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Description of business and basis of presentation (Details Textual) (USD $)
 3 Months Ended 6 Months Ended 256 Months Ended
Mar. 31, 2012
Jun. 30, 2012
Jun. 30, 2011
Jun. 30, 2012
Dec. 31, 2011
Description of business and basis of presentation (Textual) [Abstract]          
Deficit accumulated during the development stage   $ (2,010,298,000)   $ (2,010,298,000) $ (1,935,546,000)
Goodwill impairment       151,428,000  
Negative cash flow from operation since inception   57,504,000 67,447,000 1,533,905,000  
Cash, cash equivalents and marketable securities   32,000,000   32,000,000  
Borrowings under loan agreement   26,900,000   26,900,000  
Maturity period of cash equivalents   90 days or less at the time of purchase      
Available for sale securities, maturity period   greater than 90 days      
Cash equivalents   31,600,000   31,600,000 2,700,000
Available for sale securities and certificate of deposit   350,000   350,000 515,000
Loss on available-for-sale securities $ 117,000 $ 117,000   $ 990,000