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Potential Milestone Payments

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- Definition

Potential Proceeds from Warrant Exercises

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Profit Loss Sharing Agreement Allocation Percentage

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Upfront Fee

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Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation.

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Face (par) amount of debt instrument at time of issuance.

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-Topic 835

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Contractual interest rate for funds borrowed, under the debt agreement.

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Date when the debt instrument is scheduled to be fully repaid, in CCYY-MM-DD format.

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Maximum borrowing capacity under the credit facility without consideration of any current restrictions on the amount that could be borrowed or the amounts currently outstanding under the facility.

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Amount of borrowing capacity currently available under the credit facility (current borrowing capacity less the amount of borrowings outstanding).

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The cumulative amount of the reporting entity's undistributed earnings or deficit.

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The amount of consideration recognized during the period for the milestone or milestones.

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Description of Business and Basis of Presentation - Additional Information (Detail) (USD $)	12 Months Ended	0 Months Ended		3 Months Ended
	Dec. 31, 2014	Feb. 28, 2014	Aug. 11, 2014	Sep. 30, 2014	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Aug. 18, 2010	Dec. 30, 2014	Sep. 23, 2014
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Accumulated deficit	$ (2,494,784,000)				$ (2,296,402,000)
Cash and cash equivalents	120,841,000				70,790,000	61,840,000	2,681,000
Amount available for future borrowings	30,100,000
Potential proceeds from the exercise of warrants from February 2012 public offering	19,500,000
Maximum \| ATM Agreements
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Offering price of common stock under agreement	50,000,000
Senior convertible notes due August 15, 2015
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Senior notes, effective interest rate	5.75%							5.75%
Debt facility principal amount	100,000,000				100,000,000			100,000,000
Debt instrument maturity date	Aug. 15, 2015
Senior convertible notes due December 31, 2019 \| Maximum \| Less portion of commitment asset
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Amount available for future borrowings									70,000,000
Deerfield \| Senior convertible notes due December 31, 2019
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Senior notes, effective interest rate	975.00%
Debt facility principal amount	60,000,000
Deerfield \| Senior convertible notes due December 31, 2019 \| Less portion of commitment asset
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Senior notes, effective interest rate	875.00%	9.75%
Debt facility principal amount	20,000,000
Debt instrument maturity date		Dec. 31, 2019
Maximum secured loan facility										175,000,000
Deerfield \| Senior convertible notes due December 31, 2019 \| Maximum \| Less portion of commitment asset
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Debt facility principal amount		90,000,000
Deerfield \| Senior convertible notes due December 31, 2019 \| Minimum \| Facility Agreement \| Less portion of commitment asset
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Available amount of credit facility under covenant restrictions	25,000,000
License and Collaboration Agreement with Sanofi
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Senior notes, effective interest rate										8.50%
Up-front fee				150,000,000
Potential milestone payment	725,000,000		775,000,000
Profits and losses sharing percentage	35.00%		35.00%
Maximum secured loan facility										175,000,000
License and Collaboration Agreement with Sanofi \| Sanofi-Aventis Deutschland GmbH
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Profits and losses sharing percentage	65.00%		65.00%
Maximum secured loan facility	175,000,000
License and Collaboration Agreement with Sanofi \| Development and Manufacturing Milestone Events
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Milestone payments earned	50,000,000
Potential milestone payment			$ 75,000,000