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Consolidated Statements of Stockholders' Equity (Deficit) (USD $) In Thousands, except Share data | Total | Series B Convertible Preferred Stock | Series C Convertible Preferred Stock | Series C Convertible Preferred Stock Issuable | Series C Convertible Preferred Stock Subscriptions Receivable | Common Stock | Additional Paid-in Capital | Notes Receivable from Stockholders | Notes Receivable from Officers | Other Comprehensive Income (Loss) | Deficit Accumulated During the Development Stage
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning Balance at Feb. 13, 1991 |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 998,000 |  |  |  |  |
Issuance of common stock | $ 900 |  |  |  |  | $ 10 | $ 890 |  |  |  |
Net loss | (911) |  |  |  |  |  |  |  |  |  | (911)
Ending Balance at Feb. 29, 1992 | (11) |  |  |  |  | 10 | 890 |  |  |  | (911)
Ending Balance (in shares) at Feb. 29, 1992 |  |  |  |  |  | 998,000 |  |  |  |  |
Capital contribution | 20 |  |  |  |  |  | 20 |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 73,000 |  |  |  |  |
Issuance of common stock | 888 |  |  |  |  | 1 | 887 |  |  |  |
Net loss | (1,175) |  |  |  |  |  |  |  |  |  | (1,175)
Ending Balance at Feb. 28, 1993 | (278) |  |  |  |  | 11 | 1,797 |  |  |  | (2,086)
Ending Balance (in shares) at Feb. 28, 1993 |  |  |  |  |  | 1,071,000 |  |  |  |  |
Issuance of stock for notes receivable (in shares) |  |  |  |  |  | 8,000 |  |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 11,000 |  |  |  |  |
Issuance of common stock | 526 |  |  |  |  |  | 526 |  |  |  |
Issuance of stock for notes receivable |  |  |  |  |  |  | 400 | (400) |  |  |
Net loss | (1,156) |  |  |  |  |  |  |  |  |  | (1,156)
Ending Balance at Feb. 28, 1994 | (908) |  |  |  |  | 11 | 2,723 | (400) |  |  | (3,242)
Ending Balance (in shares) at Feb. 28, 1994 |  |  |  |  |  | 1,090,000 |  |  |  |  |
Collection of stock subscription | 400 |  |  |  |  |  |  | 400 |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 36,000 |  |  |  |  |
Issuance of common stock | 1,805 |  |  |  |  |  | 1,805 |  |  |  |
Net loss | (2,004) |  |  |  |  |  |  |  |  |  | (2,004)
Ending Balance at Dec. 31, 1994 | (707) |  |  |  |  | 11 | 4,528 |  |  |  | (5,246)
Ending Balance (in shares) at Dec. 31, 1994 |  |  |  |  |  | 1,126,000 |  |  |  |  |
Issuance of common stock for services | 8 |  |  |  |  |  | 8 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 1,000 |  |  |  |  |
Exercise of stock options | 22 |  |  |  |  |  | 22 |  |  |  |
Stock-based compensation | 384 |  |  |  |  |  | 384 |  |  |  |
Net loss | (2,815) |  |  |  |  |  |  |  |  |  | (2,815)
Ending Balance at Dec. 31, 1995 | (3,108) |  |  |  |  | 11 | 4,942 |  |  |  | (8,061)
Ending Balance (in shares) at Dec. 31, 1995 |  |  |  |  |  | 1,127,000 |  |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 1,000 |  |  |  |  |
Issuance of common stock | 59 |  |  |  |  |  | 59 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 3,000 |  |  |  |  |
Exercise of stock options | 12 |  |  |  |  |  | 12 |  |  |  |
Stock-based compensation | 126 |  |  |  |  |  | 126 |  |  |  |
Net loss | (2,570) |  |  |  |  |  |  |  |  |  | (2,570)
Ending Balance at Dec. 31, 1996 | (5,481) |  |  |  |  | 11 | 5,139 |  |  |  | (10,631)
Ending Balance (in shares) at Dec. 31, 1996 |  |  |  |  |  | 1,131,000 |  |  |  |  |
Conversion of notes payable (in shares) |  |  |  |  |  | 12,000 |  |  |  |  |
