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Stock award plans (Tables) | 12 Months Ended
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Dec. 31, 2014
Stock Based Award Plans | The following table summarizes information about the Company’s stock-based award plans as of December 31, 2014:
|  | Outstanding Options |  |  | Outstanding Restricted Stock Units |  |  | Shares Available for Future Issuance |
2004 Equity Incentive Plan |  |  | 13,629,994 |  |  |  | 1,219,915 |  |  |  | — |
2013 Equity Incentive Plan |  |  | 7,380,839 |  |  |  | 1,390,805 |  |  |  | 15,506,488 |
2004 Non-Employee Directors’ Stock Option Plan |  |  | 530,831 |  |  |  | — |  |  |  | — |
Total |  |  | 21,541,664 |  |  |  | 2,610,720 |  |  |  | 15,506,488 |
Stock Based Compensation Expense Recognized in Accompanying Statements of Operations | Total stock-based compensation expense recognized in the accompanying statements of operations is as follows (in thousands):
|  | Year Ended December 31, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
Employee-related |  | $ | 48,622 |  |  | $ | 45,181 |  |  | $ | 13,224 |
Consultant-related |  |  | — |  |  |  | 5 |  |  |  | 68 |
Total |  | $ | 48,622 |  |  | $ | 45,186 |  |  | $ | 13,292 |
Stock Based Compensation Expense Recognized in Accompanying Statements of Operations by Category | Total stock-based compensation expense recognized in the accompanying statements of operations is included in the following categories (in thousands):
|  | Year Ended December 31, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
Research and development |  | $ | 22,357 |  |  | $ | 20,409 |  |  | $ | 6,167 |
General and administrative |  |  | 26,265 |  |  |  | 24,777 |  |  |  | 7,125 |
Total |  | $ | 48,622 |  |  | $ | 45,186 |  |  | $ | 13,292 |
Assumptions Used to Calculate Fair Value of Employee Stock Options | The Company calculated the fair value of employee stock options granted during the years ended December 31, 2014, 2013 and 2012 using the following assumptions:
|  | Year Ended December 31, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
Risk-free interest rate |  |  | 1.64% — 2.11% |  |  |  | 0.94% — 1.82% |  |  |  | 0.32% —1.16% |
Expected lives |  |  | 5.77 — 6.09 years |  |  |  | 2.64 — 5.77 years |  |  |  | 1.4 — 6.1 years |
Volatility |  |  | 73.98% — 84.85% |  |  |  | 75.83% — 86.26% |  |  |  | 70% — 84% |
Dividends |  |  | — |  |  |  | — |  |  |  | — |
Summary of Stock Options Outstanding | The following table summarizes information about stock options outstanding:
|  | Number of Shares |  |  | Weighted Average Exercise Price per Share |  |  | Aggregate Intrinsic Value ($000) |
Outstanding at January 1, 2014 |  |  | 24,237,940 |  |  |  | 4.35 |  |  | $ | 40,972 |
Granted |  |  | 1,326,800 |  |  |  | 7.21 |  |  |  |  |
Exercised |  |  | (3,250,149 | ) |  |  | 3.37 |  |  |  |  |
Forfeit |  |  | (417,223 | ) |  |  | 4.54 |  |  |  |  |
Expired |  |  | (355,704 | ) |  |  | 12.48 |  |  |  |  |
Outstanding at December 31, 2014 |  |  | 21,541,664 |  |  |  | 4.53 |  |  | $ | 33,495 |
Vested and expected to vest at December 31, 2014 |  |  | 21,307,827 |  |  |  | 4.52 |  |  | $ | 33,253 |
Exercisable at December 31, 2014 |  |  | 18,439,472 |  |  |  | 4.42 |  |  | $ | 30,356 |
Summary of Restricted Stock Unit Activity | A summary of restricted stock unit activity for the year ended December 31, 2014 is presented below:
|  | Number of Shares |  |  | Weighted Average Grant Date Fair Value per Share |
Outstanding at January 1, 2014 |  |  | 9,115,821 |  |  | $ | 3.90 |
Granted |  |  | 954,127 |  |  | $ | 7.14 |
Vested |  |  | (6,982,707 | ) |  | $ | 3.83 |
Forfeited |  |  | (476,521 | ) |  | $ | 4.30 |
Outstanding at December 31, 2014 |  |  | 2,610,720 |  |  | $ | 5.20 |

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- Definition Tabular disclosure of components of a stock option or other award plan under which equity-based compensation is awarded to employees, typically comprised of the amount of unearned compensation (deferred compensation cost), compensation expense, and changes in the quantity and fair value of the shares (or other type of equity) granted, exercised, forfeited, and issued and outstanding pertaining to that plan. Disclosure may also include nature and general terms of such arrangements that existed during the period and potential effects of those arrangements on shareholders, effect of compensation cost arising from equity-based payment arrangements on the income statement, method of estimating the fair value of the goods or services received, or the fair value of the equity instruments granted, during the period, cash flow effects resulting from equity-based payment arrangements and, for registrants that accelerate vesting of out of the money share options, reasons for the decision to accelerate. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of share-based compensation plans that may be presented in a single table for outstanding, vested and expected to vest, and exercisable awards. The information that may be disclosed in this table may include, but is not limited to, number of shares, weighted average exercise price, weighted average remaining contractual life, and aggregate intrinsic value. + References No definition available. + Details
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- Definition Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year. + References No definition available. + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of employee stock purchase plans, including, but not limited to: (a) expected term, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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