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Income Taxes - Summary of deferred tax assets and liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2024 | Dec. 31, 2023
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Gross deferred tax assets |  |
Net operating loss carryforwards | $ 176,816 | $ 197,618
Tax credit carryforwards | 24,718 | 56,830
Deferred research and development expenses | 101,047 | 82,077
Stock-based compensation | 20,940 | 14,671
Fixed assets | 1,033 | 1,019
Accrued expenses and other | 429 | 398
Deferred tax assets, gross | 324,983 | 352,613
Gross deferred tax liabilities |  |
IPR&D intangibles | (6,840) | (6,840)
Total deferred tax assets and liabilities | 318,143 | 345,773
Valuation allowance | (319,756) | (347,386)
Net deferred tax liability | $ (1,613) | $ (1,613)

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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-2 + Details
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