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Consolidated Statements of Cash Flows - GBP (£)
£ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Cash flows from operating activities      
Loss for the year £ (74,093) £ (103,931) £ (71,630)
Adjustments for:      
Depreciation of property, plant and equipment 6,446 6,549 6,410
Depreciation of right of use assets 2,530 2,454 0
Amortization of intangible assets 0 210 297
Write-off of intangible assets 0 306 170
Loss on disposal of property, plant and equipment 1,064 3 135
Gross gain from sale of equity investment 0 0 (5,204)
Profit on derecognition of leases (3,700) 0 0
Remeasurement of leases (227) 0 0
Net finance costs/(income) 1,167 7,867 (298)
Movement in provisions and other charges (41) 71 (50)
Foreign exchange translation differences (787) (618) 1,157
Equity settled share-based payment expenses 8,162 3,056 666
Taxation charge (13,267) (22,258) (16,548)
Working capital adjustments:      
(Increase) / decrease in trade and other receivables (532) 1,828 (1,522)
(Decrease) / increase in trade and other payables (3,774) 9,946 5,300
(Decrease)/increase in deferred liabilities (24,497) (21,866) 63,797
Cash used in operations (101,549) (116,383) (17,320)
Bank interest received on cash and cash equivalents 676 1,525 760
Net taxation received 40,299 13,482 (66)
Net cash used in operating activities (60,574) (101,376) (16,626)
Cash flows from investing activities      
Proceeds from sale of property, plant and equipment 675 82 0
Gross proceeds from disposal of equity investment 0 0 27,451
Purchase of property, plant and equipment (3,074) (4,078) (3,486)
Purchase of intangible assets 0 (198) (51)
Proceeds from sub-leases 378 57 0
Leasehold incentive 2,488 0 34,100
Net cash flows from / (used) in investing activities 467 (4,137) 58,014
Cash flows from financing activities      
Proceeds from exercise of share options 73 27 101
Gross proceeds from issue of share capital 83,218 59,874 0
Costs from issue of share capital (176) (738) 0
Non-current interest-bearing loan received 37,543 0 0
Interest paid on non-current interest-bearing loan repaid (291) 0 0
Repayment of lease liabilities (4,426) (4,036) 0
Net cash flows from financing activities 115,941 55,127 101
Increase / (decrease) in net cash and cash equivalents 55,834 (50,386) 41,489
Net foreign exchange difference on cash held (84) (33) 13
Cash and cash equivalents at beginning of the year 73,966 124,385 82,883
Cash and cash equivalents at end of the year £ 129,716 £ 73,966 £ 124,385