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Description of Business and Basis of Presentation - Additional Information (Detail) (USD $)
 1 Months Ended 12 Months Ended 263 Months Ended 12 Months Ended 1 Months Ended
Dec. 31, 2012
Oct. 31, 2007
Dec. 12, 2001
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2002
Dec. 31, 2012
Oct. 31, 2012
Dec. 31, 2009
Oct. 31, 2012
After Amendment
Dec. 31, 2012
Senior convertible notes due December 15, 2013
Dec. 31, 2011
Senior convertible notes due December 15, 2013
Dec. 12, 2006
Senior convertible notes due December 15, 2013
Dec. 31, 2012
Maximum
Dec. 12, 2001
PDC
Dec. 12, 2001
AlleCure
Dec. 12, 2001
CTL
Oct. 31, 2012
Mann Group
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                                      
Deficit accumulated during the development stage $ (2,104,912,000)     $ (2,104,912,000) $ (1,935,546,000)     $ (2,104,912,000)                      
Goodwill impairment             151,400,000 151,428,000                      
Negative cash flow from operation since inception       (119,860,000) (123,837,000) (148,654,000)   (1,596,261,000)                      
Cash and cash equivalents 61,840,000     61,840,000 2,681,000 66,061,000   61,840,000   30,019,000                  
Loan agreement with related party   350,000,000                                  
Promissory note maturity date Jan. 01, 2014                     Dec. 15, 2013              
Borrowing date of promissory note                             Sep. 30, 2013        
Interest rate (LIBOR) 5.00%     5.00%       5.00%                      
Description of variable rate interest annual interest rate on all outstanding principal to the one-year London Interbank Offered Rate (LIBOR) on December 31, 2012 plus 5%, effective January 1, 2013                                    
Sale of aggregate warrant and restricted shares purchase price                                     107,400,000
Amended and restated promissory note outstanding principal amount                                     350,000,000
Loan arrangement principal amount outstanding 119,635,000     119,635,000 277,203,000     119,635,000     119,600,000                
Available borrowing under the amended and restated promissory note 12,750,000     12,750,000 45,000,000     12,750,000 125,400,000                    
Principal amount of convertible senior notes                       115,000,000 115,000,000 115,000,000          
Senior notes, effective interest rate                       3.75%   3.75%          
Percentage of ownership                               76.00% 59.00% 69.00%  
In-process research and development costs     19,700,000         19,726,000                      
Goodwill     $ 151,400,000