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Financial instruments, Changes in liabilities arising from financing activities (Details)
$ in Millions
 12 Months Ended
Dec. 31, 2020
GBP (£)
Property
Dec. 31, 2019
GBP (£)
Dec. 31, 2020
USD ($)
Property
Changes in liabilities arising from financing activities [abstract]      
Liabilities from financing activities £ 64,534,000 £ 65,433,000  
Cash flows 32,826,000 (4,036,000)  
Foreign exchange movement (1,306,000) (554,000)  
Net finance (income)/costs (579,000) 8,907,000  
Leases (8,591,000) (5,216,000)  
Other (22,997,000)    
Liabilities from financing activities 63,887,000 64,534,000  
Proceeds from agreement £ 36,654,000 0  
Number of leasehold properties terminated | Property 2   2
Lease liabilities £ 27,233,000 40,250,000  
Addition of new leases 453,000 897,000  
IFRS 16 [Member]      
Changes in liabilities arising from financing activities [abstract]      
Lease remeasurements 1,093,000 6,113,000  
Addition of new leases 422,000 897,000  
Leasehold Properties [Member]      
Changes in liabilities arising from financing activities [abstract]      
Lease liabilities 10,414,000 0  
Oxford Debt Agreement [Member]      
Changes in liabilities arising from financing activities [abstract]      
Proceeds from agreement | $     $ 50
Interest Bearing Loans and Borrowings [Member]      
Changes in liabilities arising from financing activities [abstract]      
Liabilities from financing activities 19,157,000 18,878,000  
Cash flows 37,252,000 0  
Foreign exchange movement (1,306,000) (563,000)  
Net finance (income)/costs 708,000 842,000  
Leases 0 0  
Other (19,157,000)    
Liabilities from financing activities 36,654,000 19,157,000  
Derivative Liability [Member]      
Changes in liabilities arising from financing activities [abstract]      
Liabilities from financing activities 5,127,000 0  
Cash flows 0 0  
Foreign exchange movement 0 0  
Net finance (income)/costs (1,287,000) 5,127,000  
Leases 0 0  
Other (3,840,000)    
Liabilities from financing activities 0 5,127,000  
Lease Liabilities [Member]      
Changes in liabilities arising from financing activities [abstract]      
Liabilities from financing activities 40,250,000 46,555,000  
Cash flows (4,426,000) (4,036,000)  
Foreign exchange movement 0 9,000  
Net finance (income)/costs 0 2,938,000  
Leases (8,591,000) (5,216,000)  
Other 0    
Liabilities from financing activities £ 27,233,000 £ 40,250,000