Conversion of notes payable | 60 |  |  |  |  |  | 60 |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 548,000 |  |  |  |  |
Issuance of common stock | 196 |  |  |  |  | 6 | 190 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 27,000 |  |  |  |  |
Exercise of stock options | 135 |  |  |  |  |  | 135 |  |  |  |
Stock-based compensation | 2 |  |  |  |  |  | 2 |  |  |  |
Net loss | (2,280) |  |  |  |  |  |  |  |  |  | (2,280)
Ending Balance at Dec. 31, 1997 | (7,368) |  |  |  |  | 17 | 5,526 |  |  |  | (12,911)
Ending Balance (in shares) at Dec. 31, 1997 |  |  |  |  |  | 1,718,000 |  |  |  |  |
Conversion of notes payable (in shares) |  |  |  |  |  | 215,000 |  |  |  |  |
Conversion of notes payable | 1,202 |  |  |  |  | 2 | 1,200 |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 2,253,000 |  |  |  |  |
Issuance of common stock | 12,726 |  |  |  |  | 23 | 12,703 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 68,000 |  |  |  |  |
Exercise of stock options | 25 |  |  |  |  | 1 | 24 |  |  |  |
Stock-based compensation | 150 |  |  |  |  |  | 150 |  |  |  |
Net loss | (3,331) |  |  |  |  |  |  |  |  |  | (3,331)
Ending Balance at Dec. 31, 1998 | 3,404 |  |  |  |  | 43 | 19,603 |  |  |  | (16,242)
Ending Balance (in shares) at Dec. 31, 1998 |  |  |  |  |  | 4,254,000 |  |  |  |  |
Conversion of notes payable (in shares) |  |  |  |  |  | 80,000 |  |  |  |  |
Conversion of notes payable | 995 |  |  |  |  | 1 | 994 |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 162,000 |  |  |  |  |
Issuance of common stock | 534 |  |  |  |  | 2 | 532 |  |  |  |
Net loss | (5,679) |  |  |  |  |  |  |  |  |  | (5,679)
Ending Balance at Dec. 31, 1999 | (746) |  |  |  |  | 46 | 21,129 |  |  |  | (21,921)
Ending Balance (in shares) at Dec. 31, 1999 |  |  |  |  |  | 4,496,000 |  |  |  |  |
Conversion of notes payable (in shares) |  |  |  |  |  | 63,000 |  |  |  |  |
Conversion of notes payable | 1,074 |  |  |  |  | 1 | 1,073 |  |  |  |
Issuance of Series B preferred stock for cash (in shares) |  | 193,000 |  |  |  |  |  |  |  |  |
Issuance of Series B preferred stock for cash | 15,000 | 15,000 |  |  |  |  |  |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 4,690,000 |  |  |  |  |
Issuance of common stock | 31,633 |  |  |  |  | 46 | 33,945 | (2,358) |  |  |
Discount on notes below market rate | 241 |  |  |  |  |  |  | 241 |  |  |
Amount in excess of redemption obligation | 999 |  |  |  |  |  | 999 |  |  |  |
Accrued interest on notes | (117) |  |  |  |  |  |  | (117) |  |  |
Beneficial conversion feature of Series A/B convertible preferred stock | (993) |  |  |  |  |  | (993) |  |  |  |
Accretion to redemption value on Series A redeemable convertible preferred stock | (149) |  |  |  |  |  | (149) |  |  |  |
Stock-based compensation | 9,609 |  |  |  |  |  | 9,609 |  |  |  |
Net loss | (24,661) |  |  |  |  |  |  |  |  |  | (24,661)
Ending Balance at Dec. 31, 2000 | 31,890 | 15,000 |  |  |  | 93 | 65,613 | (2,234) |  |  | (46,582)
Ending Balance (in shares) at Dec. 31, 2000 |  | 193,000 |  |  |  | 9,249,000 |  |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 3,052,000 |  |  |  |  |
Issuance of common stock | 78,030 |  |  |  |  | 30 | 78,000 |  |  |  |
Issuance of common stock for services (in shares) |  |  |  |  |  | 3,000 |  |  |  |  |
Issuance of common stock for services | 60 |  |  |  |  |  | 60 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 1,000 |  |  |  |  |
