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Condensed Consolidated Statements of Operations (Unaudited) (USD $)
In Thousands, except Per Share data, unless otherwise specified
 3 Months Ended 6 Months Ended 256 Months Ended
Jun. 30, 2012
Jun. 30, 2011
Jun. 30, 2012
Jun. 30, 2011
Jun. 30, 2012
Condensed Consolidated Statements of Operations [Abstract]          
Revenue       $ 50 $ 3,131
Operating expenses:          
Research and development 26,638 30,296 50,794 56,585 1,416,845
General and administrative 17,416 8,890 27,193 20,652 407,424
In-process research and development costs         19,726
Goodwill impairment         151,428
Total operating expenses 44,054 39,186 77,987 77,237 1,995,423
Loss from operations (44,054) (39,186) (77,987) (77,187) (1,992,292)
Other income 13,347 47 14,729 1,397 13,653
Interest expense on note payable to related party (3,028) (2,509) (6,076) (4,985) (34,410)
Interest expense on senior convertible notes (2,844) (2,834) (5,419) (5,247) (34,213)
Interest income 1 2 2 17 36,990
Loss before provision for income taxes (36,578) (44,480) (74,751) (86,005) (2,010,272)
Income taxes         (26)
Net loss (36,578) (44,480) (74,751) (86,005) (2,010,298)
Deemed dividend related to beneficial conversion feature of convertible preferred stock         (22,260)
Accretion on redeemable convertible preferred stock         (952)
Net loss applicable to common stockholders $ (36,578) $ (44,480) $ (74,751) $ (86,005) $ (2,033,510)
Net loss per share applicable to common stockholders - basic and diluted $ (0.23) $ (0.37) $ (0.49) $ (0.71)  
Shares used to compute basic and diluted net loss per share applicable to common stockholders 159,859 121,708 151,506 121,385