | (1,613) | ​ | $ | (1,613)

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- Definition Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 9 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-9 + Details
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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-2 + Details
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