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Components of Net Deferred Tax Asset (Detail) (USD $) In Thousands, unless otherwise specified | Dec. 31, 2012 | Dec. 31, 2011
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 609,471 | $ 557,427
Research and development credits | 65,315 | 59,848
Capitalized research | 31,490 | 32,440
Accrued expenses | 2,922 | 2,827
Non-qualified stock option expense | 30,928 | 27,964
Depreciation | 10,025 | 8,906
Total net deferred tax assets | 750,151 | 689,412
Valuation allowance | (750,151) | (689,412)
Net deferred tax assets |  |

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