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Description of Business and Basis of Presentation - Additional Information (Detail) (USD $) | 1 Months Ended | 12 Months Ended | 263 Months Ended |  |  |  | 12 Months Ended |  |  | 1 Months Ended |  |
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Dec. 31, 2012 | Oct. 31, 2007 | Dec. 12, 2001 | Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2002 | Dec. 31, 2012 | Oct. 31, 2012 | Dec. 31, 2009 | Oct. 31, 2012 After Amendment | Dec. 31, 2012 Senior convertible notes due December 15, 2013 | Dec. 31, 2011 Senior convertible notes due December 15, 2013 | Dec. 12, 2006 Senior convertible notes due December 15, 2013 | Dec. 31, 2012 Maximum | Dec. 12, 2001 PDC | Dec. 12, 2001 AlleCure | Dec. 12, 2001 CTL | Oct. 31, 2012 Mann Group
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deficit accumulated during the development stage | $ (2,104,912,000) |  |  | $ (2,104,912,000) | $ (1,935,546,000) |  |  | $ (2,104,912,000) |  |  |  |  |  |  |  |  |  |  |
Goodwill impairment |  |  |  |  |  |  | 151,400,000 | 151,428,000 |  |  |  |  |  |  |  |  |  |  |
Negative cash flow from operation since inception |  |  |  | (119,860,000) | (123,837,000) | (148,654,000) |  | (1,596,261,000) |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents | 61,840,000 |  |  | 61,840,000 | 2,681,000 | 66,061,000 |  | 61,840,000 |  | 30,019,000 |  |  |  |  |  |  |  |  |
Loan agreement with related party |  | 350,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Promissory note maturity date | Jan. 01, 2014 |  |  |  |  |  |  |  |  |  |  | Dec. 15, 2013 |  |  |  |  |  |  |
Borrowing date of promissory note |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Sep. 30, 2013 |  |  |  |
Interest rate (LIBOR) | 5.00% |  |  | 5.00% |  |  |  | 5.00% |  |  |  |  |  |  |  |  |  |  |
Description of variable rate interest | annual interest rate on all outstanding principal to the one-year London Interbank Offered Rate (LIBOR) on December 31, 2012 plus 5%, effective January 1, 2013 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of aggregate warrant and restricted shares purchase price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 107,400,000
Amended and restated promissory note outstanding principal amount |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 350,000,000
Loan arrangement principal amount outstanding | 119,635,000 |  |  | 119,635,000 | 277,203,000 |  |  | 119,635,000 |  |  | 119,600,000 |  |  |  |  |  |  |  |
Available borrowing under the amended and restated promissory note | 12,750,000 |  |  | 12,750,000 | 45,000,000 |  |  | 12,750,000 | 125,400,000 |  |  |  |  |  |  |  |  |  |
Principal amount of convertible senior notes |  |  |  |  |  |  |  |  |  |  |  | 115,000,000 | 115,000,000 | 115,000,000 |  |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  |  |  |  |  | 3.75% |  | 3.75% |  |  |  |  |
Percentage of ownership |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 76.00% | 59.00% | 69.00% |
In-process research and development costs |  |  | 19,700,000 |  |  |  |  | 19,726,000 |  |  |  |  |  |  |  |  |  |  |
Goodwill |  |  | $ 151,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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