Exercise of stock options | 13 |  |  |  |  |  | 13 |  |  |  |
Cash received for common stock issuable | 3,900 |  |  |  |  |  | 3,900 |  |  |  |
Issuance of put option by stockholder | (2,949) |  |  |  |  |  | (2,949) |  |  |  |
Payments on notes receivable | 28 |  |  |  |  |  |  | 28 |  |  |
Record merger of entities | 171,154 |  |  |  |  |  | 171,154 |  |  |  |
Accrued interest on notes | (189) |  |  |  |  |  |  | (189) |  |  |
Accretion to redemption value on Series A redeemable convertible preferred stock | (239) |  |  |  |  |  | (239) |  |  |  |
Stock-based compensation | 1,565 |  |  |  |  |  | 1,565 |  |  |  |
Net loss | (48,245) |  |  |  |  |  |  |  |  |  | (48,245)
Ending Balance at Dec. 31, 2001 | 235,018 | 15,000 |  |  |  | 123 | 317,117 | (2,395) |  |  | (94,827)
Ending Balance (in shares) at Dec. 31, 2001 |  | 193,000 |  |  |  | 12,305,000 |  |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 3,922,000 |  |  |  |  |
Issuance of common stock | 58,815 |  |  |  |  | 40 | 58,775 |  |  |  |
Issuance of common stock for cash already received (in shares) |  |  |  |  |  | 234,000 |  |  |  |  |
Issuance of common stock for cash already received |  |  |  |  |  | 2 | (2) |  |  |  |
Cash received for common stock issuable | 98 |  |  |  |  |  | 98 |  |  |  |
Issuance of stock award to employee/consultants (in shares) |  |  |  |  |  | 3,000 |  |  |  |  |
Issuance of stock award to employee/consultants | 84 |  |  |  |  |  | 84 |  |  |  |
Payments on notes receivable | 1,314 |  |  |  |  |  |  | 1,314 |  |  |
Put option redemption by stockholder | 1,921 |  |  |  |  |  | 1,921 |  |  |  |
Accrued interest on notes | (229) |  |  |  |  |  |  | (229) |  |  |
Deemed dividend related to beneficial conversion feature of convertible preferred stock | (1,421) |  |  |  |  |  | (1,421) |  |  |  |
Beneficial conversion feature of Series A/B convertible preferred stock | 1,421 |  |  |  |  |  | 1,421 |  |  |  |
Accretion to redemption value on Series A redeemable convertible preferred stock | (251) |  |  |  |  |  | (251) |  |  |  |
Stock-based compensation | 268 |  |  |  |  |  | 268 |  |  |  |
Net loss | (206,265) |  |  |  |  |  |  |  |  |  | (206,265)
Ending Balance at Dec. 31, 2002 | 90,773 | 15,000 |  |  |  | 165 | 378,010 | (1,310) |  |  | (301,092)
Ending Balance (in shares) at Dec. 31, 2002 |  | 193,000 |  |  |  | 16,464,000 |  |  |  |  |
Conversion of notes payable |  |  |  | 50,000 | (50,000) |  |  |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 3,494,000 |  |  |  |  |
Issuance of common stock | 50,000 |  |  |  |  | 35 | 49,965 |  |  |  |
Issuance of common stock for cash already received (in shares) |  |  |  |  |  | 17,000 |  |  |  |  |
Non-cash compensation expense of officer resulting from stockholder contribution | 70 |  |  |  |  |  | 70 |  |  |  |
Issuance of common stock for cash already received | 31,847 |  |  |  | 31,847 |  |  |  |  |  |
Notes receivable by stockholder issued to officers |  |  |  |  |  |  | 225 |  | (225) |  |
Put shares sold to majority stockholder | 623 |  |  |  |  |  | 623 |  |  |  |
Accrued interest on notes | (105) |  |  |  |  |  |  | (102) | (3) |  |
Deemed dividend related to beneficial conversion feature of convertible preferred stock | (1,017) |  |  |  |  |  | (1,017) |  |  |  |
Beneficial conversion feature of Series A/B convertible preferred stock | 1,017 |  |  |  |  |  | 1,017 |  |  |  |
Accretion to redemption value on Series A redeemable convertible preferred stock | (253) |  |  |  |  |  | (253) |  |  |  |
