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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Revenues:        
Total revenues   $ 3,191 $ 1,424 $ 5,845
Operating expenses:        
Research and development $ 62,931 45,263 169,741 116,611
General and administrative 10,686 10,054 31,897 28,285
Total operating expenses 73,617 55,317 201,638 144,896
Operating loss (73,617) (52,126) (200,214) (139,051)
Investment and other income, net 6,573 10,005 22,774 28,280
Net loss $ (67,044) $ (42,121) $ (177,440) $ (110,771)
Basic net loss per common share (in dollars per share) $ (1.01) $ (0.64) $ (2.67) $ (1.74)
Diluted net loss per common share (in dollars per share) $ (1.01) $ (0.64) $ (2.67) $ (1.74)
Shares used in calculating basic net loss per share (in shares) 66,420 66,294 66,399 63,737
Shares used in calculating diluted net loss per share (in shares) 66,420 66,294 66,399 63,737
Comprehensive loss:        
Net loss $ (67,044) $ (42,121) $ (177,440) $ (110,771)
Other comprehensive (loss) income:        
Unrealized gain on marketable securities 426 3,508 451 1,980
Comprehensive loss $ (66,618) (38,613) (176,989) (108,791)
Product development and licensing agreements        
Revenues:        
Total revenues   3 57 5
Contracts and grants        
Revenues:        
Total revenues   $ 3,188 $ 1,367 $ 5,840