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Description of Business and Basis of Presentation - Additional Information (Detail) (USD $)
 277 Months Ended 0 Months Ended 0 Months Ended
Mar. 31, 2014
Dec. 31, 2013
Mar. 31, 2013
Dec. 31, 2012
Mar. 31, 2014
Senior convertible notes due December 31, 2019
Dec. 31, 2013
Senior convertible notes due December 31, 2019
Mar. 31, 2014
Senior convertible notes due December 31, 2019
Deerfield
Mar. 31, 2014
Senior convertible notes due December 31, 2019
Deerfield
Facility Agreement
Maximum
Jun. 30, 2013
Senior convertible notes due December 31, 2019
Deerfield
Notes Issued in Four Equal Tranches
Tranche
Mar. 31, 2014
Senior convertible notes due December 31, 2019
Deerfield
Notes Issued in Four Equal Tranches
Feb. 28, 2014
Senior convertible notes due December 31, 2019
Deerfield
Tranche B notes
Scenario 1
Feb. 28, 2014
Senior convertible notes due December 31, 2019
Deerfield
Tranche B notes
Scenario 2
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Deficit accumulated during the development stage $ 2,348,458,000 $ 2,296,402,000                    
Goodwill impairment 151,428,000                      
Cash flow from operation since inception (1,761,983,000)                      
Cash and cash equivalents 35,759,000 70,790,000 28,005,000 61,840,000                
Available borrowings under loan agreement 30,100,000                      
Accrued interest on loan arrangement 1,300,000                      
Debt facility principal amount         120,000,000       160,000,000 120,000,000 90,000,000 20,000,000
Number of equal tranches                 4      
Debt facility periodic principal amount                 40,000,000      
Debt facility carrying amount         25,900,000 102,300,000 40,000,000     40,000,000    
Percentage of principal amount converted in to common stock                     150.00% 33.33%
Maximum available amount of credit facility under covenant restrictions               $ 25,000,000