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Description of Business and Basis of Presentation - Additional Information (Detail) (USD $) | 1 Months Ended | 6 Months Ended | 268 Months Ended |  |  |  |  |  | 1 Months Ended |  | 6 Months Ended |  |  |  |  |  |  | 1 Months Ended |  | 6 Months Ended |  |  |  |  |
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Oct. 31, 2012 | Jun. 30, 2013 | Jun. 30, 2012 | Jun. 30, 2013 | Dec. 31, 2012 | May 17, 2012 | Mar. 31, 2012 | Feb. 28, 2012 | Dec. 31, 2011 | May 17, 2012 Other Than Equity | Mar. 31, 2012 Other Than Equity | Jun. 30, 2013 Maximum | Mar. 18, 2013 Maximum At Market Sales Agreement | Jun. 30, 2013 Mann Group | Oct. 31, 2012 Mann Group | May 17, 2012 Mann Group Forward Purchase Contracts | Mar. 31, 2012 Mann Group Forward Purchase Contracts | Jun. 30, 2013 Mann Group Forward Purchase Contracts Equity Component | May 17, 2012 Mann Group Forward Purchase Contracts Other Than Equity | Mar. 31, 2012 Mann Group Forward Purchase Contracts Other Than Equity | Jun. 30, 2013 Senior convertible notes due December 15, 2013 | Dec. 31, 2012 Senior convertible notes due December 15, 2013 | Dec. 12, 2006 Senior convertible notes due December 15, 2013 | Jul. 01, 2013 Notes 9.75% Due in 2019 First Tranche Subsequent Event | Jul. 01, 2013 Senior Notes Additional First Tranche Subsequent Event | Jun. 30, 2013 Money market funds | Dec. 31, 2012 Money market funds
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deficit accumulated during the development stage |  | $ 2,192,001,000 |  | $ 2,192,001,000 | $ 2,104,912,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Goodwill impairment |  |  |  | 151,428,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Negative cash flow from operation since inception |  | 61,771,000 | 57,504,000 | 1,658,032,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount of convertible senior notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 115,000,000 | 115,000,000 | 115,000,000 |  |  |  |
Promissory note maturity date |  | Jan. 01, 2014 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Dec. 15, 2013 |  |  |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3.75% |  | 3.75% | 9.75% |  |  |
Cash and cash equivalents |  | 28,529,000 | 31,639,000 | 28,529,000 | 61,840,000 |  |  |  | 2,681,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Available borrowings under loan agreement |  | 125,400,000 |  | 125,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Available borrowings date |  |  |  |  |  |  |  |  |  |  |  | Sep. 30, 2013 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants, expiration date | 2013-10 | 2013-10 |  | 2013-10 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from public offering | 86,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds from public offering |  | 89,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from exercise warrants |  | 25,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants remained unexercised |  | 64,600,000 |  | 64,600,000 |  |  |  |  |  |  |  |  |  | 64,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted Stock Agreed to be Purchased by Lender |  |  |  |  |  |  |  | 77,200,000 |  |  |  |  |  | 78,000,000 | 107,400,000 |  |  |  |  |  |  |  |  |  |  |  |
Aggregate offering price of common stock under agreement |  |  |  |  |  |  |  |  |  |  |  |  | 50,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Senior secured notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 40,000,000 | 120,000,000 |  |
Senior notes, Maturity Year |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2019 |  |  |
Maturity period of cash equivalents |  | 90 days or less at the time of purchase |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  | 28,500,000 |  | 28,500,000 | 61,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,900,000 | 60,800,000
Capital stock authorized |  | 300,869,683 | 31,250,000 | 300,869,683 | 286,035,082 |  |  | 31,250,000 |  |  |  |  |  | 31,250,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Number of Shares that recorded the portion of the derivative instrument representing equity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 14,700,000 |  |  |  |  |  |  |  |  |
Number of Shares that recorded the portion of the derivative instrument representing outside of equity |  |  |  |  |  |  |  |  |  |  |  |  |  | 16,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Change in fair value recognized in other income |  |  | $ 12,000,000 |  |  |  | $ (336,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Risk Free Interest Rate |  |  |  |  |  |  |  |  |  | 0.18% | 0.06% |  |  |  |  |  |  |  | 0.08% | 0.08% |  |  |  |  |  |  |
Discount for lack of marketability |  |  |  |  |  | 1.67% | 1.64% |  |  |  |  |  |  |  |  | 10.27% | 2.57% |  |  |  |  |  |  |  |  |  |
Valuation date stock price |  |  |  |  |  |  |  |  |  | $ 1.69 |  |  |  |  |  |  |  |  | $ 2.40 |  |  |  |  |  |  |  |

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