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Stockholders' Equity (Tables) | 6 Months Ended
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Jun. 30, 2025
Stockholders' Equity |
Schedule of shareholder's equity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | ​ | ​ |  | ​ | ​ |  | Accumulated |  | ​ | ​ |  | ​ | ​
​ | ​ | Common | ​ | Common | ​ | Additional | ​ | Other | ​ | ​ | ​ | ​ | Total
​ | ​ | Stock | ​ | Stock Par | ​ | Paid-In | ​ | Comprehensive | ​ | Accumulated | ​ | Stockholders’
​ |  | Shares |  | Value |  | Capital |  | Income |  | Deficit |  | Equity
​ | ​ | (In thousands, except share amounts)
Consolidated balance at December 31, 2024 |  | 66,374,549 | ​ | $ | 66 | ​ | $ | 2,298,849 | ​ | $ | 3,314 | ​ | $ | (1,555,224) | ​ | $ | 747,005
Shares issued under stock option and employee stock purchase plans |  | 9,642 | ​ | ​ | — | ​ | ​ | 202 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 202
Stock-based compensation |  | — | ​ | ​ | — | ​ | ​ | 9,316 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 9,316
Unrealized gain on marketable securities |  | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 254 | ​ | ​ | — | ​ | ​ | 254
Net loss |  | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (53,796) | ​ | ​ | (53,796)
Consolidated balance at March 31, 2025 |  | 66,384,191 | ​ | $ | 66 | ​ | $ | 2,308,367 | ​ | $ | 3,568 | ​ | $ | (1,609,020) | ​ | $ | 702,981
Shares issued under stock option and employee stock purchase plans | ​ | 10,050 | ​ | ​ | — | ​ | ​ | 63 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 63
Stock-based compensation | ​ | — | ​ | ​ | — | ​ | ​ | 9,191 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 9,191
Unrealized loss on marketable securities | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (229) | ​ | ​ | — | ​ | ​ | (229)
Net loss | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (56,600) | ​ | ​ | (56,600)
Consolidated balance at June 30, 2025 | ​ | 66,394,241 | ​ | $ | 66 | ​ | $ | 2,317,621 | ​ | $ | 3,339 | ​ | $ | (1,665,620) | ​ | $ | 655,406
​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | ​ | ​ |  | ​ | ​ |  | Accumulated |  | ​ | ​ |  | ​ | ​
​ | ​ | Common | ​ | Common | ​ | Additional | ​ | Other | ​ | ​ | ​ | ​ | Total
​ | ​ | Stock | ​ | Stock Par | ​ | Paid-In | ​ | Comprehensive | ​ | Accumulated | ​ | Stockholders’
​ | ​ | Shares | ​ | Value | ​ | Capital | ​ | Income | ​ | Deficit | ​ | Equity
​ | ​ | (In thousands, except share amounts)
Consolidated balance at December 31, 2023 |  | 55,883,377 | ​ | $ | 56 | ​ | $ | 1,823,168 | ​ | $ | 3,308 | ​ | $ | (1,397,361) | ​ | $ | 429,171
Shares issued under stock option and employee stock purchase plans |  | 229,171 | ​ | ​ | — | ​ | ​ | 3,814 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 3,814
Shares issued in underwritten offering, net |  | 9,798,000 | ​ | ​ | 10 | ​ | ​ | 432,288 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 432,298
Stock-based compensation |  | — | ​ | ​ | — | ​ | ​ | 7,202 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 7,202
Unrealized loss on marketable securities |  | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (1,064) | ​ | ​ | — | ​ | ​ | (1,064)
Net loss |  | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (32,808) | ​ | ​ | (32,808)
Consolidated balance at March 31, 2024 |  | 65,910,548 | ​ | $ | 66 | ​ | $ | 2,266,472 | ​ | $ | 2,244 | ​ | $ | (1,430,169) | ​ | $ | 838,613
Shares issued under stock option and employee stock purchase plans |  | 370,119 | ​ |  | — | ​ |  | 3,712 | ​ |  | — | ​ |  | — | ​ |  | 3,712
Stock-based compensation |  | — | ​ |  | — | ​ |  | 7,640 | ​ |  | — | ​ |  | — | ​ |  | 7,640
Unrealized loss on marketable securities |  | — | ​ |  | — | ​ |  | — | ​ |  | (464) | ​ |  | — | ​ |  | (464)
Net loss |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | (35,842) | ​ |  | (35,842)
Consolidated balance at June 30, 2024 |  | 66,280,667 | ​ | $ | 66 | ​ | $ | 2,277,824 | ​ | $ | 1,780 | ​ | $ | (1,466,011) | ​ | $ | 813,659
​

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- Definition Tabular disclosure of changes in the separate accounts comprising stockholders' equity (in addition to retained earnings) and of the changes in the number of shares of equity securities during at least the most recent annual fiscal period and any subsequent interim period presented is required to make the financial statements sufficiently informative if both financial position and results of operations are presented. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -SubTopic 10 -Topic 505 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481112/505-10-50-2 + Details
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