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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Cash flows from operating activities:    
Net loss $ (16,298) $ (10,867)
Adjustments to reconcile net loss to net cash used in operating activities:    
Share-based compensation expense 6,533 5,704
Depreciation 3,304 2,405
Amortization of intangible assets 908 1,066
Amortization of deferred financing costs 46 99
Loss on disposal of property and equipment 83 11
Realized loss from foreign exchange on intercompany transactions 333  
Amortization/accretion on investments 472 322
Change in allowance for doubtful accounts 55 73
Change in value of contingent consideration   (8,032)
Other   95
Changes in operating assets and liabilities:    
Accounts receivable 571 (1,785)
Inventories (2,461) (4,555)
Other current assets (449) 833
Accounts payable 2,181 (539)
Accrued liabilities 557 (3,604)
Other noncurrent assets and liabilities 403 (813)
Net cash used in operating activities (3,762) (19,587)
Cash flows from investing activities:    
Purchases of available-for-sale securities (19,525) (31,412)
Sales and maturities of available-for-sale securities 29,174 14,614
Purchases of property and equipment (8,287) (4,389)
Increases in property under build-to-suit obligation (9,128)  
Net cash used in investing activities (7,766) (21,187)
Cash flows from financing activities:    
Proceeds from sale of stock, net of offering costs of $0 and $257, respectively   65,830
Payments on debt and capital leases (36) (6,362)
Increases in build-to-suit obligation 9,128  
Proceeds from tax incentive loan 340  
Payment of debt fees and premium on retirement of debt (62) (181)
Proceeds from stock option exercises 2,421 1,657
Shares repurchased for payment of taxes on stock awards (650) (198)
Proceeds from issuance of common stock under employee stock purchase plan 906 708
Net cash provided by financing activities 12,047 61,454
Effect of exchange rate changes on cash and cash equivalents (189) (46)
Net increase in cash and cash equivalents 330 20,634
Cash and cash equivalents-beginning of period 28,384 14,892
Cash and cash equivalents-end of period 28,714 35,526
Supplemental cash flow information:    
Cash paid for interest 4 113
Cash paid for taxes 20 146
Non-cash investing and financing activities:    
Accrued purchases of property and equipment 2,442 2,572
Assets acquired through capital lease $ 50 $ 8