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Stockholders' Equity (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2024
Jun. 30, 2024
Mar. 31, 2024
Sep. 30, 2025
Sep. 30, 2024
Increase (Decrease) in Stockholders' Equity                
Balance, beginning $ 655,406 $ 702,981 $ 747,005 $ 813,659 $ 838,613 $ 429,171 $ 747,005 $ 429,171
Balance, beginning (in shares)     66,374,549       66,374,549  
Shares issued under stock option and employee stock purchase plans 774 63 $ 202 1,239 3,712 3,814    
Shares issued in underwritten offering, net           432,298    
Stock-based compensation 8,801 9,191 9,316 9,620 7,640 7,202    
Unrealized gain on marketable securities 426 (229) 254 3,508 (464) (1,064) $ 451 1,980
Net Income (Loss) (67,044) (56,600) (53,796) (42,121) (35,842) (32,808) (177,440) (110,771)
Balance, ending $ 598,363 655,406 702,981 785,905 813,659 838,613 $ 598,363 785,905
Balance, ending (in shares) 66,446,846           66,446,846  
Common Stock                
Increase (Decrease) in Stockholders' Equity                
Balance, beginning $ 66 $ 66 $ 66 $ 66 $ 66 $ 56 $ 66 $ 56
Balance, beginning (in shares) 66,394,241 66,384,191 66,374,549 66,280,667 65,910,548 55,883,377 66,374,549 55,883,377
Shares issued under stock option and employee stock purchase plans (in shares) 52,605 10,050 9,642 63,569 370,119 229,171    
Shares issued in underwritten offering, net           $ 10    
Shares issued in underwritten offering, net (in shares)           9,798,000    
Balance, ending $ 66 $ 66 $ 66 $ 66 $ 66 $ 66 $ 66 $ 66
Balance, ending (in shares) 66,446,846 66,394,241 66,384,191 66,344,236 66,280,667 65,910,548 66,446,846 66,344,236
Additional Paid-In Capital                
Increase (Decrease) in Stockholders' Equity                
Balance, beginning $ 2,317,621 $ 2,308,367 $ 2,298,849 $ 2,277,824 $ 2,266,472 $ 1,823,168 $ 2,298,849 $ 1,823,168
Shares issued under stock option and employee stock purchase plans 774 63 202 1,239 3,712 3,814    
Shares issued in underwritten offering, net           432,288    
Stock-based compensation 8,801 9,191 9,316 9,620 7,640 7,202    
Balance, ending 2,327,196 2,317,621 2,308,367 2,288,683 2,277,824 2,266,472 2,327,196 2,288,683
Accumulated Other Comprehensive Income                
Increase (Decrease) in Stockholders' Equity                
Balance, beginning 3,339 3,568 3,314 1,780 2,244 3,308 3,314 3,308
Unrealized gain on marketable securities 426 (229) 254 3,508 (464) (1,064)    
Balance, ending 3,765 3,339 3,568 5,288 1,780 2,244 3,765 5,288
Accumulated Deficit                
Increase (Decrease) in Stockholders' Equity                
Balance, beginning (1,665,620) (1,609,020) (1,555,224) (1,466,011) (1,430,169) (1,397,361) (1,555,224) (1,397,361)
Net Income (Loss) (67,044) (56,600) (53,796) (42,121) (35,842) (32,808)    
Balance, ending $ (1,732,664) $ (1,665,620) $ (1,609,020) $ (1,508,132) $ (1,466,011) $ (1,430,169) $ (1,732,664) $ (1,508,132)