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Description of Business and Basis of Presentation - Additional Information (Detail) (USD $)
 1 Months Ended 3 Months Ended 265 Months Ended 3 Months Ended 1 Months Ended
Dec. 31, 2012
Oct. 31, 2012
Mar. 31, 2013
Mar. 31, 2012
Mar. 31, 2013
Jun. 30, 2012
Feb. 28, 2012
Dec. 31, 2011
Mar. 31, 2012
Other Than Equity
Mar. 31, 2013
Maximum
Mar. 31, 2013
Mann Group
Mar. 31, 2012
Mann Group
Forward Purchase Contracts
Mar. 31, 2012
Mann Group
Forward Purchase Contracts
Other Than Equity
Mar. 31, 2013
Mann Group
Forward Purchase Contracts
Equity Component
Dec. 31, 2012
Senior convertible notes due December 15, 2013
Mar. 31, 2013
Senior convertible notes due December 15, 2013
Dec. 12, 2006
Senior convertible notes due December 15, 2013
Mar. 18, 2013
At Market Sales Agreement
Maximum
Mar. 31, 2013
Money market funds
Dec. 31, 2012
Money market funds
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                                        
Deficit accumulated during the development stage $ 2,104,912,000   $ 2,145,877,000   $ 2,145,877,000                              
Goodwill impairment         151,428,000                              
Negative cash flow from operation since inception     (32,027,000) (32,486,000) (1,628,288,000)                              
Cash and cash equivalents 61,840,000   28,005,000 56,355,000 28,005,000     2,681,000                        
Available borrowings under loan agreement     125,400,000   125,400,000                              
Available borrowings date                   Sep. 30, 2013                    
Net proceeds from public offering   86,300,000                                    
Additional gross proceeds from public offering     89,700,000                                  
Aggregate offering price of common stock under agreement                                   50,000,000    
Principal amount of convertible senior notes                             115,000,000 115,000,000 115,000,000      
Promissory note maturity date Jan. 01, 2014                           Dec. 15, 2013          
Senior notes, effective interest rate                             3.75%   3.75%      
Maturity period of cash equivalents     90 days or less at the time of purchase                                  
Cash and cash equivalents 61,800,000   28,000,000   28,000,000                           25,700,000 60,800,000
Capital stock authorized 286,035,082   289,375,250   289,375,250 31,250,000 31,250,000       31,250,000                  
Number of Shares that recorded the portion of the derivative instrument representing equity                           14,700,000            
Number of Shares that recorded the portion of the derivative instrument representing outside of equity                     16,500,000                  
Change in fair value recognized in other income     $ (336,000)   $ (336,000)                              
Risk Free Interest Rate                 0.06%       0.08%              
Discount for lack of marketability       1.64%               2.57%