Stock-based compensation | 4,501 |  |  |  |  |  | 4,501 |  |  |  |
Net loss | (65,879) |  |  |  |  |  |  |  |  |  | (65,879)
Ending Balance at Dec. 31, 2003 | 111,577 | 15,000 |  | 50,000 | (18,153) | 200 | 433,141 | (1,412) | (228) |  | (366,971)
Ending Balance (in shares) at Dec. 31, 2003 |  | 193,000 |  |  |  | 19,975,000 |  |  |  |  |
Conversion of notes payable (in shares) |  |  | 356,000 |  |  |  |  |  |  |  |
Conversion of notes payable | 18,153 |  | 18,153 | (18,153) | 18,153 |  |  |  |  |  |
Issuance of common stock for cash already received (in shares) |  |  | 624,000 |  |  |  |  |  |  |  |
Issuance of common stock for cash already received |  |  | 31,847 | (31,847) |  |  |  |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 86,000 |  |  |  |  |
Exercise of stock options | 1,079 |  |  |  |  |  | 1,079 |  |  |  |
Exercise of warrants (in shares) |  |  |  |  |  | 4,000 |  |  |  |  |
Exercise of warrants | 46 |  |  |  |  |  | 46 |  |  |  |
Repayment of notes receivable by stockholder issued to officers | 3 |  |  |  |  |  | (225) |  | 228 |  |
Repayment of stock note receivable (in shares) |  |  |  |  |  | (90,000) |  |  |  |  |
Repayment of stock note receivable |  |  |  |  |  | (1) | (1,518) | 1,519 |  |  |
Conversion of Series A convertible preferred stock to common stock (in shares) |  |  |  |  |  | 891,000 |  |  |  |  |
Conversion of Series A convertible preferred stock to common stock | 5,248 |  |  |  |  | 9 | 5,239 |  |  |  |
Conversion of Series B convertible preferred stock to common stock (in shares) |  | (193,000) |  |  |  | 811,000 |  |  |  |  |
Conversion of Series B convertible preferred stock to common stock |  | (15,000) |  |  |  | 8 | 14,992 |  |  |  |
Conversion of Series C convertible preferred stock to common stock (in shares) |  |  | (980,000) |  |  | 4,464,000 |  |  |  |  |
Conversion of Series C convertible preferred stock to common stock |  |  | (50,000) |  |  | 45 | 49,955 |  |  |  |
Issuance of common shares in exchange for warrants (in shares) |  |  |  |  |  | 22,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan (in shares) |  |  |  |  |  | 36,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 430 |  |  |  |  |  | 430 |  |  |  |
Accrued interest on notes | (107) |  |  |  |  |  |  | (107) |  |  |
Issuance of common shares pursuant to underwritten public offerings (in shares) |  |  |  |  |  | 6,557,000 |  |  |  |  |
Issuance of common shares pursuant to underwritten public offerings | 83,176 |  |  |  |  | 66 | 83,110 |  |  |  |
Deemed dividend related to beneficial conversion feature of convertible preferred stock | (19,822) |  |  |  |  |  | (19,822) |  |  |  |
Beneficial conversion feature of Series A/B convertible preferred stock | 19,822 |  |  |  |  |  | 19,822 |  |  |  |
Accretion to redemption value on Series A redeemable convertible preferred stock | (60) |  |  |  |  |  | (60) |  |  |  |
Stock-based compensation | 6,810 |  |  |  |  |  | 6,810 |  |  |  |
Net loss | (75,992) |  |  |  |  |  |  |  |  |  | (75,992)
Ending Balance at Dec. 31, 2004 | 150,363 |  |  |  |  | 327 | 592,999 |  |  |  | (442,963)
Ending Balance (in shares) at Dec. 31, 2004 |  |  |  |  |  | 32,756,000 |  |  |  |  |
Issuance of common shares in exchange for warrants | 245 |  |  |  |  |  | 245 |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 17,132,000 |  |  |  |  |
Issuance of common stock | 170,234 |  |  |  |  | 171 | 170,063 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 304,000 |  |  |  |  |
