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Description of Business and Basis of Presentation - Additional Information (Detail) | 0 Months Ended | 9 Months Ended | 283 Months Ended |  |  |  | 0 Months Ended | 3 Months Ended |  |  | 0 Months Ended |  | 9 Months Ended |  |  | 0 Months Ended | 9 Months Ended |  |
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Jul. 18, 2014 USD ($) | Sep. 30, 2014 USD ($) | Sep. 30, 2013 USD ($) | Sep. 30, 2014 USD ($) | Jul. 31, 2014 EUR (€) | Dec. 31, 2013 USD ($) | Dec. 31, 2012 USD ($) | Aug. 11, 2014 License and Collaboration Agreement with Sanofi | Sep. 30, 2014 License and Collaboration Agreement with Sanofi USD ($) | Sep. 23, 2014 License and Collaboration Agreement with Sanofi USD ($) | Aug. 11, 2014 License and Collaboration Agreement with Sanofi USD ($) | Aug. 11, 2014 License and Collaboration Agreement with Sanofi Second Amendment Facility Agreement USD ($) | Aug. 11, 2014 License and Collaboration Agreement with Sanofi Sanofi-Aventis Deutschland GmbH | Sep. 30, 2014 Maximum ATM Agreements USD ($) | Sep. 30, 2014 Senior convertible notes due August 15, 2015 USD ($) | Dec. 31, 2013 Senior convertible notes due August 15, 2015 USD ($) | Aug. 18, 2010 Senior convertible notes due August 15, 2015 USD ($) | Feb. 28, 2014 Senior convertible notes due December 31, 2019 Deerfield Tranche B notes | Sep. 30, 2014 Senior convertible notes due December 31, 2019 Deerfield Tranche B notes USD ($) | Sep. 23, 2014 Senior convertible notes due December 31, 2019 Deerfield Tranche B notes USD ($) | Feb. 28, 2014 Senior convertible notes due December 31, 2019 Deerfield Tranche B notes USD ($)
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deficit accumulated during the development stage |  | $ 2,458,343,000 |  | $ 2,458,343,000 |  | $ 2,296,402,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Goodwill impairment |  |  |  | 151,428,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash flow from operation since inception |  |  |  | 1,700,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  | 172,465,000 | 93,803,000 | 172,465,000 |  | 70,790,000 | 61,840,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt facility principal amount |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000,000 | 100,000,000 | 100,000,000 |  |  |  | 90,000,000
Senior notes, effective interest rate |  |  |  |  |  |  |  |  |  | 8.50% |  |  |  |  | 5.75% |  | 5.75% |  |  | 8.75% | 9.75%
Debt instrument maturity date |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Aug. 15, 2015 |  |  | Dec. 31, 2019 |  |  |
Available borrowings under loan agreement |  | 30,100,000 |  | 30,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential proceeds from the exercise of warrants from February 2012 public offering |  | 20,000,000 |  | 20,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offering price of common stock under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  | 50,000,000 |  |  |  |  |  |  |
Additional sales of notes |  | 40,000,000 | 79,500,000 | 159,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 70,000,000 |  |
Up-front fee |  |  |  |  |  |  |  |  | 150,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment |  |  |  |  |  |  |  |  |  |  | 775,000,000 |  |  |  |  |  |  |  |  |  |
Profits and losses sharing percentage |  |  |  |  |  |  |  | 35.00% |  |  |  |  | 65.00% |  |  |  |  |  |  |  |
Maximum secured loan facility |  |  |  |  |  |  |  |  |  | 175,000,000 |  | 175,000,000 |  |  |  |  |  |  |  | 175,000,000 |
Prepaid expenses and other current assets |  | 20,253,000 |  | 20,253,000 |  | 5,485,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Prepayment of prepaid insurance, and prepaid clinical trial expenses |  | 15,000,000 |  | 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Remaining minimum amount committed in calendar years 2015 through 2019 |  |  |  |  | 120,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Supply Agreement expiration period | Dec. 31, 2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Supply Agreement renewal period | 2 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Consideration received | 9,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offset expense associated with intellectual property | $ 1,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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