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Description of Business and Basis of Presentation - Additional Information (Detail) (USD $)	280 Months Ended						0 Months Ended			6 Months Ended			0 Months Ended			0 Months Ended
	Jun. 30, 2014	Dec. 31, 2013	Jun. 30, 2013	Dec. 31, 2012	Jun. 30, 2014 Senior convertible notes due December 31, 2019 Deerfield	Jun. 30, 2014 Senior convertible notes due December 31, 2019 Deerfield Facility Agreement Maximum	Jul. 01, 2013 Senior convertible notes due December 31, 2019 Deerfield Notes Issued in Four Equal Tranches Tranche	Jun. 30, 2014 Senior convertible notes due December 31, 2019 Deerfield Notes Issued in Four Equal Tranches	Jul. 01, 2013 Senior convertible notes due December 31, 2019 Deerfield Notes Issued in Four Equal Tranches	Jun. 30, 2014 Senior convertible notes due December 31, 2019 Deerfield Tranche B notes	May 06, 2014 Senior convertible notes due December 31, 2019 Deerfield Tranche B notes	Feb. 28, 2014 Senior convertible notes due December 31, 2019 Deerfield Tranche B notes	Aug. 11, 2014 Subsequent Event License and Collaboration Agreement with Sanofi	Aug. 11, 2014 Subsequent Event License and Collaboration Agreement with Sanofi	Aug. 11, 2014 Subsequent Event License and Collaboration Agreement with Sanofi Second Amendment Facility Agreement	Aug. 11, 2014 Subsequent Event License and Collaboration Agreement with Sanofi Sanofi-Aventis Deutschland GmbH	Jul. 18, 2014 Subsequent Event Senior convertible notes due December 31, 2019 Deerfield Fourth tranche
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Deficit accumulated during the development stage	$ 2,421,824,000	$ 2,296,402,000
Goodwill impairment	151,428,000
Cash flow from operation since inception	(1,800,000,000)
Cash and cash equivalents	41,214,000	70,790,000	28,529,000	61,840,000
Available borrowings under loan agreement	30,100,000
Accrued interest on loan arrangement	2,000,000
Debt facility principal amount								120,000,000	160,000,000			90,000,000
Number of equal tranches							4
Debt facility periodic principal amount									40,000,000
Debt facility carrying amount					40,000,000
Principal amount of notes purchased											20,000,000						40,000,000
Maximum available amount of credit facility under covenant restrictions						25,000,000
Additional sales of notes	119,500,000									70,000,000
Upfront fee													150,000,000
Potential milestone payment														775,000,000
Profits and losses sharing percentage													35.00%			65.00%
Maximum secured loan facility									$ 160,000,000						$ 175,000,000

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