Consolidated Statements of Stockholders' (Deficit) (USD $) In Thousands, except Share data	Total	Common Stock	Additional Paid-in Capital	Other Comprehensive Income (Loss)	Deficit Accumulated During the Development Stage
Beginning Balance at Dec. 31, 2011	$ (313,652)us-gaap_StockholdersEquity	$ 1,315	$ 1,620,535	$ 44	$ (1,935,546)
Beginning Balance (in shares) at Dec. 31, 2011		131,523,000
Exercise of stock options (in shares)		3,000
Exercise of stock options	9		9
Issuance of common shares from the release of restricted stock units (in shares)		886,000
Issuance of common shares from the release of restricted stock units	(906)	9	(915)
Issuance of common shares pursuant to underwritten public offerings (in shares)		81,938,000
Issuance of common shares pursuant to underwritten public offerings	166,864	819	166,045
Conversion of notes payable (in shares)		71,250,000
Conversion of notes payable	184,537	713	183,824
Fair value of forward purchase contracts	1,237		1,237
Issuance of common shares pursuant to litigation settlement (in shares)		225,000
Issuance of common shares pursuant to litigation settlement	438	2	436
Commitment to deliver common shares pursuant to litigation settlement to additional paid-in capital	6,056		6,056
Issuance of common shares under Employee Stock Purchase Plan (in shares)	422,260	211,000
Issuance of common shares under Employee Stock Purchase Plan	862	2	860
Stock-based compensation	13,292		13,292
Unrealized gain/(loss) on foreign currency translation	(2)			(2)
Reclassification adjustment for gains (losses) included in net loss	(48)			(48)
Net loss	(169,366)us-gaap_NetIncomeLoss				(169,366)
Ending Balance at Dec. 31, 2012	(110,679)us-gaap_StockholdersEquity	2,860	1,991,379	(6)	(2,104,912)
Ending Balance (in shares) at Dec. 31, 2012		286,035,000
Exercise of stock options (in shares)		880,000
Exercise of stock options	2,270	9	2,261
Issuance of common shares from the release of restricted stock units (in shares)		1,870,000
Issuance of common shares from the release of restricted stock units	(4,801)	20	(4,821)
Issuance of common shares pursuant to warrant exercises (in shares)		66,353,000
Issuance of common shares pursuant to warrant exercises	172,149	664	171,485
Issuance of common shares pursuant to debt conversions by Deerfield (in Shares)		1,095,000
Issuance of common shares pursuant to debt conversions by Deerfield	5,501	12	5,489
Issuance of common stock (in shares)		9,824,000
Issuance of common stock	48,888	99	48,789
Issuance of common shares pursuant to litigation settlement (in shares)		2,778,000
Issuance of common shares pursuant to litigation settlement		28	(28)
Issuance of common shares under Employee Stock Purchase Plan (in shares)	463,290	557,000
Issuance of common shares under Employee Stock Purchase Plan	1,263	5	1,258
Stock-based compensation	45,186		45,186
Unrealized gain/(loss) on foreign currency translation	2			2
Commitment to deliver common shares pursuant to Deerfield conversion to additional paid-in capital	998		998
Net loss	(191,490)us-gaap_NetIncomeLoss				(191,490)
Ending Balance at Dec. 31, 2013	(30,713)us-gaap_StockholdersEquity	3,697	2,261,996	(4)	(2,296,402)
Ending Balance (in shares) at Dec. 31, 2013		369,392,000
Exercise of stock options (in shares)	3,250,149	3,251,000
Exercise of stock options	10,978	35	10,943
Issuance of common shares from the release of restricted stock units (in shares)		3,996,000
Issuance of common shares from the release of restricted stock units	(26,908)	38	(26,946)
Issuance of common shares pursuant to warrant exercises (in shares)		11,575,000
Issuance of common shares pursuant to warrant exercises	27,779	115	27,664
Issuance of common shares pursuant to debt conversions by Deerfield (in Shares)		17,521,000
Issuance of common shares pursuant to debt conversions by Deerfield	93,501	174	93,327
Issuance of common shares under Employee Stock Purchase Plan (in shares)	305,076	324,000
Issuance of common shares under Employee Stock Purchase Plan	1,363	2	1,361
Remeasurement of performance based grants pursuant to the modification of terms	22,962		22,962
Stock-based compensation	25,660		25,660
Unrealized gain/(loss) on foreign currency translation	(10)			(10)
Net loss	(198,382)us-gaap_NetIncomeLoss				(198,382)
Ending Balance at Dec. 31, 2014	$ (73,770)us-gaap_StockholdersEquity	$ 4,061	$ 2,416,967	$ (14)	$ (2,494,784)
Ending Balance (in shares) at Dec. 31, 2014		406,059,000

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Equity impact of the value of new stock issued during the period. Includes shares issued in an initial public offering or a secondary public offering.

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- Definition

Value of stock related to Restricted Stock Awards issued during the period, net of the stock value of such awards forfeited.

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- Definition

Value of stock issued as a result of the exercise of stock options.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 04

-Article 3

Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 505

-SubTopic 10

-Section 50

-Paragraph 2

-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21463-112644

Reference 3: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 505

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SX 210.3-04)

-URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187085-122770

Reference 4: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 210

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SX 210.5-02.29-31)

-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 5: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 29, 30, 31

-Article 5

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