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Stockholders' Equity (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2024
Mar. 31, 2024
Jun. 30, 2025
Jun. 30, 2024
Increase (Decrease) in Stockholders' Equity            
Balance, beginning $ 702,981 $ 747,005 $ 838,613 $ 429,171 $ 747,005 $ 429,171
Balance, beginning (in shares)   66,374,549     66,374,549  
Shares issued under stock option and employee stock purchase plans 63 $ 202 3,712 3,814    
Shares issued in underwritten offering, net       432,298    
Stock-based compensation 9,191 9,316 7,640 7,202    
Unrealized gain (loss) on marketable securities (229) 254 (464) (1,064) $ 25 (1,528)
Net Income (Loss) (56,600) (53,796) (35,842) (32,808) (110,396) (68,650)
Balance, ending $ 655,406 702,981 813,659 838,613 $ 655,406 813,659
Balance, ending (in shares) 66,394,241       66,394,241  
Common Stock            
Increase (Decrease) in Stockholders' Equity            
Balance, beginning $ 66 $ 66 $ 66 $ 56 $ 66 $ 56
Balance, beginning (in shares) 66,384,191 66,374,549 65,910,548 55,883,377 66,374,549 55,883,377
Shares issued under stock option and employee stock purchase plans (in shares) 10,050 9,642 370,119 229,171    
Shares issued in underwritten offering, net       $ 10    
Shares issued in underwritten offering, net (in shares)       9,798,000    
Balance, ending $ 66 $ 66 $ 66 $ 66 $ 66 $ 66
Balance, ending (in shares) 66,394,241 66,384,191 66,280,667 65,910,548 66,394,241 66,280,667
Additional Paid-In Capital            
Increase (Decrease) in Stockholders' Equity            
Balance, beginning $ 2,308,367 $ 2,298,849 $ 2,266,472 $ 1,823,168 $ 2,298,849 $ 1,823,168
Shares issued under stock option and employee stock purchase plans 63 202 3,712 3,814    
Shares issued in underwritten offering, net       432,288    
Stock-based compensation 9,191 9,316 7,640 7,202    
Balance, ending 2,317,621 2,308,367 2,277,824 2,266,472 2,317,621 2,277,824
Accumulated Other Comprehensive Income            
Increase (Decrease) in Stockholders' Equity            
Balance, beginning 3,568 3,314 2,244 3,308 3,314 3,308
Unrealized gain (loss) on marketable securities (229) 254 (464) (1,064)    
Balance, ending 3,339 3,568 1,780 2,244 3,339 1,780
Accumulated Deficit            
Increase (Decrease) in Stockholders' Equity            
Balance, beginning (1,609,020) (1,555,224) (1,430,169) (1,397,361) (1,555,224) (1,397,361)
Net Income (Loss) (56,600) (53,796) (35,842) (32,808)    
Balance, ending $ (1,665,620) $ (1,609,020) $ (1,466,011) $ (1,430,169) $ (1,665,620) $ (1,466,011)