Exercise of stock options | 1,951 |  |  |  |  | 3 | 1,948 |  |  |  |
Issuance of stock award to employee/consultants (in shares) |  |  |  |  |  | 40,000 |  |  |  |  |
Issuance of stock award to employee/consultants | (145) |  |  |  |  | 1 | (146) |  |  |  |
Issuance of common shares in exchange for warrants (in shares) |  |  |  |  |  | 24,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan (in shares) |  |  |  |  |  | 58,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 495 |  |  |  |  | 1 | 494 |  |  |  |
Stock-based compensation | (1,828) |  |  |  |  |  | (1,828) |  |  |  |
Net loss | (114,338) |  |  |  |  |  |  |  |  |  | (114,338)
Ending Balance at Dec. 31, 2005 | 206,977 |  |  |  |  | 503 | 763,775 |  |  |  | (557,301)
Ending Balance (in shares) at Dec. 31, 2005 |  |  |  |  |  | 50,314,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  |  |  |  | 102,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units | (340) |  |  |  |  | 1 | (341) |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 23,000,000 |  |  |  |  |
Issuance of common stock | 384,670 |  |  |  |  | 230 | 384,440 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 263,000 |  |  |  |  |
Exercise of stock options | 2,312 |  |  |  |  | 3 | 2,309 |  |  |  |
Exercise of warrants (in shares) |  |  |  |  |  | 339,000 |  |  |  |  |
Cancellation of common shares for stock notes receivable (in shares) |  |  |  |  |  | (844,000) |  |  |  |  |
Exercise of warrants | 2,694 |  |  |  |  | 3 | 2,691 |  |  |  |
Cancellation of common shares for stock notes receivable |  |  |  |  |  | (8) | 8 |  |  |  |
Issuance of common shares pursuant to research agreement (in shares) |  |  |  |  |  | 100,000 |  |  |  |  |
Issuance of common shares pursuant to research agreement | 2,074 |  |  |  |  | 1 | 2,073 |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan (in shares) |  |  |  |  |  | 86,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 981 |  |  |  |  | 1 | 980 |  |  |  |
Stock-based compensation | 14,667 |  |  |  |  |  | 14,667 |  |  |  |
Net loss | (230,548) |  |  |  |  |  |  |  |  |  | (230,548)
Ending Balance at Dec. 31, 2006 | 383,487 |  |  |  |  | 734 | 1,170,602 |  |  |  | (787,849)
Ending Balance (in shares) at Dec. 31, 2006 |  |  |  |  |  | 73,360,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  |  |  |  | 146,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units | (524) |  |  |  |  | 2 | (526) |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 27,014,000 |  |  |  |  |
Issuance of common stock | 249,750 |  |  |  |  | 270 | 249,480 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 607,000 |  |  |  |  |
Exercise of stock options | 4,923 |  |  |  |  | 6 | 4,917 |  |  |  |
Issuance of stock award to employee/consultants (in shares) |  |  |  |  |  | 30,000 |  |  |  |  |
Issuance of stock award to employee/consultants | 123 |  |  |  |  |  | 123 |  |  |  |
Issuance of common shares pursuant to research agreement (in shares) |  |  |  |  |  | 100,000 |  |  |  |  |
Issuance of common shares pursuant to research agreement | 944 |  |  |  |  | 1 | 943 |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan (in shares) |  |  |  |  |  | 124,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 1,065 |  |  |  |  | 1 | 1,064 |  |  |  |
Stock-based compensation | 17,522 |  |  |  |  |  | 17,522 |  |  |  |
Net loss | (293,190) |  |  |  |  |  |  |  |  |  | (293,190)
