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Condensed Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified | 9 Months Ended | 283 Months Ended
--- | --- | ---
Sep. 30, 2014 | Sep. 30, 2013 | Sep. 30, 2014
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
Net loss | $ (161,941) | $ (137,907) | $ (2,458,343)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation and accretion | 15,574 | 10,109 | 156,408
Stock-based compensation expense | 46,755 | 31,304 | 229,859
Stock expense for shares issued pursuant to research agreement |  |  | 3,018
(Gain) loss on sale, abandonment/disposal or impairment of property and equipment |  | 686 | 25,070
Accrued interest on investments, net of amortization of discounts |  |  | (191)
In-process research and development |  |  | 19,726
Goodwill impairment |  |  | 151,428
Loss on available-for-sale securities |  |  | 990
Write-off of derivative liability | (363) |  | (363)
Litigation settlement in stock |  |  | 6,494
Fair value of forward purchase contract |  |  | 1,237
Interest expense related to milestone payment | 1,850 |  | 1,850
Other, net | (7) | (3) | 1,094
Changes in assets and liabilities: |  |  |
State research and development credit exchange receivable | (765) | 242 | (1,062)
Prepaid expenses and other current assets | (14,768) | (708) | (18,303)
Other assets | (130) |  | (360)
Accounts payable | 13,692 | (1,929) | 17,039
Accrued expenses and other current liabilities | (3,003) | 3,525 | 35,721
Deferred up-front payment from collaboration agreement | 150,000 |  | 150,000
Other liabilities | 2,186 |  | 2,775
Net cash provided by (used in) operating activities | 39,830 | (94,681) | (1,685,163)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Purchase of marketable securities |  |  | (796,779)
Sales and maturities of marketable securities |  |  | 796,393
Purchase of property and equipment | (19,134) | (1,821) | (354,867)
Proceeds from sale of property and equipment |  |  | 454
Net cash used in investing activities | (9,884) | (1,821) | (345,549)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Issuance of common stock and warrants, net of issuance costs | 38,573 | 51,658 | 1,582,897
Collection of Series C convertible preferred stock subscriptions receivable |  |  | 50,000
Issuance of Series B convertible preferred stock for cash |  |  | 15,000
Cash received for common stock to be issued |  |  | 3,900
Repurchase of common stock |  |  | (1,028)
Put shares sold to majority stockholder |  |  | 623
Borrowings under lines of credit |  |  | 4,220
Payment of 2013 notes |  |  | (115,000)
Proceeds from notes receivables |  |  | 1,742
Proceeds from issuance of facility financing obligation & milestone rights | 40,000 | 79,500 | 159,500
Proceeds from issuance of Tranche B of the facility financing obligation | 20,000 |  | 20,000
Facility financing obligation & milestone rights issuance costs |  | (598) | (598)
Borrowings on notes payable to principal stockholder |  |  | 387,750
Principal payments on notes payable to principal stockholder |  |  | (70,000)
Borrowings on notes payable |  |  | 3,460
Principal payments on notes payable |  |  | (1,667)
Proceeds from senior convertible notes |  |  | 207,050
Payment of employment taxes related to vested restricted stock units | (26,844) | (2,095) | (44,672)
Net cash provided by financing activities | 71,729 | 128,465 | 2,203,177
NET INCREASE IN CASH AND CASH EQUIVALENTS | 101,675 | 31,963 | 172,465
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD | 70,790 | 61,840 |
CASH AND CASH EQUIVALENTS, END OF PERIOD | 172,465 | 93,803 | 172,465
SUPPLEMENTAL CASH FLOWS DISCLOSURES: |  |  |
Cash paid for income taxes |  |  | 26
Interest paid in cash, net of amounts capitalized | 9,740 | 7,862 | 82,344
Accretion on redeemable convertible preferred stock |  |  | (952)
Issuance of common stock upon conversion of notes payable |  |  | 3,331
Increase in additional paid-in capital resulting from merger |  |  | 171,154
Issuance of common stock for notes receivable |  |  | 2,758
Issuance of common stock pursuant to conversion of facility financing obligation | 93,500 |  | 100,000
Issuance of put option by stockholder |  |  | (2,949)
Put option redemption by stockholder |  |  | 1,921
Issuance of Series C convertible preferred stock subscriptions |  |  | 50,000
Issuance of Series A redeemable convertible preferred stock |  |  | 4,296
Conversion of Series A redeemable convertible preferred stock |  |  | (5,248)
Non-cash construction in progress and property and equipment | 3,809 | 5,523 | 3,089
Capitalization of interest on note payable to principal stockholder |  |  | 22,105
Reduction of principal on note payable to principal stockholder upon issuance of common stock and exercise of warrants |  |  | 290,334
Forward purchase contract contribution to APIC |  |  | 29,317
Reclassification of forward purchase contract to APIC |  |  | 28,080
Reclassification of share-based awards to liability | 22,963 |  | 22,963
Tranche B Commitment Asset | 1,753 |  | 1,753
Intellectual property |  |  |
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Income from sale of intellectual property | (9,250) |  | (9,250)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Proceeds from sale of intellectual property | $ 9,250 |  | $ 9,250

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 + Details
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- Definition The fair value of stock issued in noncash financing activities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4313-108586 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 + Details
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- Definition Amount of decrease to net income for accretion of temporary equity to its redemption value to derive net income apportioned to common stockholders. + References No definition available. + Details
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- Definition The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of derivative instruments, including options, swaps, futures, and forward contracts, held at each balance sheet date, that was included in earnings for the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 + Details
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