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Segment Information

6 Months Ended

Jun. 30, 2025

Segment Information

Segment Information

(3) Segment Information

The Company is managed as a single operating and reportable segment that operates in the business of development, manufacturing and commercialization of novel therapeutics for human health care. Our chief operating decision maker (“CODM”), the Chief Executive Officer, evaluates performance based on consolidated net loss. Other than general and administrative expenses as presented on the consolidated statement of operations, research and development expense disaggregated by program and by nature are considered to be the Company’s significant segment expenses. These results are used, in part, by our CODM in evaluating the performance of the Company by comparing budget to actual results, and to allocate resources. All revenue is derived in and long-lived assets are located in the United States. The CODM does not receive asset information other than what is presented on the consolidated balance sheets.

The following table is a summary of the Company’s research and development expenses disaggregated by program. The amounts disclosed reflect direct research and development costs and an allocation of indirect research and development costs to each program.

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Three Months Ended

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Three Months Ended

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Six Months Ended

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Six Months Ended

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June 30, 2025

June 30, 2024

June 30, 2025

June 30, 2024

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(In thousands)

Barzolvolimab/Anti-KIT Program

​

$

42,645

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$

30,472

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$

82,348

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$

54,250

CDX-622

​

3,838

​

3,126

​

9,289

​

6,547

Other Programs (a)

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7,713

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6,089

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15,173

​

10,551

Total R&D Expense

​

$

54,196

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$

39,687

​

$

106,810

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$

71,348

​

(a) Other program expenses primarily include research and development expenses related to early-stage programs, revenue-generating programs and discontinued programs.

The following table is a summary of the Company’s research and development expenses disaggregated by nature.

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Three Months Ended

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Three Months Ended

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Six Months Ended

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Six Months Ended

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June 30, 2025

June 30, 2024

June 30, 2025

June 30, 2024

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(In thousands)

Personnel

​

$

14,129

​

$

11,881

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$

27,729

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$

23,321

Laboratory supplies

​

1,544

​

1,615

​

3,712

​

2,923

Facility

​

1,398

​

1,250

​

2,803

​

2,536

Product development (b)

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33,536

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22,667

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65,702

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38,192

Other expenses (c)

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3,589

​

2,274

​

6,864

​

4,376

Total R&D expense

​

$

54,196

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$

39,687

​

$

106,810

​

$

71,348

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(b) Product development expenses include clinical investigator site fees, external trial monitoring costs, data accumulation costs, contracted research and outside clinical drug product manufacturing.

(c) Other expenses primarily include research and development consulting, insurance, licensing and software expenses.

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- Definition

The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments.

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