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Description of Business and Basis of Presentation - Additional Information (Detail) (USD $) | 280 Months Ended |  |  |  |  | 0 Months Ended |  |  | 6 Months Ended |  |  | 0 Months Ended |  | 0 Months Ended |
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Jun. 30, 2014 | Dec. 31, 2013 | Jun. 30, 2013 | Dec. 31, 2012 | Jun. 30, 2014 Senior convertible notes due December 31, 2019 Deerfield | Jun. 30, 2014 Senior convertible notes due December 31, 2019 Deerfield Facility Agreement Maximum | Jul. 01, 2013 Senior convertible notes due December 31, 2019 Deerfield Notes Issued in Four Equal Tranches Tranche | Jun. 30, 2014 Senior convertible notes due December 31, 2019 Deerfield Notes Issued in Four Equal Tranches | Jul. 01, 2013 Senior convertible notes due December 31, 2019 Deerfield Notes Issued in Four Equal Tranches | Jun. 30, 2014 Senior convertible notes due December 31, 2019 Deerfield Tranche B notes | May 06, 2014 Senior convertible notes due December 31, 2019 Deerfield Tranche B notes | Feb. 28, 2014 Senior convertible notes due December 31, 2019 Deerfield Tranche B notes | Aug. 11, 2014 Subsequent Event License and Collaboration Agreement with Sanofi | Aug. 11, 2014 Subsequent Event License and Collaboration Agreement with Sanofi | Aug. 11, 2014 Subsequent Event License and Collaboration Agreement with Sanofi Second Amendment Facility Agreement | Aug. 11, 2014 Subsequent Event License and Collaboration Agreement with Sanofi Sanofi-Aventis Deutschland GmbH | Jul. 18, 2014 Subsequent Event Senior convertible notes due December 31, 2019 Deerfield Fourth tranche
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deficit accumulated during the development stage | $ 2,421,824,000 | $ 2,296,402,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Goodwill impairment | 151,428,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash flow from operation since inception | (1,800,000,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents | 41,214,000 | 70,790,000 | 28,529,000 | 61,840,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Available borrowings under loan agreement | 30,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued interest on loan arrangement | 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt facility principal amount |  |  |  |  |  |  |  | 120,000,000 | 160,000,000 |  |  | 90,000,000 |  |  |  |  |
Number of equal tranches |  |  |  |  |  |  | 4 |  |  |  |  |  |  |  |  |  |
Debt facility periodic principal amount |  |  |  |  |  |  |  |  | 40,000,000 |  |  |  |  |  |  |  |
Debt facility carrying amount |  |  |  |  | 40,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Principal amount of notes purchased |  |  |  |  |  |  |  |  |  |  | 20,000,000 |  |  |  |  |  | 40,000,000
Maximum available amount of credit facility under covenant restrictions |  |  |  |  |  | 25,000,000 |  |  |  |  |  |  |  |  |  |  |
Additional sales of notes | 119,500,000 |  |  |  |  |  |  |  |  | 70,000,000 |  |  |  |  |  |  |
Upfront fee |  |  |  |  |  |  |  |  |  |  |  |  | 150,000,000 |  |  |  |
Potential milestone payment |  |  |  |  |  |  |  |  |  |  |  |  |  | 775,000,000 |  |  |
Profits and losses sharing percentage |  |  |  |  |  |  |  |  |  |  |  |  | 35.00% |  |  | 65.00% |
Maximum secured loan facility |  |  |  |  |  |  |  |  | $ 160,000,000 |  |  |  |  |  | $ 175,000,000 |  |

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