Ending Balance at Dec. 31, 2007 | 364,100 |  |  |  |  | 1,014 | 1,444,125 |  |  |  | (1,081,039)
Ending Balance (in shares) at Dec. 31, 2007 |  |  |  |  |  | 101,381,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  |  |  |  | 248,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units | (315) |  |  |  |  | 2 | (317) |  |  |  |
Issuance of stock award to employee/consultants (in shares) |  |  |  |  |  | 30,000 |  |  |  |  |
Issuance of stock award to employee/consultants | (18) |  |  |  |  |  | (18) |  |  |  |
Unrealized gain/(loss) on available-for-sale securities | 295 |  |  |  |  |  |  |  |  | 295 |
Issuance of common shares under Employee Stock Purchase Plan (in shares) |  |  |  |  |  | 349,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 900 |  |  |  |  | 4 | 896 |  |  |  |
Stock-based compensation | 24,811 |  |  |  |  |  | 24,811 |  |  |  |
Net loss | (303,039) |  |  |  |  |  |  |  |  |  | (303,039)
Ending Balance at Dec. 31, 2008 | 86,734 |  |  |  |  | 1,020 | 1,469,497 |  |  | 295 | (1,384,078)
Ending Balance (in shares) at Dec. 31, 2008 |  |  |  |  |  | 102,008,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  |  |  |  | 2,240,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units | (7,001) |  |  |  |  | 22 | (7,023) |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 8,360,000 |  |  |  |  |
Issuance of common stock | 59,724 |  |  |  |  | 84 | 59,640 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 94,000 |  |  |  |  |
Exercise of stock options | 383 |  |  |  |  | 1 | 382 |  |  |  |
Unrealized gain/(loss) on available-for-sale securities | (581) |  |  |  |  |  |  |  |  | (581) |
Issuance of common shares under Employee Stock Purchase Plan (in shares) |  |  |  |  |  | 323,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 1,400 |  |  |  |  | 3 | 1,397 |  |  |  |
Unrealized gain/(loss) on foreign currency translation | 5 |  |  |  |  |  |  |  |  | 5 |
Stock-based compensation | 20,219 |  |  |  |  |  | 20,219 |  |  |  |
Net loss | (220,104) |  |  |  |  |  |  |  |  |  | (220,104)
Ending Balance at Dec. 31, 2009 | (59,221) |  |  |  |  | 1,130 | 1,544,112 |  |  | (281) | (1,604,182)
Ending Balance (in shares) at Dec. 31, 2009 |  |  |  |  |  | 113,025,000 |  |  |  |  |
Conversion of notes payable (in shares) |  |  |  |  |  | 2,100,000 |  |  |  |  |
Conversion of notes payable | 16,681 |  |  |  |  | 21 | 16,660 |  |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  |  |  |  | 962,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units | (3,392) |  |  |  |  | 10 | (3,402) |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 2,100,000 |  |  |  |  |
Issuance of common stock | 14,335 |  |  |  |  | 21 | 14,314 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 318,000 |  |  |  |  |
Exercise of stock options | 924 |  |  |  |  | 3 | 921 |  |  |  |
Issuance of stock under share lending agreement (in shares) |  |  |  |  |  | 9,000,000 |  |  |  |  |
Issuance of stock under share lending agreement | 161 |  |  |  |  | 90 | 71 |  |  |  |
Unrealized gain/(loss) on available-for-sale securities | 361 |  |  |  |  |  |  |  |  | 361 |
Issuance of common shares under Employee Stock Purchase Plan (in shares) | 287,597 |  |  |  |  | 288,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 1,605 |  |  |  |  | 3 | 1,602 |  |  |  |
Unrealized gain/(loss) on foreign currency translation | (6) |  |  |  |  |  |  |  |  | (6) |
Stock-based compensation | 13,580 |  |  |  |  |  | 13,580 |  |  |  |
