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Description of business and basis of presentation (Details Textual) (USD $)
 1 Months Ended 3 Months Ended 9 Months Ended 260 Months Ended
Oct. 31, 2012
Mar. 31, 2012
Sep. 30, 2012
Sep. 30, 2011
Sep. 30, 2012
Dec. 31, 2011
Subsidiary, Sale of Stock [Line Items]            
Underwritten public offering 40,000,000          
Description of business and basis of presentation (Textual) [Abstract]            
Deficit accumulated during the development stage     $ (2,053,131,000)   $ (2,053,131,000) $ (1,935,546,000)
Goodwill impairment         151,428,000  
Negative cash flow from operation since inception     91,762,000 103,482,000 1,568,163,000  
Cash, cash equivalents and marketable securities     2,100,000   2,100,000  
Borrowings under loan agreement     21,900,000   21,900,000  
Additional common stock shares issued 6,000,000   6,000,000      
Common Stock Purchase 30,000,000   30,000,000      
Additional Purchase Of Common Stock 4,500,000   4,500,000      
Net proceeds from public offering 86,000,000   86,000,000      
Maturity period of cash equivalents     90 days or less at the time of purchase      
Available for sale securities, maturity period     greater than 90 days      
Cash equivalents     1,800,000   1,800,000 2,700,000
Available-for-sale securities and certificate of deposit     350,000   350,000 515,000
Loss on available-for-sale securities   $ 117,000 $ 117,000   $ 990,000  
IPO [Member]
            
Subsidiary, Sale of Stock [Line Items]            
Underwritten public offering     40,000,000