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Description of business and basis of presentation (Details Textual) (USD $) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 260 Months Ended |
--- | --- | --- | --- | --- | ---
Oct. 31, 2012 | Mar. 31, 2012 | Sep. 30, 2012 | Sep. 30, 2011 | Sep. 30, 2012 | Dec. 31, 2011
Subsidiary, Sale of Stock [Line Items] |  |  |  |  |  |
Underwritten public offering | 40,000,000 |  |  |  |  |
Description of business and basis of presentation (Textual) [Abstract] |  |  |  |  |  |
Deficit accumulated during the development stage |  |  | $ (2,053,131,000) |  | $ (2,053,131,000) | $ (1,935,546,000)
Goodwill impairment |  |  |  |  | 151,428,000 |
Negative cash flow from operation since inception |  |  | 91,762,000 | 103,482,000 | 1,568,163,000 |
Cash, cash equivalents and marketable securities |  |  | 2,100,000 |  | 2,100,000 |
Borrowings under loan agreement |  |  | 21,900,000 |  | 21,900,000 |
Additional common stock shares issued | 6,000,000 |  | 6,000,000 |  |  |
Common Stock Purchase | 30,000,000 |  | 30,000,000 |  |  |
Additional Purchase Of Common Stock | 4,500,000 |  | 4,500,000 |  |  |
Net proceeds from public offering | 86,000,000 |  | 86,000,000 |  |  |
Maturity period of cash equivalents |  |  | 90 days or less at the time of purchase |  |  |
Available for sale securities, maturity period |  |  | greater than 90 days |  |  |
Cash equivalents |  |  | 1,800,000 |  | 1,800,000 | 2,700,000
Available-for-sale securities and certificate of deposit |  |  | 350,000 |  | 350,000 | 515,000
Loss on available-for-sale securities |  | $ 117,000 | $ 117,000 |  | $ 990,000 |
IPO [Member] |  |  |  |  |  |
Subsidiary, Sale of Stock [Line Items] |  |  |  |  |  |
Underwritten public offering |  |  | 40,000,000 |  |  |

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