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Consolidated Balance Sheets (USD $)
In Thousands, unless otherwise specified
Dec. 31, 2014
Dec. 31, 2013
Current assets:    
Cash and cash equivalents $ 120,841us-gaap_CashAndCashEquivalentsAtCarryingValue $ 70,790us-gaap_CashAndCashEquivalentsAtCarryingValue
Receivables from collaboration 50,436us-gaap_AccountsReceivableNetCurrent  
Inventory 9,670us-gaap_InventoryNet  
Prepaid expenses and other current assets 20,206us-gaap_PrepaidExpenseAndOtherAssetsCurrent 5,485us-gaap_PrepaidExpenseAndOtherAssetsCurrent
Total current assets 201,153us-gaap_AssetsCurrent 76,275us-gaap_AssetsCurrent
Property and equipment - net 192,127us-gaap_PropertyPlantAndEquipmentNet 176,557us-gaap_PropertyPlantAndEquipmentNet
State research and development credit exchange receivable - net of current portion 311us-gaap_NontradeReceivablesNoncurrent 298us-gaap_NontradeReceivablesNoncurrent
Other assets 848us-gaap_OtherAssetsNoncurrent 5,516us-gaap_OtherAssetsNoncurrent
Total 394,439us-gaap_Assets 258,646us-gaap_Assets
Current liabilities:    
Accounts payable 7,394us-gaap_AccountsPayableCurrent 3,860us-gaap_AccountsPayableCurrent
Accrued expenses and other current liabilities 26,206us-gaap_AccruedLiabilitiesCurrent 21,634us-gaap_AccruedLiabilitiesCurrent
Facility financing obligation 72,995us-gaap_OtherLongTermDebtCurrent 102,300us-gaap_OtherLongTermDebtCurrent
Senior convertible notes 99,355us-gaap_ConvertibleNotesPayableCurrent  
Deferred payments from collaboration 197,403us-gaap_DeferredRevenueCurrent  
Total current liabilities 403,353us-gaap_LiabilitiesCurrent 127,794us-gaap_LiabilitiesCurrent
Senior convertible notes   98,439us-gaap_ConvertibleLongTermNotesPayable
Note payable to principal stockholder 49,521us-gaap_NotesPayableRelatedPartiesNoncurrent 49,521us-gaap_NotesPayableRelatedPartiesNoncurrent
Other liabilities 15,335us-gaap_OtherLiabilitiesNoncurrent 13,605us-gaap_OtherLiabilitiesNoncurrent
Total liabilities 468,209us-gaap_Liabilities 289,359us-gaap_Liabilities
Commitments and contingencies      
Stockholders' deficit:    
Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at December 31, 2014 and 2013      
Common stock, $0.01 par value - 550,000,000 shares authorized at December 31, 2014 and 2013, respectively; 406,059,089 and 369,391,972 shares issued and outstanding at December 31, 2014 and 2013, respectively 4,061us-gaap_CommonStockValue 3,697us-gaap_CommonStockValue
Additional paid-in capital 2,416,967us-gaap_AdditionalPaidInCapitalCommonStock 2,261,996us-gaap_AdditionalPaidInCapitalCommonStock
Accumulated other comprehensive income (loss) (14)us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax (4)us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax
Accumulated deficit (2,494,784)us-gaap_RetainedEarningsAccumulatedDeficit (2,296,402)us-gaap_RetainedEarningsAccumulatedDeficit
Total stockholders' deficit (73,770)us-gaap_StockholdersEquity (30,713)us-gaap_StockholdersEquity
Total $ 394,439us-gaap_LiabilitiesAndStockholdersEquity $ 258,646us-gaap_LiabilitiesAndStockholdersEquity