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Revenue, Revenue recognised (Details) - GBP (£)	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenue recognitions [Abstract]
Product revenue, net	£ 45,514,000	£ 23,992,000	£ 87,566,000	£ 31,674,000
Pre-product revenue, net	0	3,708,000	0	6,537,000
Total revenue from sale of therapies	45,514,000	27,700,000	87,566,000	38,211,000
Collaboration revenue	2,250,000	4,302,000	4,739,000	16,265,000
Total revenue	47,764,000	32,002,000	92,305,000	54,476,000
United States [Member]
Revenue recognitions [Abstract]
Total revenue from sale of therapies	32,812,000	18,137,000	62,345,000	25,819,000
Europe [Member]
Revenue recognitions [Abstract]
Total revenue from sale of therapies	12,189,000	9,560,000	24,517,000	12,389,000
Rest of World [Member]
Revenue recognitions [Abstract]
Total revenue from sale of therapies	513,000	3,000	704,000	3,000
Eli Lilly [Member]
Revenue recognitions [Abstract]
Collaboration revenue	0	0	0	7,361,000
Genentech [Member]
Revenue recognitions [Abstract]
Collaboration revenue	£ 2,250,000	£ 4,302,000	£ 4,739,000	£ 8,904,000

X

- Definition

The income arising in the course of an entity's ordinary activities. Income is increases in assets, or decreases in liabilities, that result in increases in equity, other than those relating to contributions from holders of equity claims.

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The amount of revenue from contracts with customers. A customer is a party that has contracted with an entity to obtain goods or services that are an output of the entity’s ordinary activities in exchange for consideration.

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