<SEC-DOCUMENT>0001209191-21-023869.txt : 20210331
<SEC-HEADER>0001209191-21-023869.hdr.sgml : 20210331
<ACCEPTANCE-DATETIME>20210331191214
ACCESSION NUMBER:		0001209191-21-023869
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210330
FILED AS OF DATE:		20210331
DATE AS OF CHANGE:		20210331

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ROOT JONATHAN D
		CENTRAL INDEX KEY:			0001225480

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40236
		FILM NUMBER:		21795313

	MAIL ADDRESS:	
		STREET 1:		2735 SAND HILL ROAD
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Edgewise Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001710072
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				821725586
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		C/O ORBIMED ADVISORS LLC
		STREET 2:		601 LEXINGTON AVE, 54TH FLR.
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-739-6451

	MAIL ADDRESS:	
		STREET 1:		C/O ORBIMED ADVISORS LLC
		STREET 2:		601 LEXINGTON AVE, 54TH FLR.
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
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        <issuerName>Edgewise Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>EWTX</issuerTradingSymbol>
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            <rptOwnerCik>0001225480</rptOwnerCik>
            <rptOwnerName>ROOT JONATHAN D</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EDGEWISE THERAPEUTICS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>3145 COLORADO AVE.</rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80303</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
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            <transactionDate>
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    <derivativeTable>
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                </transactionPricePerShare>
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                    <value>See Footnotes</value>
                    <footnoteId id="F2"/>
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        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series B-2 Preferred Stock</value>
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                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
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                <footnoteId id="F1"/>
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            <expirationDate>
                <footnoteId id="F1"/>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1366707</value>
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                    <value>0</value>
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                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series C Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.00</value>
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            <transactionDate>
                <value>2021-03-30</value>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>455229</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
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                <footnoteId id="F1"/>
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            <expirationDate>
                <footnoteId id="F1"/>
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                    <value>0</value>
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                <directOrIndirectOwnership>
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                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F2"/>
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    <footnotes>
        <footnote id="F1">Each share of Series A Preferred Stock, Series B-1 Preferred Stock, Series B-2 Preferred Stock and Series C Preferred Stock converted into one share of the Issuer's Common Stock immediately prior to the completion of the Issuer's initial public offering.   The Preferred Stock had no expiration date.</footnote>
        <footnote id="F2">These securities are held of record by U.S. Venture Partners XI, L.P. (&quot;USVP XI&quot;).  Presidio Management Group XI, L.L.C. (&quot;PMG XI&quot;), the general partner of USVP XI, has sole voting and dispositive power with respect to the shares held by USVP XI.  The Reporting Person is a managing member of PMG XI with additional rights with respect to the issuer's securities, and may be deemed to have sole voting and dispositive power with respect to such shares.   Each of the foregoing persons disclaims beneficial ownership of such securities, except to the extent of any pecuniary interest therein.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ John R. Moore Attorney-in-Fact for Jonathan Root M.D.</signatureName>
        <signatureDate>2021-03-31</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
