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Facility Financing Agreement - Additional Information (Detail) (USD $)
 0 Months Ended 12 Months Ended 275 Months Ended 0 Months Ended 12 Months Ended 0 Months Ended 12 Months Ended 12 Months Ended 0 Months Ended 12 Months Ended 0 Months Ended 0 Months Ended
Dec. 20, 2012
Oct. 18, 2012
Dec. 31, 2013
Dec. 31, 2013
Jul. 01, 2013
Registration Rights Agreement
Dec. 31, 2013
Facility Agreement
Maximum
Jul. 01, 2013
Facility Agreement
Maximum
Dec. 31, 2013
Senior convertible notes due December 31 2019
Jul. 01, 2013
Deerfield
Dec. 31, 2013
Deerfield
D
Dec. 31, 2013
Deerfield
Deerfield Conversion price is less than $3.33
Dec. 31, 2013
Deerfield
Deerfield Conversion price exceeds $6.67
Dec. 31, 2013
Deerfield
Deerfield Conversion price between $3.33 and 6.67
Jul. 01, 2013
Deerfield
Fourth Tranche
Dec. 31, 2013
Deerfield
Maximum
Deerfield Conversion price between $3.33 and 6.67
Jul. 01, 2013
Deerfield
Maximum
Milestone Rights Liability
Dec. 31, 2013
Deerfield
Minimum
Dec. 31, 2013
Deerfield
Minimum
Deerfield Conversion price between $3.33 and 6.67
Jul. 01, 2013
Deerfield
Senior convertible notes due December 31 2019
Dec. 31, 2013
Deerfield
Senior convertible notes due December 31 2019
Jul. 01, 2013
Deerfield
Senior convertible notes due December 31 2019
Tranche One
Jul. 01, 2013
Deerfield
Senior convertible notes due December 31 2019
Tranche Two
Jul. 01, 2013
Deerfield
Senior convertible notes due December 31 2019
Milestone Rights Liability
Jul. 01, 2013
Deerfield
Senior convertible notes due December 31 2019
Notes Issued in Four Equal Tranches
Jul. 01, 2013
Deerfield
Senior convertible notes due December 31 2019
Tranche Three
Debt Instrument [Line Items]                                                  
Facility Agreement, annual principal payment     $ 28,375,000                                            
Facility Agreement, total principal payment     113,500,000 113,500,000                                          
Facility Agreement, payment commencing date     Jul. 01, 2016                                            
Facility Agreement, payment ending date     Dec. 09, 2019                                            
Debt facility principal amount               120,000,000                         40,000,000 40,000,000   160,000,000 40,000,000
Debt facility periodic principal amount                                               40,000,000  
Interest rate                                               9.75%  
Repayment as a percentage of original principal amount                                     25.00%            
Debt instrument maturity date                                     Dec. 31, 2019            
Maximum available amount of credit facility under covenant restrictions           25,000,000 25,000,000                                    
Value received, from Tranche 1 Notes and Milestone Rights                                     52,900,000            
Proceeds from debt issuance     119,500,000 119,500,000                                 39,500,000        
Commitment asset at fair value                                     13,400,000            
Estimated fair values debt issued               107,000,000                         37,100,000   16,300,000    
Effective interest rate                                         12.19% 12.45%     13.49%
Debt discount                                         3,300,000 3,700,000     5,000,000
Payment for debt issue costs     598,000 598,000         500,000                   448,737            
Debt issuance costs                 597,529         128,008         536,266            
Contingent liability for milestone payments                               90,000,000                  
Short term liability                                             3,200,000    
Long term liability     102,300,000 102,300,000       102,300,000                             13,100,000    
Discount rate 1.50% 2.30%                                         17.50%    
Risk premium                                             5.00%    
Share registration statement shares of common stock to be registered         12,000,000                                        
Additional damage calculation percentage                                       1.00%          
Number of trading days                   20                              
Percentage of beneficial ownership                                 9.985%                
Common shares issued upon conversion                     12,000,000 6,000,000               1,293,224          
Common shares issued upon conversion per share price                     $ 3.33 $ 6.67     $ 6.67     $ 3.33              
Amount of common shares issued upon conversion       3,331,000                 40,000,000             6,500,000          
Notification in number of days                   20 days                              
Number of business days                   2                              
Facility arrangement amount to be paid in excess of legal judgment                   $ 100,000