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Nature of Business and Overview (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Nature of Business and Overview |  |  |
Cash, cash equivalents and marketable securities | $ 725,300 |  |
Net loss | (157,863) | $ (141,429) | $ (112,325)
Net cash used in operations | $ (157,778) | $ (107,291) | $ (103,732)

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