Net loss | (170,560) |  |  |  |  |  |  |  |  |  | (170,560)
Ending Balance at Dec. 31, 2010 | (185,532) |  |  |  |  | 1,278 | 1,587,858 |  |  | 74 | (1,774,742)
Ending Balance (in shares) at Dec. 31, 2010 |  |  |  |  |  | 127,793,000 |  |  |  |  |
Conversion of notes payable (in shares) |  |  |  |  |  | 1,400,000 |  |  |  |  |
Conversion of notes payable | 11,116 |  |  |  |  | 14 | 11,102 |  |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  |  |  |  | 433,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units | (543) |  |  |  |  | 4 | (547) |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 1,400,000 |  |  |  |  |
Issuance of common stock | 9,540 |  |  |  |  | 14 | 9,526 |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  | 214,000 |  |  |  |  |
Exercise of stock options | 628 |  |  |  |  | 2 | 626 |  |  |  |
Unrealized gain/(loss) on available-for-sale securities | (27) |  |  |  |  |  |  |  |  | (27) |
Issuance of common shares under Employee Stock Purchase Plan (in shares) | 282,816 |  |  |  |  | 283,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 769 |  |  |  |  | 3 | 766 |  |  |  |
Unrealized gain/(loss) on foreign currency translation | (3) |  |  |  |  |  |  |  |  | (3) |
Stock-based compensation | 11,204 |  |  |  |  |  | 11,204 |  |  |  |
Net loss | (160,804) |  |  |  |  |  |  |  |  |  | (160,804)
Ending Balance at Dec. 31, 2011 | (313,652) |  |  |  |  | 1,315 | 1,620,535 |  |  | 44 | (1,935,546)
Ending Balance (in shares) at Dec. 31, 2011 |  |  |  |  |  | 131,523,000 |  |  |  |  |
Conversion of notes payable (in shares) |  |  |  |  |  | 71,250,000 |  |  |  |  |
Conversion of notes payable | 184,537 |  |  |  |  | 713 | 183,824 |  |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  |  |  |  | 886,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units | (906) |  |  |  |  | 9 | (915) |  |  |  |
Exercise of stock options (in shares) | 3,216 |  |  |  |  | 3,000 |  |  |  |  |
Exercise of stock options | 9 |  |  |  |  |  | 9 |  |  |  |
Fair value of forward purchase contracts | 1,237 |  |  |  |  |  | 1,237 |  |  |  |
Issuance of common shares pursuant to litigation settlement (in shares) |  |  |  |  |  | 225,000 |  |  |  |  |
Issuance of common shares pursuant to litigation settlement | 438 |  |  |  |  | 2 | 436 |  |  |  |
Commitment to deliver common shares pursuant to litigation settlement to additional paid-in capital | 6,056 |  |  |  |  |  | 6,056 |  |  |  |
Reclassification adjustment for gains (losses) included in net loss | (48) |  |  |  |  |  |  |  |  | (48) |
Issuance of common shares under Employee Stock Purchase Plan (in shares) | 422,260 |  |  |  |  | 211,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 862 |  |  |  |  | 2 | 860 |  |  |  |
Unrealized gain/(loss) on foreign currency translation | (2) |  |  |  |  |  |  |  |  | (2) |
Issuance of common shares pursuant to underwritten public offerings (in shares) |  |  |  |  |  | 81,938,000 |  |  |  |  |
Issuance of common shares pursuant to underwritten public offerings | 166,864 |  |  |  |  | 819 | 166,045 |  |  |  |
Stock-based compensation | 13,292 |  |  |  |  |  | 13,292 |  |  |  |
Net loss | (169,366) |  |  |  |  |  |  |  |  |  | (169,366)
Ending Balance at Dec. 31, 2012 | $ (110,679) |  |  |  |  | $ 2,860 | $ 1,991,379 |  |  | $ (6) | $ (2,104,912)
Ending Balance (in shares) at Dec. 31, 2012 |  |  |  |  |  | 286,035,000 |  |  |  |  |

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