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Consolidated Statements Of Cash Flows (USD $)
In Thousands, unless otherwise specified
 12 Months Ended 275 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2013
CASH FLOWS FROM OPERATING ACTIVITIES:        
Net loss $ (191,490) $ (169,366) $ (160,804) $ (2,296,402)
Adjustments to reconcile net loss to net cash used in operating activities:        
Depreciation and accretion 14,057 14,402 15,912 140,834
Stock-based compensation expense 45,186 13,292 11,204 183,104
Stock expense for shares issued pursuant to research agreement       3,018
Loss (gain) on sale, abandonment/disposal or impairment of property and equipment 817 682 (4) 25,070
Accrued interest on investments, net of amortization of premiums (discounts)       (191)
In-process research and development       19,726
Goodwill impairment       151,428
Loss on available-for-sale securities   117   990
Fair value of forward purchase contract   1,237   1,237
Common shares issued pursuant to litigation settlement   438   438
Commitment to deliver common shares pursuant to litigation settlement   6,056   6,056
Other, net 2 (2) (3) 1,101
Changes in assets and liabilities:        
State research and development credit exchange receivable 466 (290) 830 (297)
Prepaid expenses and other current assets (965) (1,545) 224 (3,535)
Other assets     87 (230)
Accounts payable (1,071) 44 2,672 3,347
Accrued expenses and other current liabilities 3,675 15,075 6,045 38,724
Other liabilities 591     589
Net cash used in operating activities (128,732) (119,860) (123,837) (1,724,993)
CASH FLOWS FROM INVESTING ACTIVITIES:        
Purchase of marketable securities       (796,779)
Sales and maturities of marketable securities     3,828 796,393
Purchase of property and equipment (7,987) (637) (6,858) (335,733)
Proceeds from sale of property and equipment   77 93 454
Net cash used in investing activities (7,987) (560) (2,937) (335,665)
CASH FLOWS FROM FINANCING ACTIVITIES:        
Issuance of common stock and warrants, net of issuance costs 52,421 167,735 10,941 1,450,177
Collection of Series C convertible preferred stock subscriptions receivable       50,000
Issuance of Series B convertible preferred stock for cash       15,000
Cash received for common stock to be issued       3,900
Repurchase of common stock       (1,028)
Put shares sold to majority stockholder       623
Exercise of warrants for common stock 94,147     94,147
Borrowings under lines of credit       4,220
Payment of 2013 notes (115,000)     (115,000)
Proceeds from issuance of facility financing obligation & milestone rights 119,500     119,500
Facility financing obligation & milestone rights issuance costs (598)     (598)
Proceeds from notes receivables       1,742
Borrowings on notes payable to related party   12,750 53,000 387,750
Principal payments on notes payable to our principal stockholder       (70,000)
Borrowings on notes payable       3,460
Principal payments on notes payable to our principal stockholder       (1,667)
Proceeds from senior convertible notes       207,050
Payment of employment taxes related to vested restricted stock units (4,801) (906) (547) (17,828)
Net cash provided by financing activities 145,669 179,579 63,394 2,131,448
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS 8,950 59,159 (63,380) 70,790
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD 61,840 2,681 66,061  
CASH AND CASH EQUIVALENTS, END OF PERIOD 70,790 61,840 2,681 70,790
SUPPLEMENTAL CASH FLOWS DISCLOSURES:        
Cash paid for income taxes       26
Interest paid in cash, net of amounts capitalized to Construction in progress 13,452 9,755 17,248 72,604
Accretion on redeemable convertible preferred stock       (952)
Issuance of common stock upon conversion of notes payable       3,331
Increase in additional paid-in capital resulting from merger       171,154
Issuance of common stock for notes receivable       2,758
Issuance of common stock pursuant to debt conversion by Deerfield 6,500     6,500
Issuance of put option by stockholder       (2,949)
Put option redemption by stockholder       1,921
Issuance of Series C convertible preferred stock subscriptions       50,000
Issuance of Series A redeemable convertible preferred stock       4,296
Conversion of Series A redeemable convertible preferred stock       (5,248)
Non-cash construction in progress and property and equipment 856 4,072 250 856
Capitalization of interest on note payable to related party 7,886 14,219   22,105
Reduction of principal on note payable to related party upon issuance of common stock and exercise of warrants 78,000 184,537 11,116 290,334
Forward purchase contracts contribution to additional paid-in capital   29,317   29,317
Reclassification of forward purchase contracts to additional paid-in capital   $ 28,080   $ 28,080