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Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Revenue			$ 35us-gaap_SalesRevenueNet
Operating expenses:
Research and development	100,244us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost	109,719us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost	101,522us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost
General and administrative	79,383us-gaap_GeneralAndAdministrativeExpense	59,682us-gaap_GeneralAndAdministrativeExpense	45,473us-gaap_GeneralAndAdministrativeExpense
Total operating expenses	179,627us-gaap_OperatingExpenses	169,401us-gaap_OperatingExpenses	146,995us-gaap_OperatingExpenses
Loss from operations	(179,627)us-gaap_OperatingIncomeLoss	(169,401)us-gaap_OperatingIncomeLoss	(146,960)us-gaap_OperatingIncomeLoss
Other income (expense)	1,679us-gaap_OtherNonoperatingIncomeExpense	(635)us-gaap_OtherNonoperatingIncomeExpense	(1,191)us-gaap_OtherNonoperatingIncomeExpense
Interest expense on note payable to principal stockholder	(2,894)us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty	(6,309)us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty	(10,491)us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty
Interest expense on notes	(17,549)us-gaap_InterestExpenseDebt	(15,153)us-gaap_InterestExpenseDebt	(11,139)us-gaap_InterestExpenseDebt
Interest income	9us-gaap_InvestmentIncomeInterest	8us-gaap_InvestmentIncomeInterest	7us-gaap_InvestmentIncomeInterest
Loss before benefit for income taxes	(198,382)us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	(191,490)us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	(169,774)us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
Income tax benefit			408us-gaap_IncomeTaxExpenseBenefit
Net loss	$ (198,382)us-gaap_NetIncomeLoss	$ (191,490)us-gaap_NetIncomeLoss	$ (169,366)us-gaap_NetIncomeLoss
Net loss per share - basic and diluted	$ (0.51)us-gaap_EarningsPerShareBasicAndDiluted	$ (0.64)us-gaap_EarningsPerShareBasicAndDiluted	$ (0.94)us-gaap_EarningsPerShareBasicAndDiluted
Shares used to compute basic and diluted net loss per share	385,229us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	299,591us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	180,855us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted

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The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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