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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Revenues: |  |  |
Total revenues | $ 7,020 | $ 6,883 | $ 2,357
Operating expenses: |  |  |
Research and development | 163,550 | 118,011 | 82,258
General and administrative | 38,548 | 30,914 | 27,195
Gain on fair value remeasurement of contingent consideration |  |  | (6,862)
Litigation settlement related loss |  | 12,500 | 15,000
Total operating expenses | 202,098 | 161,425 | 117,591
Operating loss | (195,078) | (154,542) | (115,234)
Investment and other income, net | 37,215 | 13,113 | 2,909
Net loss | $ (157,863) | $ (141,429) | $ (112,325)
Basic net loss per common share (in dollars per share) | $ (2.45) | $ (2.92) | $ (2.4)
Diluted net loss per common share (in dollars per share) | $ (2.45) | $ (2.92) | $ (2.4)
Shares used in calculating basic net loss per share (in shares) | 64,395 | 48,449 | 46,888
Shares used in calculating diluted net loss per share (in shares) | 64,395 | 48,449 | 46,888
Comprehensive loss: |  |  |
Net loss | $ (157,863) | $ (141,429) | $ (112,325)
Other comprehensive income (loss): |  |  |
Unrealized gain (loss) on marketable securities | 6 | 2,048 | (634)
Comprehensive loss | (157,857) | (139,381) | (112,959)
Product development and licensing agreements |  |  |
Revenues: |  |  |
Total revenues | 13 | 278 | 56
Contracts and grants |  |  |
Revenues: |  |  |
Total revenues | $ 7,007 | $ 6,605 | $ 2,301

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