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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOW - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2025 | Sep. 30, 2024
Cash flows from operating activities: |  |
Net loss | $ (177,440) | $ (110,771)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 2,564 | 2,358
Amortization and premium of marketable securities, net | (4,973) | (12,386)
Loss on sale or disposal of assets | 12 | 12
Stock-based compensation expense | 27,308 | 24,462
Changes in operating assets and liabilities: |  |
Accounts and other receivables | 610 | 1,776
Prepaid and other current assets | 235 | (19,961)
Other assets | 383 | (9,640)
Accounts payable and accrued expenses | 6,430 | 3,640
Other liabilities | (2,134) | (4,792)
Net cash used in operating activities | (147,005) | (125,302)
Cash flows from investing activities: |  |
Sales and maturities of marketable securities | 484,788 | 347,732
Purchases of marketable securities | (329,708) | (660,745)
Acquisition of property and equipment | (1,433) | (1,163)
Net cash provided by (used in) investing activities | 153,647 | (314,176)
Cash flows from financing activities: |  |
Net proceeds from stock issuances |  | 432,298
Proceeds from issuance of stock from employee benefit plans | 1,039 | 8,765
Net cash provided by financing activities | 1,039 | 441,063
Net increase in cash and cash equivalents | 7,681 | 1,585
Cash and cash equivalents at beginning of period | 28,356 | 34,814
Cash and cash equivalents at end of period | 36,037 | 36,399
Non-cash investing activities |  |
Accrued construction in progress | $ 472 | $ 232

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- Definition Amount of cash and cash equivalent, and cash and cash equivalent restricted to withdrawal or usage; attributable to continuing operation. Cash includes, but is not limited to, currency on hand, demand deposit with financial institution, and account with general characteristic of demand deposit. Cash equivalent includes, but is not limited to, short-term, highly liquid investment that is both readily convertible to known amount of cash and so near maturity that it presents insignificant risk of change in value because of change in interest rate. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 8 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482913/230-10-50-8 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 24 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-24 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 4 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-4 + Details
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