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Revenue, Revenue recognised (Details) - GBP (£) | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022
Revenue recognitions [Abstract] |  |  |  |
Product revenue, net | £ 45,514,000 | £ 23,992,000 | £ 87,566,000 | £ 31,674,000
Pre-product revenue, net | 0 | 3,708,000 | 0 | 6,537,000
Total revenue from sale of therapies | 45,514,000 | 27,700,000 | 87,566,000 | 38,211,000
Collaboration revenue | 2,250,000 | 4,302,000 | 4,739,000 | 16,265,000
Total revenue | 47,764,000 | 32,002,000 | 92,305,000 | 54,476,000
United States [Member] |  |  |  |
Revenue recognitions [Abstract] |  |  |  |
Total revenue from sale of therapies | 32,812,000 | 18,137,000 | 62,345,000 | 25,819,000
Europe [Member] |  |  |  |
Revenue recognitions [Abstract] |  |  |  |
Total revenue from sale of therapies | 12,189,000 | 9,560,000 | 24,517,000 | 12,389,000
Rest of World [Member] |  |  |  |
Revenue recognitions [Abstract] |  |  |  |
Total revenue from sale of therapies | 513,000 | 3,000 | 704,000 | 3,000
Eli Lilly [Member] |  |  |  |
Revenue recognitions [Abstract] |  |  |  |
Collaboration revenue | 0 | 0 | 0 | 7,361,000
Genentech [Member] |  |  |  |
Revenue recognitions [Abstract] |  |  |  |
Collaboration revenue | £ 2,250,000 | £ 4,302,000 | £ 4,739,000 | £ 8,904,000

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