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Subsequent Event - Additional Information (Detail) (USD $)
12 Months Ended 275 Months Ended 12 Months Ended 0 Months Ended 12 Months Ended 0 Months Ended 1 Months Ended 0 Months Ended 0 Months Ended
Dec. 31, 2013
Dec. 31, 2013
Mar. 18, 2013
At-the-Market Issuance Sales Agreement
Maximum
Dec. 31, 2013
Deerfield
D
Dec. 31, 2013
Senior convertible notes due December 31 2019
Jul. 01, 2013
Senior convertible notes due December 31 2019
Deerfield
Dec. 31, 2013
Senior convertible notes due December 31 2019
Deerfield
Jul. 01, 2013
Senior convertible notes due December 31 2019
Deerfield
Tranche Two
Jul. 01, 2013
Senior convertible notes due December 31 2019
Deerfield
Notes Issued in Four Equal Tranches
Mar. 03, 2014
Subsequent Event
At-the-Market Issuance Sales Agreement
Maximum
Feb. 28, 2014
Subsequent Event
Senior convertible notes due December 31 2019
Deerfield
Jan. 31, 2014
Subsequent Event
Senior convertible notes due December 31 2019
Deerfield
Jan. 31, 2014
Subsequent Event
Senior convertible notes due December 31 2019
Deerfield
Tranche Two
Feb. 28, 2014
Subsequent Event
Senior convertible notes due December 31 2019
Deerfield
Tranche B notes
Feb. 28, 2014
Subsequent Event
Senior convertible notes due December 31 2019
Deerfield
Tranche B notes
Maximum
Feb. 28, 2014
Subsequent Event
Senior convertible notes due December 31 2019
Deerfield
Tranche B notes
Minimum
Feb. 28, 2014
Subsequent Event
Senior convertible notes due December 31 2019
Deerfield
Fourth Tranche
Feb. 28, 2014
Subsequent Event
Senior convertible notes due December 31 2019
Deerfield
Notes Issued in Four Equal Tranches
D
Subsequent Event [Line Items]                                    
Amount of common shares issued upon conversion   $ 3,331,000         $ 6,500,000         $ 33,500,000            
Common shares issued upon conversion             1,293,224         6,559,251 7,852,475         12,000,000
Amount of common shares issued upon conversion 6,500,000 6,500,000                 20,000,000   40,000,000 0     90,000,000 60,000,000
Debt facility principal amount         120,000,000     40,000,000 160,000,000           0      
Principal amount Percentage conversion of debt into common stock                     33.30%           150.00%  
Interest rate                 9.75%           9.75% 8.75%    
Due date of the notes issued           Dec. 31, 2019               Dec. 31, 2019        
Common shares issued upon conversion per share price                                   $ 5.00
Debt facility, convertible threshold trading days       20                           3
Aggregate offering price of common stock under agreement     $ 50,000,000             $ 50,000,000                
Repayment as a percentage of original principal amount           25.00%